Summary
This study examined the relationship between cognitive function, tumor malignancy, adjunctive therapy, and lesion lateralization following surgery for intracerebral glioma. Neuropsychological test battery results showed no difference between patients with highly malignant gliomas and those with less malignant gliomas, but differences were found for tumor lateralization and type of therapy. Scores on a test of graphomotor speed were lowest for patients who had received radiation or a combination of radiation and chemotherapy, regardless of lesion location. Other test results did not differ according to type of prior treatment but were related instead to tumor lateralization. Left hemisphere lesions were associated with lower scores on verbal tests, while right hemisphere lesions were related to lower scores on a test of facial recognition.
These findings suggest that neuropsychological tests may be useful for distinguishing between the diffuse side effects of brain tumor therapy and the focal effects of tumors and surgery on brain functions. In addition, it appears that any differences in cognitive function due to tumor malignancy are eliminated or reduced following surgical intervention.
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Anderson SW, Damasio H, Jones RD, Tranel D: Wisconsin Card Sorting Test performance as a measure of frontal lobe damage. J Clin Exp Neuropsychol 13: 909–922,1991
Minski L: The mental symptoms associated with 58 cases of cerebral tumor. J Neurol Psychopathol 13: 330–343,1993
Busch E: Psychical symptoms in neurosurgical disease. Acta Psychiatrica et Neurologica 15: 257–290,1940
Keschner M, Bender MB, Strauss I: Mental symptoms associated with brain tumor: a study of 530 verified cases. JAMA 10:714–718,1938
Lishman WA: Organic psychiatry: The Psychological Consequences of Cerebral Disorder. Boston: Blackwell Scientific Publishers, 1987
Lilja A, Brun A, Salfor LG, Ohman R, Salfor GJW, Hagstadius S, Risberg J: Neuropsychological indexes of a partial frontal syndrome in patients with nonfrontal gliomas. Neuropsychology 6:315–326,1992
Hom J, Reitan RM: Neuropsychological correlates of rapidly vs slowly growing intrinsic cerebral neoplasms. J Clin Neuropsychol 6:309–324,1984
Reitan RM: Psychologic changes associated with aging and with cerebral damage. Mayo Clin Proc 42: 653–673,1967
Maire JP, Coudin B, Guérin J, Caudry M: Neuropsychologic impairment in adults with brain tumors. Am J Clin Onco1 10: 156–162,1987
Lee Y-Y, Nauert C, Glass JP: Treatment-related white matter changes in cancer patients. Cancer 57: 1473–1482,1986
Duffner PK, Cohen ME, Parker MS: Prospective intellectual testing in children with brain tumors. Ann Neurol 23: 575–579,1988
Lee JS, Umsawasdi T, Lee YY, Barkley HT, Murphy WK, Welch S, Valdivieso M: Neurotoxicity in long-term survivors of small cell lung cancer. Int J Radiat Oncol Biol Phys 12: 313–321,1985
Hochberg FH, Slotnick B: Neuropsychologic impairment in astrocytoma survivors. Neurology 30:172–177,1980
Taphoorn MJB, Heimans JJ, Snoek FJ, Lindeboom J, Oosterink B, Wolbers JG, Karim A: Assessment of quality of life in patients treated for low grade glioma: a preliminary report. J Neurol Neurosurg Psychiatry 55: 372–376,1992
Haaland KY, Delaney HD: Motor deficits after left or right hemisphere damage due to stroke or tumor. Neuropsychologia 19:17–27,1981
Anderson SW, Damasio H, Tranel D: Neuropsychological impairments associated with lesions caused by tumor or stroke. Arch Neurol 47: 397–405,1990
Burger PC, Vogel FS, Green SB, Strike TA: Glioblastoma multiforme and anaplastic astrocytoma: pathologic criteria and prognostic implications. Cancer 56:1106–1111,1985
Wechsler D: Wechsler adult intelligence scale-revised. San Antonio: Psychological Corporation, 1981
Larrabee GJ, Trahan DE, Curtiss G, Levin HS: Normative data for the Verbal Selective Reminding Test. Neuropsychology 2:173–182,1988
Benton AL, Hamsher KdeS: Multilingual Aphasia Examination. Iowa City, IA: AJA Associates, 1983
Benton AL, Hamsher KdeS, Varney NR, Spreen O: Contributions to Neuropsychological Assessment. New York: Oxford University Press, 1983
Grove WM, Andreasen NO Simultaneous tests of many hypotheses in exploratory research. J Nerv Ment Dis 170: 3–8, 1982
Hochberg Y: A modification of the T -method of multiple comparisons for a one-way layout with unequal variances. J Am Statist Assoc 71: 200–203,1976
Doehring DC, Reitan RM, Kløve H: Changes in patterns of intelligence test performance associated with homonymous visual field defects. J Nerv Ment Dis 132: 227–233,1961
Scheibel RS, Hannay HJ, Meyers CA: The Category Test in patients with lateralized frontal and nonfrontal glioma. [Abstract] J Clin Exp Neuropsychol 15: 69,1993
Meyers CA, Scheibel RS: Early detection and diagnosis of neurobehavioral disorders associated with cancer and its treatment. Oncology 4:115–122,1990
DeAngelis LM, Delattre J-Y, Posner JB: Radiation-induced dementia in patients cured of brain metastases. Neurology 39:789–796,1989
Van Zomeren AH, Brouwer AH: Head injury and concepts of attention. In: Levin HS, Grafman J, Eisenberg HM (eds) Neurobehavioral Recovery After Head Injury. New York: Oxford University Press, 1987, pp 398–415
Miller N, Satz P, Vischer B: Computerized and conventional neuropsychological assessment of HIV-1-infected homosexual men. Neurology 41:1608–1616,1991
Meyers CA, Boake C: Neurobehavioral disorders in brain tumor patients: rehabilitation strategies. Cancer Bull 45: 362–364,1993
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Scheibel, R.S., Meyers, C.A. & Levin, V.A. Cognitive dysfunction following surgery for intracerebral glioma: influence of histopathology, lesion location, and treatment. J Neuro-Oncol 30, 61–69 (1996). https://doi.org/10.1007/BF00177444
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DOI: https://doi.org/10.1007/BF00177444