Abstract
Rosmarinic acid (RA) is a natural antioxidant produced by cell suspension cultures of sage (Salvia officinalis L.). The growth and production of RA by these cells can be modified by the type of culture medium. Production can be increased 10-fold to attain 6.4 g.1-1 under optimal conditions. Investigation of kinetics showed that a change in the medium caused shifts in peaks of growth and production, and modifications of the cell metabolism. RA production can be correlated with growth or begins only when growth has stopped.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Adzet T, Canigueral S, Iglesias J (1988) Biochem. Syst. & Ecol. 16 (1): 29–32
De-Eknamkul W, Ellis BE (a) (1985) Plant Cell Rep. 4: 46–49
De-Eknamkul W, Ellis BE (b)(1985) Plant Cell Rep. 4: 50–53
De-Eknamkul W, Ellis BE (1984) Planta Med., 51: 346–350
Ellis BE, Tower GHN (1970) Biochem. J. 118: 291–297
Heller R (1953) Ann. Sci. Nat. Bot. Biol. Vég. 14: 1–223
Hippolyte I (1990) PhD thesis, U.S.T.L. Montpellier II, Monpellier. 226 pp.
Ibrahim RK (1987) In: Constabel F. and Vasil I.K. (Eds) Cell culture and somatic cell genetics of plants, Ac. Press. Inc., vol. chap. 3: 77–96
Margna U (1977) Phytochem., 16: 419–426
Merillon JM, Doireau P, Guillot A, Chénieux JC, Rideau M. (1986) Plant Cell Rep. 5: 23–26
Murashige T and Skoog F 1962 Physiol. Plant. 15: 473–497
Nitsch JP, Nitsch C and Hamon S 1968 C.R. Séances Soc. Bio. Paris 162: 369–372
Razzaque A, Ellis B (1977) Planta, 137: 287–291
Su W-W, Humphrey AE (1990) Biotech. Letters. 12: 793–798
Ulbrich B, Wiesner W, Arens H (1985) In: Neumann KH, Barz W, Reinhard E (eds), Primary and secondary metabolism of plant cell cultures, Springer-Verlag, Berlin, pp 293–303
Whitaker RJ, Hashimoto RT, Evans D (1984) Annals New York Acad. Sci. 435: 364–365
Zenk MH, El-Shagi H and Ulbrich B (1977) Natur-wissenschaften 64: 585–586
Author information
Authors and Affiliations
Additional information
Communicated by N. Arnrhein
Rights and permissions
About this article
Cite this article
Hippolyte, I., Marin, B., Baccou, J.C. et al. Growth and rosmarinic acid production in cell suspension cultures of Salvia officinalis L.. Plant Cell Reports 11, 109–112 (1992). https://doi.org/10.1007/BF00232160
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00232160