Summary
The effect of cyclopropene fatty acids, sterculic and malvalic, on the lipids of yeasts grown under nitrogen limiting, lipid accumulating, conditions was studied. The ratio of stearic to oleic acid showed a dose response effect, with an increase in stearic acid content as the dose of cyclopropene fatty acid increased, and a corresponding reduction in oleic acid. Linoleic and linolenic acids were not affected to the same extent. These effects are shown for the yeasts Candida sp. 107, Trichosporon cutaneum, and Rhodosporidium toruloides.
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References
Christie WW (1970) Cyclopropane and cyclopropene fatty acids. In: Topics in lipid chemistry, vol I. Edited by FD Gunstone. Logos Press, London
Ferrante G, Ohno Y, Kates M (1983) Influence of temperature and growth phase on desaturase activity of the mesophilic yeast Candida lipolytica. Can J Biochem Cell Biol 61:171–177
James AT, Harris P, Bezard J (1968) The inhibition of unsaturated fatty acid biosynthesis in plants by sterculic acid. Eur J Biochem 3:318–325
Johnson AR, Pearson JA, Shenstone FS, Fogerty AC (1967) Inhibition of the desaturation of stearic to oleic acid by cyclopropene fatty acids. Nature 214:1244–1245
McKeon TA, Stumpf PK (1982) Purification and characterisation of the stearoyl-acyl carrier protein desaturase and the Acyl-acyl carrier protein thioesterase from maturing seeds of safflower. J Biol Chem 257:12 141–12 147
Ratledge C (1982) Microbial oils and fats. An assessment of their commercial potential. Prog Ind Microbiol 16:119–206
Raju PK, Reiser R (1967) Inhibition of fatty acyl desaturase by cyclopropene fatty acids. J Biol Chem 242:379–384
Reiser R, Parekh CK, Meinke WW (1963) The metabolism of cyclopropene fatty acids. In: Frazer AC (ed) Biological problems of lipids, vol I. Elsevier, New York
Schneider EL, Loke SP, Hopkins DT (1968) Gas-liquid chromatographic analysis of cyclopropenoid fatty acids. J Am Oil Chem Soc 45:585–590
Shenstone FS, Vickery JR, Johnson AR (1965) Studies on the chemistry and biological effects of cyclopropenoid compounds. J Agric Food Chem 13:410–414
Yano I, Nicholls BW, Morris LJ, James AT (1972) The distribution of cyclopropane and cyclopropene fatty acids in higher plants (Malvaceae) Lipids 7:30–34
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Moreton, R.S. Modification of fatty acid composition of lipid accumulating yeasts with cyclopropene fatty acid desaturase inhibitors. Appl Microbiol Biotechnol 22, 42–45 (1985). https://doi.org/10.1007/BF00252154
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DOI: https://doi.org/10.1007/BF00252154