Summary
Recent work has shown that humans and monkeys utilize both retinal error and eye position signals to compute the direction and amplitude of saccadic eye movements (Hallett and Lightstone 1976a, b; Mays and Sparks 1980b). The aim of this study was to examine the role the frontal eye fields (FEF) and the superior colliculi (SC) play in this computation. Rhesus monkeys were trained to acquire small, briefly flashed spots of light with saccadic eye movements. During the latency period between target extinction and saccade initiation, their eyes were displaced, in total darkness, by electrical stimulation of either the FEF, the SC or the abducens nucleus area. Under such conditions animals compensated for the electrically induced ocular displacement and correctly reached the visual target area, suggesting that both a retinal error and eye position error signal were computed. The amplitude and direction of the electrically induced saccades depended not only on the site stimulated but also on the amplitude and direction of the eye movement initiated by the animal to acquire the target. When the eye movements initiated by the animal coincided with the saccades initiated by electrical stimulation, the resultant saccade was the weighted average of the two, where one weighting factor was the intensity of the electrical stimulus. Animals did not acquire targets correctly when their eyes were displaced, prior to their intended eye movements, by stimulating in the abducens nucleus area. After bilateral ablation of either the FEF or the SC monkeys were still able to acquire visual targets when their eyes were displaced, prior to saccade initiation, by electrical stimulation of the remaining intact structure. These results suggest that neither the FEF nor the SC is uniquely responsible for the combined computation of the retinal error and the eye position error signals.
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References
Evarts EV (1966) Methods for recording individual neurons in moving animals. In: Rushman RF (ed) Methods in medical research. Year Book Med. Publ., Chicago, pp 241–250
Gisbergen JAM van, Robinson DA, Gielen S (1981) A quantitative analysis of generation of saccadic eye movements by burst neurons. J Neurophysiol 45: 417–442
Hallett PE, Lightstone AD (1976a) Saccadic eye movements toward stimuli triggered by prior saccades. Vision Res 16: 99–106
Hallett PE, Lightstone AD (1976b) Saccadic eye movements to flashed targets. Vision Res 16: 107–114
Mays LE, Sparks LD (1980a) Dissociation of visual and saccaderelated responses in superior colliculus neurons. J Neurophysiol 43: 207–232
Mays LE, Sparks LD (1980b) Saccades are spatially, not retinocentrically coded. Science 208: 1163–1165
Merker B (1979) Protocol for silver staining Nissl substance. M.I.T. Psychology Dept. Res. Paper
Robinson DA (1963) A method of measuring eye movement using a scleral search coil in a magnetic field. IEEE Trans Biomed Eng 10: 137–145
Robinson DA (1970) Oculomotor unit behavior in the monkey. J Neurophysiol 33: 393–404
Robinson DA (1972) Eye movements evoked by collicular stimulation in the alert rhesus monkey. Vision Res 12: 1795–1808
Robinson DA, Fuchs AF (1969) Eye movements evoked by stimulation of frontal eye fields. J Neurophysiol 32: 637–648
Schiller PH (1970) The discharge characteristics of single units in the oculomotor and abducens nuclei of the unanesthetized monkey. Exp Brain Res 10: 347–362
Schiller PH, Koerner F (1972) Discharge characteristics of single units in the superior colliculus of the alert rhesus monkey. J Neurophysiol 34: 920–936
Schiller PH, Stryker M (1972) Single unit recording and stimulation in the superior colliculus of the alert rhesus monkey. J Neurophysiol 35: 915–924
Schiller PH, True SD, Conway JL (1980) Deficits in eye movements following frontal eye-field and superior colliculus ablations. J Neurophysiol 44: 1175–1189
Sparks DL, Porter JD (1981) Utilization of an eye position signal by saccade-related burst neurons in the monkey superior colliculus. Neurosci Abstr 7: 132
Wurtz RH, Goldberg ME (1972) Activity of superior colliculus in behaving monkey. IV. Effects of lesions on eye movement. J Neurophysiol 35: 587–596
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Supported by Grants NIH EY02621 and NIH EY00676-10
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Schiller, P.H., Sandell, J.H. Interactions between visually and electrically elicited saccades before and after superior colliculus and frontal eye field ablations in the rhesus monkey. Exp Brain Res 49, 381–392 (1983). https://doi.org/10.1007/BF00238780
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DOI: https://doi.org/10.1007/BF00238780