Summary
The quantitative differences between the activity of the 3 common phenotypes of human red cell GPT has been confirmed. In addition, the activity of red cell GPT 1 was found to be greater in young children than in adults. No such difference was found for the GPT 2 phenotype. The activity of the red cell GPT 1 was found to decreased with age, reaching the adult level at the age of 10 to 12 years. Red cell GPT of all the 3 common phenotypes in both adults and children was found to show a similar response to the addition of excess pyridoxal phosphate.
A method has been devised for the partial purification of human GPT (cytoplasmic) from liver. GPT 1 and GPT 2 have been purified, and very few significant differences were found amongst the physical and kinetic parameters tested.
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Welch, S. Comparative studies on the human glutamate-pyruvate transaminase phenotypes — GPT 1, GPT 2-1, GPT 2. Humangenetik 30, 237–249 (1975). https://doi.org/10.1007/BF00279189
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DOI: https://doi.org/10.1007/BF00279189