Abstract
Choroid plexus tumors are rare and account for only 2.3% (8/352) of primary childhood intracranial neoplasms in our series. Most of our patients were under 2 years of age. The tumors had a predilection for the lateral ventricle. Calcification was found in half of these tumors, and ossification was seen in 1 case. Histological features of malignancy including invasion, loss of differentiation, and severe nuclear pleomorphism pointed to a poor prognosis. Such features were found in 2 cases. Neither a large number of mitoses nor necrosis was a constant feature in cases of malignancy. Transthyretin, a marker for choroid plexus tumors, was positive in all cases. However, negative S-100 or positive carcinoembryonic antigen was not necessarily associated with a more aggressive histological pattern. All the papillomas could be totally resected without recurrence, and all the patients with carcinoma died within a few months.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Aleshire SL, Bradley CA, Richardson LD, Parl FF (1983) Localization of human prealbumin in choroid plexus epithelium. J Histochem Cytochem 31:608–612
Cardozo J, Cepeda F, Quintero M, Mora E (1985) Choroid plexus papilloma containing bone. Acta Neuropathol (Berl) 68:83–85
Chan RC, Thompson GB, Durity FA (1983) Primary choroid plexus papilloma of the cerebellopontine angle. Neurosurgery 12:334–336
Coffin CM, Wick MR, Braun JT, Dehner LP (1986) Choroid plexus neoplasms. Clinicopathologic and immunohistochemical studies. Am J Surg Pathol 10:394–404
Dohrmann GJ, Collias JC (1975) Choroid plexus carcinoma (Case report). J Neurosurg 43:225–232
Ellenbogen RG, Winston KR, Kupsky WJ (1989) Tumors of the choroid plexus in children. Neurosurgery 25:327–335
Felix I, Phudhichareonrat S, Halliday WC, Becker LE (1987) Choroid plexus tumors in children: immunohistochemical and seanning-electron-microscopic features. Pediatr Neurosci 13:263–269
Gradin WC, Taylon C, Fruin AH (1983) Choroid plexus papilloma of the third ventricle: case report and review of the literature. Neurosurgery 12:217–220
Hawkins JC III (1980) Treatment of choroid plexus papillomas in children: a brief analysis of twenty years' experience. Neurosurgery 6:380–384
Herbert J, Wilcox JN, Pham KTC, Fremeau RT, Zeriani M, Dwork A, Soprano DR, Makover A, Goodman DS, Zimmerman EA, Roberts JL, Schon EA (1986) Transthyretin: a choroid plexus-specific transport protein in human brain. Neurology 36:900–911
Herbert J, Cavallaro T, Dwork AJ (1990) A marker for primary choroid plexus neoplasms. Am J Pathol 136:1317–1325
Lewis P (1967) Carcinoma of the choroid plexus. Brain 90:177–186
Matsushima T, Inoue T, Takeshita I, Fukui M, Iwaki T, Kitamoto T (1988) Choroid plexus papillomas: an immunohistochemical study with particular reference to the coexpression of prealbumin. Neurosurgery 23:384–389
McGirr SJ, Ebersold MJ, Scheithauer BW, Quast LM, Shaw EG (1988) Choroid plexus papillomas: long-term follow-up results in a surgically treated series. J Neurosurg 69:843–849
Nakashima N, Goto K, Takeuchi J (1982) Papillary carcinoma of choroid plexus. Light and electron microscopic study. Virchows Arch [A] 395:303–318
Paulus W, Jänisch W (1990) Clinicopathologic correlations in epithelial choroid plexus neoplasms: a study of 52 cases. Acta Neuropathol (Berl) 80:635–641
Rubinstein LJ, Brucher JM (1981) Focal ependymal differentiation in choroid plexus papillomas. An immunoperoxidase study. Acta Neuropathol (Berl) 53:29–33
Russell DS, Rubinstein LJ (1989) Pathology of tumours of the nervous system, 5th edn. Williams & Wilkins, Baltimore
Spallone A, Pastore FS, Giuffre R, Guidetti B (1990) Choroid plexus papillomas in infancy and childhood. Child's Nerv Syst 6:71–74
Tomasello F, Albanese V, Bernini FP, Picozzi P (1981) Choroid plexus papilloma of the third ventricle. Surg Neurol 16:69–71
Van Swieten JC, Thomeer RT, Vielvoye GJ, Bots GT (1987) Choroid plexus papilloma in the posterior fossa. Surg Neurol 28: 129–134
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ho, D.M., Wong, TT. & Liu, HC. Choroid plexus tumors in childhood. Child's Nerv Syst 7, 437–441 (1991). https://doi.org/10.1007/BF00263185
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00263185