Summary
A controlled prospective randomised trial of 295 arthroplasties of the hip and knee joints was carried out to compare the effect of systemic Cefuroxime with Cefuroxime in bone cement in the prevention of early infection. There was no statistical difference in the incidence of early superficial or deep infection between the two groups. Both methods of administering Cefuroxime appear to be satisfactory in the prevention of early infection after total joint replacement.
Résumé
Les auteurs ont réalisé un essai thérapeutique prospectif randomisé sur 295 arthroplasties de la hanche et du genou, afin de comparer les effets du céfuroxime administré par voie générale à ceux du même antibiotique mêlé au ciment, dans la prévention de l'infection post-opératoire précoce. Il n'a pas été mis en évidence, entre les deux groupes, de différence stastistique de la fréquence des infections précoces, superficielles et profondes. Les deux modes d'administration du céfuroxime semblent assurer une prévention satisfaisante de l'infection précoce dans les arthroplasties totales.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Buchholz HW, Elson RA, Heinert K (1984) Antibiotic-loaded acrylic cement: Current concepts. Clin Orthop 190: 96–108
Buchholz HW, Englebrecht H (1970) Uber di Depotwirkung einiger Antibiotica bei Vermischung mit dem Kunstharz Palacos. Chirurg 41: 511–515
Court-Brown CM, Hughes SPF (1983) The Role of cefuroxime in Total Joint Replacement. Res Clin Forums 5: 27–34
Coventry MB, Beckenbaugh RD,Nolan DR, Ilstrup DM (1974) 2012 Total hip arthroplasties: A study of the postoperative course and early complications. J Bone Joint Surg 56 [A]: 273–284
Ericson C, Lidgren L, Lindberg L (1973) Cloxacillin in the prophylaxis of post-operative infections of the hip. J Bone Joint Surg 55 [A]: 808–813
Fitzgerald RH, Nolan DR, Ilstrup DM, Van Scoy RE, Washington JA, Coventry MB (1977) Deep wound sepsis following total hip arthroplasty. J Bone Joint Surg 59 [A]: 847–855
Hill C, Flamant R, Mazas F, Evrard J (1981) Prophylactic cefazolin versus placebo in total hip replacement: Report of a multicentre double-blind randomised trial. Lancet 1: 795–797
Hughes SPF, Field CA, Kennedy MKR, Dash CH (1979) Cephalosporins in Bone Cement. J Bone Joint Surg 61 [B]: 96–100
Hughes SPF, Robertson S, Want S, Darrell JH, Kennedy MKR, Dash CH (1980) Cefuroxime in bone. In Wood C, Rue Y. (eds) The Royal Society of Medicine, International Congress and Symposium Series No. 38: 163–171
Hughes SPF, Want S, Darrell JH, Dash CH, Kennedy (1982) Prophylactic cefuroxime in total joint replacement. Int Orthop 6: 155–161
Josefsson G, Lindberg L, Wilander B (1981) Systemic antibiotics and gentamycin containing bone cement in the prophylaxis of post-operative infections in total hip arthroplasty. Clin Orthop 159: 194–200
Lidwell OM, Lowbury EJL, Whyte W, Blowers R, Stanley SJ, Lowe D (1984) Infection and sepsis after operations for total hip or knee joint replacement: Influence of ultraclean air, prophylactic antibiotics and other factors. J Hyg 93: 505–529
Pollard JP, Hughes SPF, Scott JE, Evans MJ, Benson MKD (1970) Antibiotic prophylaxis in total hip replacement. Br Med J 1: 707–709
Schurman DJ, Hirschman HP, Burton DS (1980) Cephalothin and Cefamandole penetration into bone, synovial fluid and wound drainage fluid. J Bone Joint Surg 62 [A]: 981–985
Williams DN, Gustilo RB, Beverly R, Kind AC (1983) Bone and serum concentrations of five cephalosporin drugs: Relevance to prophylaxis and treatment in orthopaedic surgery. Clin Orthop 179: 253–265
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
McQueen, M., Littlejohn, A. & Hughes, S.P.F. A comparison of systemic Cefuroxime and Cefuroxime loaded bone cement in the prevention of early infection after total joint replacement. International Orthopaedics 11, 241–243 (1987). https://doi.org/10.1007/BF00271455
Issue Date:
DOI: https://doi.org/10.1007/BF00271455