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Gabbay KH (1975) Hyperglycemia, polyol metabolism and complications of diabetes mellitus. Annu Rev Med 26: 521–550
West KM (1982) Hyperglycaemia as a cause of longterm complications. In: Keen H, Jarrett RJ (eds) Complications of diabetes, 2 edn. Arnold, London, pp 13–18
Fox CJ, Darby SC, Ireland JT, Sönksen PH (1977) Blood glucose control and glomerular capillary basement membrane thickening in experimental diabetes. Br Med J 2: 605–607
Allen DW, Schroeder WA, Balog J (1958) Observations on the Chromatographic heterogeneity of normal adult and fetal hemoglobin. J Am Chem Soc 80: 1628–1634
Holmquist WR, Schroeder WA (1966) A new terminal blocking group involving a Schiff base in hemoglobin A1c. Biochemistry 5: 2489–2503
Bookchin RM, Gallop PM (1968) Structure of hemoglobin A1c; nature of the N-terminal B-chain blocking group. Biochem Biophys Res Commun 32: 86–93
Bunn HF, Haney DN, Kamin S (1976) The biosynthesis of human hemoglobin A1c: slow glycosylation of hemoglobin in vivo. J Clin Invest 57: 1652–1659
Koenig RJ, Peterson CM, Jones RL, Sandek C, Lehrman H, Cerami A (1976) Correlation of glucose regulation and hemoglobin A1c in diabetes mellitus. N Engl J Med 295: 417–420
Gabbay KH, Hasty K, Breslow JL, Ellison RC, Bunn HF, Gallop PM (1977) Glycosylated hemoglobins and long-term blood glucose control in diabetes mellitus. J Clin Endocr Metab 44: 859–864
Tze WJ, Thompson KH, Leichter J (1978) HbA1c —an indicator of diabetic control. J Pediatr 93: 13–16
Gonen B, Rubenstein AH, Rochman H, Tanega SF, Horwitz DL (1977) Haemoglobin A1: an indicator of the metabolic control of diabetic patients. Lancet 2: 734–737
Ditzel J, Kjaergaard J (1978) Haemoglobin A1c concentrations after initial insulin treatment for newly discovered diabetes. Br Med J 1: 741–742
Peterson CM, Jones RL (1977) Minor hemoglobins, diabetic ‘control’ and diseases of post-synthetic protein modification. Annals Int Med 87: 489–491
Bunn HF, Gabbay KH, Gallop PM (1978) The glycosylation of hemoglobin: relevance to diabetes mellitus. Science 200: 21–27
Bunn HF, Shapiro R, McManus M, Garrick L, McDonald MJ, Gallop PM, Gabbay KH (1979) Structural heterogeneity of human hemoglobin due to non-enzymatic glycosylation. J Biol Chem 254: 3892–3898
Garlick RL, Mazer JS, Higgins PJ, Bunn HF (1983) Characterization of glycosylated hemoglobins. J Clin Invest 71: 1062–1072
McDonald MJ, Bleichman M, Bunn HF, Noble RW (1979) Functional properties of the glycosylated minor components of human adult hemoglobin. J Biol Chem 254: 702–707
Samaja M, Melotti D, Carenini A, Pozza G (1982) Glycosylated haemoglobins and the oxygen affinity of whole blood. Diabetologia 23: 399–402
Ditzel J, Standl E (1975) The problem of tissue oxygenation in diabetes mellitus. II: Evidence of disordered oxygen release from the erythrocytes of diabetics in various conditions of metabolic control. Acta Med Scand (Suppl) 578: 49–58
Ditzel J, Andersen H, Peters ND (1975) Oxygen affinity of haemoglobin and red cell 2,3-diphosphoglycerate in childhood diabetes. Acta Paediatr Scand 64: 355–361
Bailey AJ, Robins SP, Tanner MJA (1976) Reducible components in the proteins of human erythrocyte membrane. Biochim Biophys Acta 434: 51–57
Millar JA, Gravellese E, Bunn HF (1980) Non-enzymatic glycosylation of erythrocyte membrane proteins; relevance to diabetes. J Clin Invest 65: 896–901
Schleicher E, Scheller L, Wieland OH (1981) Quantitation of lysine-bound glucose of normal and diabetic erythrocyte membranes by HPLC analysis of furosine. Biochem Biophys Res Commun 99: 1011–1019
McMillan DE, Utterback NG, La Puma J (1978) Reduced erythrocyte deformability in diabetes. Diabetes 27: 895–901
McMillan DE, Utterback NG, Sparks LL, Bramwell PC (1981) Impaired doublet formation in diabetes. Diabetologia 21: 575–578
Baba Y, Motoaki K, Kamada T, Setoyama S, Otsuji S (1979) Higher levels of erythrocyte membrane microviscosity in diabetes. Diabetes 28: 1138–1140
Otsui S, Baba Y, Kamada T (1981) Erythrocyte membrane microviscosity in diabetes. Horm Metab Res (Suppl II): 97–102
McMillan DE (1983) Insulin, diabetes and the cell membrane: an hypothesis. Diabetologia 24: 308–310
Bryszewska M, Leyko W (1983) Effect of insulin on human erythrocyte membrane fluidity in diabetes mellitus. Diabetologia 24: 311–313
McFarland KF, Catalano EW, Day JF, Thorpe SR, Baynes JW (1979) Non-enzymatic glucosylation of serum proteins in diabetes mellitus. Diabetes 28: 1011–1014
Dolhofer R, Renner R, Wieland OH (1981) Different behaviour of haemoglobin A1a-c and glycosyl-albumin levels during recovery from diabetic ketoacidosis and non-acidotic coma. Diabetologia 21: 211–215
Kennedy L, Mehl TD, Riley WJ, Merimee TJ (1981) Non-enzymatically glycosylated serum protein in diabetes mellitus: an index of short-term glycaemia. Diabetologia 21: 94–98
Shaklai N, Garlick RL, Bunn HF (1983) Tryptophan fluorescence and ligand binding properties of glycosylated human serum albumin. Fed Proc 42: 2098 (Abstract)
Mereish KA, Rosenberg H, Cobby J (1982) Glycosylated albumin and its influence on salicylate binding. J Pharm Sci 71: 235–238
Williams SK, Devenny JJ, Bitensky MW (1981) Micropinocytotic ingestion of glycosylated albumin by isolated microvessels: possible role in pathogenesis of diabetic microangiopathy. Proc Natl Acad Sci USA 78: 2393–2397
Murtiashaw MH, Baynes JW, Thorpe SR (1983) Albumin catabolism in diabetic rats. Arch Biochem Biophys (in press)
Day JF, Thornburg RW, Thorpe SR, Baynes JW (1979) Non-enzymatic glucosylation of rat albumin. J Biol Chem 254: 9394–9400
Poffenbarger Pl, Megna AT (1979) Effect of glycosylation on function and metabolism of serum albumin. In: Srivastava SK (ed) Red blood cell and lens metabolism. Elsevier-North Holland, New York, pp 485–488
McVerry BA, Hopp A, Fisher G, Huehns ER (1980) Production of pseudodiabetic renal glomerular changes in mice after repeated injections of glycosylated proteins. Lancet 1: 738–740
Michael AF, Brown DM (1981) Increased concentration of albumin in kidney basement membranes in diabetes mellitus. Diabetes 30: 843–846
Chavers B, Etzwiler D, Michael AF (1981) Albumin deposition in dermal capillary basement membrane in insulin-dependent diabetes mellitus. Diabetes 30: 275–278
Jeraj KP, Michael AF, Mauer M, Brown DM (1983) Glycosylated and normal human and rat albumin do not bind to renal basement membranes of diabetic and control rats. Diabetes 32: 380–382
Gonen B, Baenziger J, Schonfeld G, Jacobson D, Farrar P (1981) Non-enzymatic glycosylation of low density lipoproteins in vitro. Diabetes 30: 875–878
Witztum JL, Mahoney EM, Branks MJ, Fisher M, Elam R, Stein berg D (1982) Non-enzymatic glycosylation of low-density lipoprotein alters its biologic activity. Diabetes 31: 283–291
Schleicher E, Deufel T, Wieland OH (1981) Non-enzymatic glycosylation of human serum lipoproteins. Elevated ɛ-lysine glycosylated low density lipoproteins in diabetic patients. FEBS Lett 129: 1–4
Kraemer FB, Chen Y-DI, Cheung RMC, Reaven CM (1982) Are the binding and degradation of low density lipoprotein altered in Type 2 (non-insulin-dependent) diabetes mellitus? Diabetologia 23: 28–33
Witztum JL, Fisher M, Pietro T, Steinbrecher UP, Elam RL (1982) Non-enzymatic glycosylation of high-density lipoprotein accelerates its catabolism in guinea pigs. Diabetes 31: 1029–1032
Vlassara H, Brownlee M, Cerami A (1981) Non-enzymatic glycosylation of peripheral nerve protein in diabetes mellitus. Proc Natl Acad Sci USA 78: 5190–5192
Vlassara H, Brownlee M, Cerami A (1983) Excessive non-enzymatic glycosylation of peripheral and central nervous system myelin components in diabetics rats. Diabetes 32: 670–674
Tellez-Nagel I, Korthals JK, Vlassara H, Cerami A (1977) An ultrastructural study of chronic sodium cyanate induced neuropathy. J Neuropath Exp Neurol 43: 351–363
Williams SK, Howarth NL, Devenny JJ, Bitensky MW (1982) Structural and functional consequences of increased tubulin glucosylation in diabetes mellitus. Proc Natl Acad Sci USA 79: 6546–6550
Stevens VJ, Rouzer CA, Monnier VM, Cerami A (1978) Diabetic cataract formation: role of glycosylation of lens crystallins. Proc Natl Acad Sci USA 75: 2918–2922
Monnier VM, Stevens VJ, Cerami A (1979) Non-enzymatic glycosylation, sulfhydryl oxidation, and aggregation of lens proteins in experimental sugar cataracts. J Exp Med 150: 1098–1107
Kasai K, Nakamura T, Kase N, Hiraoka T, Suzuki R, Kogure F, Shimoda S-I (1983) Increased glycosylation of proteins from cataractous lenses in diabetes. Diabetologia 25: 36–38
Ansari NHM, Awasthi YL, Srivastava SK (1980) Role of glycosylation in protein disulphide formation and cataractogenesis. Exp Eye Res 31: 9–19
Chiou SH, Chylack LT, Bunn HF, Kinoshita JH (1980) Role of non-enzymatic glycosylation in experimental cataract formation. Biochem Biophys Res Commun 95: 894–901
Kennedy L, Mehl TD, Elder E, Varghese M, Merinee TJ (1982) Non-enzymatic glycosylation of serum and plasma proteins, Diabetes 31 (Suppl 3): 52–56
Cotlier E, Sharma YR, Niven T, Brescia M (1983) Distribution of salicylate in lens and intraocular fluids and its effect on cataract formation. Am J Med 83–90
Schnider SL, Kohn RR (1980) Glycosylation of human collagen in aging and diabetes mellitus. J Clin Invest 66: 1179–1181
Schnider SL, Kohn RR (1981) Effects of age and diabetes mellitus on the solubility and non-enzymatic glycosylation of human skin collagen. J Clin Invest 67: 1630–1635
Rosenberg H, Modrak JB, Hassing JM, Al-Turk WA, Stohs SJ (1979) Glycosylated collagen. Biochem Biophys Res Commun 91: 498–501
Cohen MP, Urdanivia E, Surma M, Wu VY (1980) Increased glycosylation of glomerular basement membrane collagen in diabetes. Biochem Biophys Res Commun 95: 765–769
Yue DK, McLennan S, Delbridge L, Handelsman DJ, Reeve T, Turtle JR (1983) The thermal stability of collagen in diabetic rats: correlation with severity of diabetes and non-enzymatic glycosylation. Diabetologia 24: 282–285
Lubec G, Pollack A (1980) Reduced susceptibility of non-enzymatically glycosylated glomerular basement membrane to proteases. Renal Physiol 3: 4–8
Rosenbloom AL, Silverstein JH, Lezotte DC, Richardson K, McCallum M (1981) Limited joint mobility in childhood diabetes mellitus indicates increased risk for microvascular disease. N Engl J Med 305: 191–194
Kennedy L, Beacom R, Archer DB, Carson DJ, Campbell SL, Johnston PB, Maguire CJ (1982) Limited joint mobility in Type I diabetes mellitus. Postgrad Med J 58: 481–484
Buckingham BA, Uitto J, Sandberg C, Keens T, Kaufman F, Landing B (1981) Scleroderma-like syndrome and the non-enzymatic glycosylation of collagen in children with poorly controlled insulin dependent diabetes. Paediatr Res 15 (part1): 626 (Abstract)
Madia AM, Rozavski SJ, Kagan HM (1979) Changes in lung lysyl oxidase activity in streptozotocin-diabetes and in starvation. Biochim Biophys Acta 585: 481–487
Chang K, Uitto J, Rowold EA, Grant GA, Kilo C, Williamson JR (1980) Increased collagen crosslinkages in experimental diabetes. Diabetes 29: 778–781
Monnier VM, Kohn RR, Cerami A (1982) Accelerated browning of collagen in diabetic humans. Diabetes 31 (Suppl 2) 28 A
Eble AS, Thorpe SR, Baynes JW (1983) Non-enzymatic glucosylation and glucose-dependent cross-linking of protein. J Biol Chem 258: 9406–9412
Thorpe SR, Baynes JW (1982) Non-enzymatic glycosylation of proteins in vitro and in vivo. In: Horowitz MI, Pigman W (eds) The glycoconjugates, Vol 3. Academic Press, New York, pp 113–131
Schleicher E, Wieland OH (1981) Specific quantitation by HPLC of protein (lysine) bound glucose in human serum albumin and other glycosylated proteins. J Clin Chem Clin Biochem 19: 81–87
Fluckiger R, Winterhalter KH (1976) In vitro synthesis of haemoglobin A1c FEBS Lett 71: 356–360
Pecoraro RE, Graf RJ, Halter JB, Beiter H, Porte D Jr (1979) Comparison of a colorimetric assay for glycosylated hemoglobin with ion-exchange chromatography. Diabetes 28: 1120–1125
Kennedy L, Mehl TD, Merimee TJ (1979) Non-enzymatically glycosylated serum protein: spurious elevation due to free glucose in serum. Diabetes 29: 413–415
Gallop PM, Fluckiger R, Hannekin A, Mininsohn MM, Gabbay KH (1981) Chemical quantitation of hemoglobin glycosylation: fluorimetric detection of formaldehyde released upon periodate oxidation of glycoglobin. Analyt Biochem 117: 427–432
Unger RH (1981) The milieu interieur and the islets of Langerhans. Diabetologia 20: 1–11
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Kennedy, L., Baynes, J.W. Non-enzymatic glycosylation and the chronic complications of diabetes: an overview. Diabetologia 26, 93–98 (1984). https://doi.org/10.1007/BF00281113
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DOI: https://doi.org/10.1007/BF00281113