Summary
At the sites where a vein penetrates through the dura mater, two aspects deserve particular attention:
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(i)
The delineation of the perivascular cleft, a space belonging to the interstitial cerebrospinal fluid (CSF) compartment, toward the interior hemal milieu of the dura mater.
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(ii)
The relationship between the perivascular arachnoid layer and the subdural neurothelium at the point of vascular penetration. These problems were investigated in the rat and in two species of New-World monkeys (Cebus apella, Callitrix jacchus). Concerning the first aspect, tight appositions of meningeal cells to the vessel wall, the basal lamina of which is widened and enriched with microfibrils, prevent communication between the interstitial CSF in the perivascular cleft and the hemal milieu in the dura mater. With reference to the second aspect, the perivascular arachnoid cells are transformed into neurothelial cells at the point where they become exposed to the hemal milieu of the dura mater and subsequently continuous with the subdural neurothelium. Leptomeningeal protrusions encompassing outer CSF space can penetrate into the dura mater. These protrusions may expand and branch repeatedly, forming along the wall of the durai sinus Pacchionian granulations. At these sites, however, the structural integrity of the sinus wall and the Pacchionian granulation is not lost. Numerous vesiculations not only in the sinus and vascular walls, but also in the cellular arrays of the Pacchionian granulations or paravascular leptomeningeal protrusions indicate mechanisms of transcellular fluid transport. Moreover, the texture of the leptomeningeal protrusions favors an additional function of these structures as a “volume” buffer.
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References
Andres KH (1967a) Über die Feinstruktur der Arachnoidea und Dura mater von Mammalia. Z Zellforsch 79:272–295
Andres KH (1967b) Zur Feinstruktur der Arachnoidalzotten bei Mammalia. Z Zellforsch 82:92–109
Arnold W, Nitze HR, Ritter R, v. Ilberg Ch, Ganzer U (1972) Qualitative Untersuchungen der Verbindungswege des Subarachnoidalraumes mit dem lymphatischen System des Kopfes und des Halses. Acta Otolaryngol 74:411–424
Cooper ERA (1958) Arachnoid granulations in man. Acta Anal 34:187–200
Ebersolt C, Perez M, Vassent G, Bockaert J (1981) Characteristics of the β 1- and β 2-adrenergic-scnsitive adenylate cyclases in glial cell primary cultures and their comparison with β 2-adrenergic-sensitive adenylate cyclase of meningeal cells. Brain Res 213:151–161
Földi M, Gatai G, Papp N, Eöllös Z, Mezaros A (1960) Abtransport von corpusculären Teilchen aus dem Subarachnoidealraum beim Hund. Z Ges Exp Med 133:110–112
Friedman AH, Davis JN (1980) Identification and characterization of adrenergic receptors and catecholamine-stimulated adenylate cyclase in dog pial membranes. Brain Res 183:89–102
Gomcz DG, Ehrmann JE, Potts DG, Pavcse AM, Gilanian A (1983) The arachnoid granulations of the newborn human: An ultrastructural study. Int J Dev Neurosci, Vol 1, pp 139–147
Jayatilaka ADP (1965a) Arachnoid granulations in sheep. J Anat 99:315–327
Jayatilaka ADP (1965b) An electron microscopic study of sheep arachnoid granulations. J Anat 99:635–649
Kaplan GP, Hartmann KB, Creveling CR (1981) Localization of catechol-O-methyltransferase in the leptomeninges, choroid plexus and ciliary epithelium: Implications for the separation of central and peripheral catechols. Brain Res 204:353–360
Krisch B (1986) The functional and structural borders between the CSF- and blood-dominated milieus in the choroid plexuses and the area postrema of the rat. Cell Tissue Res 245:101–115
Krisch B, Buchheim W (1984) Access and distribution of exogenous substances in the intercellular clefts of the rat adenohypophysis. Cell Tissue Res 236:439–452
Krisch B, Leonhardt H (1978) The functional and structural border between the CSF- and blood-milieu in the circumventricular organs (organum vasculosum laminae terminalis, subfornical organ, area postrema) of the rat. Cell Tissue Res 195:485–497
Krisch B, Leonhardt H, Buchheim W (1978) The functional and structural border of the neurohemal region of the median eminence. Cell Tissue Res 192:327–339
Krisch B, Leonhardt H, Oksche A (1983) The meningeal compartments of the median eminence and the cortex. A comparative analysis in the rat. Cell Tissue Res 228:597–640
Krisch B, Leonhardt H, Oksche A (1984) Compartments and perivascular arrangement of the meninges covering the cerebral cortex of the rat. Cell Tissue Res 238:459–474
Levine JE, Povlishock JT, Becker DP (1982) The morphological correlates of primate cerebrospinal fluid absorption. Brain Res 241:31–41
Palmer GC, Palmer SJ (1983) Adenylate cyclase sensitivity to catecholamines and forskolin in rat pia-arachnoid and cerebral microvessels. Neuropharmacology 22:213–221
Sievers H, Sievers J, Baumgarten HG, König N, Schlossberger HG (1983) Distribution of tritium label in the neonate rat brain following intracisternal or subcutaneous administration of 3H-6-OHDA. An autoradiographic study. Brain Res 275:23–45
Stober B (1972) Über Bewegung und Drainage des Liquor cerebrospinalis beim Kaninchen. Untersuchungen mit einer standardisierten Methode. Z Anat Entwickl Gesch 135:307–316
Thomas H (1966) Licht-und elektronenmikroskopische Untersuchungen an den weichen Hirnhäuten und den Pacchionischen Granulationen des Menschen. Z Mikrosk Anat Forsch 75:270–327
Thompson DNP (1984) Arachnoid villi and granulations in the rat and man. New considerations based on light and scanning electron microscopy. J Anat 138:568
Tripathi R (1974) Tracing the bulk outflow route of cerebrospinal fluid by transmission and scanning electron microscopy. Brain Res 80:503–506
Wright PM, Nogueira GJ, Levin E (1971) Role of the pia mater in the transfer of substances in and out of the cerebrospinal fluid. Exp Brain Res 13:294–305
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Dedicated to Professor T.H. Schiebler on the occasion of his 65th birthday
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Krisch, B. Ultrastructure of the meninges at the site of penetration of veins through the dura mater, with particular reference to Pacchionian granulations. Cell Tissue Res. 251, 621–631 (1988). https://doi.org/10.1007/BF00214011
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DOI: https://doi.org/10.1007/BF00214011