Summary
Ten previously untreated patients with metastatic non-seminomatous testicular carcinoma received cis-diamminechloroplatinum (CDDP). Renal function studies were performed before and following the first CDDP infusion. A decrease in effective renal plasma flow (ERPF) and an increase in filtration fraction (FF) was found in all patients. These findings suggest primary changes in renal hemodynamics during CDDP infusion.
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Offerman, J.J.G., Meijer, S., Sleijfer, D.T. et al. Acute effects of cis-diamminedichloroplatinum (CDDP) on renal function. Cancer Chemother. Pharmacol. 12, 36–38 (1984). https://doi.org/10.1007/BF00255906
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DOI: https://doi.org/10.1007/BF00255906