Summary
Serum concentrations of immunoglobulin G (IgG), immunoglobulin M (IgM) and immunoglobulin A (IgA) were determined in 15 women with a lack of X chromosome material (Turner's syndrome), and compared with the immunoglobulin concentrations in normal men and women. Further, the investigation is supplemented by a comparison of normal women and the Turner group matched according to age.
The serum concentrations of IgG and IgA in women with Turner's syndrome were very close to the concentration in serum from normal men, whereas the concentration of IgM was significantly lower. Compared to normal women the concentrations of IgG and IgM were significantly lower, and the concentration of IgA significantly higher in the Turner group.
Whether these differences in serum immunoglobulins are determined by hormonal factors or under direct genetic control linked to the X chromosomes, is discussed.
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Bachmann, R.: Studies on the serum gamma A globulin level. III. The frequency of A —gamma A — globulinemia. Scand. J. clin. Lab. Invest. 17, 316 (1965)
Bliss, C. I.: Statistics in biology, chap. 9: New York-St. Louis-San Francisco-Toronto-London-Sydney: McGraw-Hill 1967
Buckley, C. E., Dorsey, F. C.: Serum immunoglobulin levels throughout the life-span of healthy man. Ann. intern. Med. 75, 673 (1971)
Butterworth, M., McClellan, B., Allansmith, M.: Influence of sex on immunoglobulin levels. Nature (Lond.) 214, 1224 (1967)
Kalff, M. W.: A population study on serum immunoglobulin levels. Clin. chim. Acta 28, 277 (1970)
Laurell, C.-B.: Quantitative estimation on proteins by electrophoresis in agarose gel containing antibodies. Analyt. Biochem. 15, 45 (1966)
Laurell, C.-B., Kullander, S., Thorell, J.: Effect of administration of a combined estrogenprogestin contraceptive on the level of individual plasma proteins. Scand. J. clin. Lab. Invest. 21, 337 (1967)
Laurell, C.-B., Kullander, S., Thorell, J.: Plasma proteins after continuous oral use of progestogen-chloromadionone acetate — as a contraceptive. Scand. J. clin. Lab. Invest. 24, 387 (1969)
Lyngbye, J., Krøll, J.: Quantitative immunoelectrophoresis of proteins in serum from a normal population: season, age, and sex related variations. Clin. Chem. 17, 495 (1971)
Rhodes, K., Markham, R. L., Maxwell, P. M., Monk-Jones, M. E.: Immunoglobulins and the X chromosome. Brit. med. J. 1969 III, 439
Uffelman, J. A., Engelhard, W. E., Jolliff, C. R.: Quantitation of immunoglobulins in normal children. Clin. chim. Acta 28, 185 (1970)
Washburn, T. C., Medearis, D. N., Childs, B.: Sex differences in susceptibility to infections. Pediatrics 35, 57 (1965)
Weeke, B.: Carbamylated human immunoglobulins tested by electrophoresis in agarose and antibody containing agarose. Scand. J. clin. Lab. Invest. 21, 351 (1968a)
Weeke, B.: Quantitative estimation of human immunoglobulins following carbamylation by electrophoresis in antibody containing agarose. Scand. J. clin. Lab. Invest. 22, 107 (1968b)
Weeke, B., Krasilnikoff, P. A.: A polynomial expression for the serum concentrations of 21 serum proteins from 1–93 years of age in normal females and males. Proteides of the biological fluids (ed. H. Peeters), Vol. 18, p. 173. Oxford: Pergamon Press 1971
Weeke, B., Krasilnikoff, P. A.: The concentration of 21 serum proteins in normal children and adults. Acta med. scand. 192, 149 (1972)
Wood, C. B. S., Martin, W., Adinolfi, M., Polani, P. E.: Levels of gamma M and gamma G globulins in women with XO chromosomes. Atti Ass. Genet. Ital. 15, 228 (1970)
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Jensen, K., Petersen, P.H., Nielsen, E.L. et al. Serum immunoglobulin M, G, and A concentration levels in Turner's syndrome compared with normal women and men. Hum Genet 31, 329–334 (1976). https://doi.org/10.1007/BF00270862
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DOI: https://doi.org/10.1007/BF00270862