Summary
Previous unpublished experiments from this laboratory had revealed only post-activation depression effects in the cerebellar cortex when its inputs were activated by high frequency trains. In the experiments reported in this paper, we found reliable long-term potentiation (LTP) effects in the deep nuclei (interpositus and vestibular) when stimulation trains were applied to the white matter at the point where inferior peduncle fibers enter the cerebellum. LTP effects were found in both acute and chronic preparations. In the chronic preparations, LTP lasted for at least 8 days in all but one animal.
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Albus JS (1971) A theory of cerebellar function. Math Biosci 10: 25–61
Alger BE, Teyler TJ (1976) Long-term and short-term plasticity in the CA1, CA3 and dentate region of the rat hippocampal slice. Brain Res 110: 463–480
Andersen P, Sundberg SH, Sveen O, Wigstrom H (1977) Specific long-lasting potentiation of synaptic transmission in hippocampal slices. Nature 26: 736–737
Bliss TVP, Lomo T (1973) Long-lasting potentiation of synaptic transmission in the dentate area of the anesthetized rabbit following stimulation of the perforant path. J Physiol 232: 331–356
Clark GA, McCormick DA, Lavond DG, Thompson RF (1984) Effects of lesions of cerebellar nuclei on conditioned behavioral and hippocampal neuronal responses. Brain Res 291: 125–136
Davies P, Melville-Jones G (1976) An adaptive neural model compatible with plastic changes induced in the human vestibulo-ocular reflex by prolonged optical reversal of vision. Brain Res 103: 546–550
Dolphin AC, Errington ML, Bliss TVP (1982) Sustained increase in glutamate release associated with long-term potentiation of perforant path in vivo. Nature 29: 496
Douglas RM, Goddard GV (1975) Long-term potentiation of the perforant path-granule cell synapse in the hippocampus. Brain Res 86: 205–215
Galiana HL, Flohr H, Melville-Jones G (1984) A reevaluation of intervestibular nuclear coupling: its role in vestibular compensation. J Neurophysiol 51: 242–259
Galiana HL, Outerbridge JS (1984) A bilateral model for central neural pathways in vestibulo-ocular reflex. J Neurophysiol 51: 210–241
Glickstein M, Hardiman MJ, Yeo CH (1983) The effects of cerebellar lesions on the conditioned nictitating membrane response of the rabbit. J Physiol 341: 30 p
Ito M (1982) Cerebellar control of the vestibulo-ocular reflex — around the flocculus hypothesis. Ann Rev Neurosci 5: 275–296
Lincoln JS, McCormick DA, Thompson RF (1982) Ipsilateral cerebellar lesions prevent learning of the classically conditioned nictitating membrane/eyelid response. Brain Res 242: 190–193
Lynch GS, Dunwiddie T, Gribkoff V (1977) Heterosynaptic depression: a postsynaptic correlate of long-term potentiation. Nature 266: 736–737
Marr D (1969) A theory of cerebellar cortex. J Physiol 202: 437–470
McCormick DA, Clark GA, Lavond DG, Thompson RF (1982) Initial localization of the memory trace for a basic form of learning. Proc Natl Acad Sci USA 79: 2731–2735
McCormick DA, Guyer PE, Thompson RF (1984) Superior cerebellar peduncle lesions selectively abolish the ipsilateral classically conditioned nictitating membrane/eyelid response. Science 223: 296–299
Miles FA, Eighmy BB (1980) Long-term adaptive changes in primate vestibulo-ocular reflex. I. Behavioral observations. J Neurophysiol 43: 1406–1425
Miles FA, Braitman DJ (1980) Long-term adaptive changes in primate vestibulo-ocular reflex. II. Electrophysiological observations on semicircular canal primary afferents. J Neurophysiol 43: 1426–1436
Miles FA, Lisberger SG (1982) Plasticity in the vestibulo-ocular reflex: a new hypothesis. Ann Rev Neurosci 4: 273–299
Paxinos G, Watson C (1982) The rat brain in stereotaxic coordinates. Academic Press, New York
Racine RJ, Milgram NW, Hafner S (1983) Long-term potentiation phenomena in the rat limbic forebrain. Brain Res 260: 217–231
Sastry B (1982) Presynaptic change associated with long-term potentiation in hippocampus. Life Sci 30: 2003–2008
Schwartzkroin PA, Wester K (1975) Long-lasting facilitation of a synaptic potential following tetanization in the in vitro hippocampal slice. Brain Res 89: 107–119
Teyler TJ, Discenna P (1984) Long-term potentiation as a candidate mnemonic device. Brain Res Rev 7: 15–28
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Racine, R.J., Wilson, D.A., Gingell, R. et al. Long-term potentiation in the interpositus and vestibular nuclei in the rat. Exp Brain Res 63, 158–162 (1986). https://doi.org/10.1007/BF00235658
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DOI: https://doi.org/10.1007/BF00235658