Abstract
The effects of suprachiasmatic and control lesions on the circadian rhythms of locomotor activity and body temperature were studied in golden hamsters (Mesocricetus auratus) maintained in constant light as well as constant darkness. Large suprachiasmatic lesions, but not control lesions, eliminated circadian rhythmicity in locomotor activity as well as in body temperature. Analysis of the “robustness” of the rhythms of locomotor activity and body temperature in unlesioned and lesioned animals suggests that, because body temperature rhythmicity is more robust than locomotor rhythmicity, lesions that spare a small number of suprachiasmatic cells might abolish the latter but not the former. Our results do not support the hypothesis that the body temperature rhythm is controlled by a circadian pacemaker distinct from the main pacemaker located in the suprachiasmatic nuclei.
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References
Aschoff J (1960) Exogenous and endogenous components in circadian rhythms. Cold Spring Harbor Symp Quant Biol 25: 11–27
Davy J (1845) On the temperature of man. Phil Trans R Soc Lond 135: 319–333
Dowse HB, Ringo JM (1991) Comparisons between “periodograms” and spectral analysis: apples are apples after all. J Theor Biol 148: 139–144
Dunn JD, Castro AJ, McNulty JA (1977) Effect of suprachiasmatic ablation on the daily temperature rhythm. Neurosci Lett 6: 345–348
Eastman C, Rechtschaffen A (1983) Circadian temperature and wake rhythms of rats exposed to prolonged continuous illumination. Physiol Behav 31: 417–427
Eastman C, Mistlberger RE, Rechtschaffen A (1984) Suprachiasmatic nuclei lesions eliminate circadian temperature and sleep rhythms in the rat. Physiol Behav 32: 357–368
Fuller CA, Lydic R, Sulzman FM, Albers HE, Tepper B, MooreEde MC (1981) Circadian rhythm of body temperature persists after suprachiasmatic lesions in the squirrel monkey. Am J Physiol 241: R385-R391
Honma S, Honma K, Shirakawa T, Hiroshige T (1988) Rhythms in behaviors, body temperature and plasma corticosterone in SCN lesioned rats given methamphetamine. Physiol Behav 44: 247–255
Kittrell BMW (1991) The suprachiasmatic nucleus and temperature rhythms. In: Klein DC, Moore RY, Reppert SM (eds) Suprachiasmatic nucleus — the mind's clock. Oxford Univ Press, New York, pp 233–245
Kurumiya S, Kawamura H (1988) Circadian oscillation of the multiple unit activity in the guinea pig suprachiasmatic nucleus. J Comp Physiol A 162: 301–308
Maurel E (1884) Expérience sur les variations nycthémérales de la température normale. C R Soc Biol 37: 588
Pickard GE, Kahn R, Silver R (1984) Splitting of the circadian rhythm of body temperature in the golden hamster. Physiol Behav 32: 763–766
Pittendrigh CS (1981) Circadian systems — entrainment. In: Aschoff J (ed) Handbook of behavioral neurobiology, vol 4. Plenum Press, New York, pp 95–124
Powell EW, Halberg F, Pasley JN, Lubanovic W, Ernsberger P, Scheving LE (1980) Suprachiasmatic nucleus and circadian core temperature rhythm in the rat. J Therm Biol 5: 189–196
Ralph MR, Foster RG, Davis FC, Menaker M (1990) Transplanted suprachiasmatic nucleus determines circadian period. Science 247: 975–978
Refinetti R (1992) Analysis of the circadian rhythm of body temperature. Behav Res Methods Instr Comput 24: 28–36
Refinetti R (1993) Comparison of six methods for the determination of the period of circadian rhythms. Physiol Behav 54: 869–875
Refinetti R, Menaker M (1992) The circadian rhythm of body temperature of normal and tau-mutant golden hamsters. J Therm Biol 17: 129–133
Refinetti R, Nelson DE, Menaker M (1992) Social stimuli fail to act as entraining agents of circadian rhythms in the golden hamster. J Comp Physiol A 170: 181–187
Ruby NF, Ibuka N, Barnes BM, Zucker I (1989) Suprachiasmatic nuclei influence torpor and circadian temperature rhythms in hamsters. Am J Physiol 257: R210-R215
Ruis JF, Rietveld WJ, Buys PJ (1987) Effects of suprachiasmatic nuclei lesions on circadian and ultradian rhythms in body temperature in ocular enucleated rats. J Interdiscipl Cycle Res 18: 259–273
Satinoff E, Presser RA (1988) Suprachiasmatic nuclear lesions eliminate circadian rhythms of drinking and activity but not of body temperature in male rats. J Biol Rhythms 3: 1–22
Sato T, Kawamura H (1984) Effects of bilateral suprachiasmatic nucleus lesions on the circadian rhythms in a diurnal rodent, the Siberian chipmunk (Eutamias sibiricus). J Comp Physiol A 155: 745–752
Sokolove PG, Bushell WN (1978) The chi square periodogram: Its utility for analysis of circadian rhythms. J Theor Biol 72: 131–160
Stephan FK, Nunez AA (1977) Elimination of circadian rhythms in drinking, activity, sleep, and temperature by isolation of the suprachiasmatic nuclei. Behav Biol 20: 1–16
Stephan FK, Zucker I (1972) Circadian rhythms in drinking behavior and locomotor activity of rats are eliminated by hypothalamic lesions. Proc Nat Acad Sci USA 69: 1583–1586
Stetson MH, Watson-Whitmyre M (1976) Nucleus suprachiasmaticus: The biological clock in the hamster? Science 191: 197–199
Summer TL, Ferraro JS, McCormack CE (1984) Phase-response and Aschoff illuminance curves for locomotor activity rhythm of the rat. Am J Physiol 246: R299-R304
Swann JM, Turek FW (1985) Multiple circadian oscillators regulate the timing of behavioral and endocrine rhythms in female golden hamsters. Science 228: 898–900
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Refinetti, R., Kaufman, C.M. & Menaker, M. Complete suprachiasmatic lesions eliminate circadian rhythmicity of body temperature and locomotor activity in golden hamsters. J Comp Physiol A 175, 223–232 (1994). https://doi.org/10.1007/BF00215118
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DOI: https://doi.org/10.1007/BF00215118