Abstract
Otosclerosis is a disease of the otic capsule that is caused by abnormal resorption and redeposition of bony tissue. Sixty-two unrelated Japanese patients exhibiting clinical otosclerosis were typed for HLA-A, -B,-C antigens. Twenty-one of the patients were also typed for DR antigens. The frequency of HLA-Aw33 was significantly higher in otosclerosis patients than in the control group (24.2% vs 9.5%). This finding suggests that the presence of HLA-Aw33 antigens may be related to an increased susceptibility to otosclerosis or to its clinical outcome.
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References
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Miyazawa, T., Tago, C., Ueda, H. et al. HLA associations in otosclerosis in Japanese patients. Eur Arch Otorhinolaryngol 253, 501–503 (1996). https://doi.org/10.1007/BF00179958
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DOI: https://doi.org/10.1007/BF00179958