Summary
Aclacinomycin, which is more lipophilic than daunorubicin and doxorubicin, is taken up and released more rapidly and extensively by L1210 cells. After 5 h of incubation 91% of aclacinomycin is found in the nuclei of L1210 cells and the drug present in the post-nuclear fraction is distributed between the lysosomes and the cytosol. After an incubation of 5 h aclacinomycin decreases the density of the lysosomes. This effect is not observed either with doxorubicin or daunorubicin or when the cells are incubated with aclacinomycin for only 30 min.
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Zenebergh, A., Baurain, R. & Trouet, A. Cellular pharmacokinetics of aclacinomycin A in cultured L1210 cells. Cancer Chemother. Pharmacol. 8, 243–249 (1982). https://doi.org/10.1007/BF00255491
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DOI: https://doi.org/10.1007/BF00255491