Summary
A family with a distinct form of congenital generalized hypertrichosis was studied. Males were more severely affected than females, who exhibited asymmetric hair distribution. This finding was attributed to lyonization, since genealogical studies indicated an X-linked pattern of inheritance. A back mutation is postulated as the origin of this new phenotype.
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Beighton P (1970) Congenital hypertrichosis lanuginosa. Arch Dermatol 101:669–672
Byars LT, Sarnat BG (1944) Congenital macrogingivae (fibromatosis gingivae) and hypertrichosis. Surgery 15:964–970
Cantú JM, García-Cruz D, Sánchez-Corona J, Hernández A, Nazará Z (1982) A distinct osteochondrodysplasia with hypertrichosis. Individualization of a probable autosomal recessive entity. Hum Genet 60:36–41
Danforth CH (1925) Studies on hair with special reference to hypertrichosis. Arch Dermatol Syphilol 12:380–401
Felgenhauer WR (1969) Hypertrichosis lanuginosa universalis. J Genet Hum 17:1–44
Freire-Maia N, Felizali H, de Figuereido AC, Opitz JM, Parreira M, Maia NA (1976) Hypertrichosis lanuginosa in a mother and son. Clin Genet 10:303–306
Leakey RE, Lewin R (1977) Origins. What new discoveries reveal about the emergenece of our species and its possible future. EP Dutton, New York, p 137
McKusick VA (1983) Mendelian inheritance in man, 6th ed. Johns Hopkins University Press, Baltimore
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Macías-Flores, M.A., García-Cruz, D., Rivera, H. et al. A new form of hypertrichosis inherited as an X-linked dominant trait. Hum Genet 66, 66–70 (1984). https://doi.org/10.1007/BF00275189
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DOI: https://doi.org/10.1007/BF00275189