Abstract
We examined a possible correlation between clinical signs of early pseudoexfoliation (PSX) syndrome related to pigment dispersion and iris stroma atrophy and morphological alterations of the lens capsule. 63 anterior lens capsules (30 PSX suspects, 3 pre-PSX, 10 PSX, 20 controls) were studied by transmission and immuno-electron microscopy (TEM). In 20 PSX suspect and 3 pre-PSX capsulotomy specimens, TEM revealed a precapsular layer (0.1–11 μm in thickness) composed of microfibrils, amorphous material, and granular inclusions. The incidence of this fibrillar layer was significantly higher (p=0.001) in PSX suspect and pre-PSX eyes than in controls (5 positive). Ultrastructural and immunohistochemical similarities of the fibrillar surface network in PSX suspect and typical PSX specimens indicate that the precapsular layer may represent a precursor of PSX. The beginning PSX process in the eye is obviously indicated by certain clinical signs.
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Aasved H (1973) Incidence of defects in the pigmented pupillary ruff in eyes with and without fibrillopathia epitheliocapsularis. Acta Ophthalmol 51:710–715
Bartholomew RS (1971) Pseudo-capsular exfoliation in the Bantu of South Africa I. Early or pre-granular clinical stage. Br J Ophthalmol 55:693–699
Cohen AI (1965) The electron microscopy of the normal human lens. Invest Ophthalmol 4:433–446
Dark AJ, Streeten BW (1990) Precapsular film on the aging human lens: precursor of pseudoexfoliation? Br J Ophthalmol 74:717–722
Dark AJ, Streeten BW, Jones D (1969) Accumulation of fibrillar protein in the aging human lens capsule. Arch Ophthalmol 82:815–821
Jerndal T (1985) The initial stage of the exfoliation syndrome. Acta Ophthalmol 63 [Suppl 73]:65–66
Konstas AG, Marshall GE, Lee WR (1990) Immunogold localisation of laminin in normal and exfoliative iris. Br J Ophthalmol 74:450–457
Krause U, Helve J, Forsius H (1973) Pseudoexfoliation of the lens capsule and liberation of iris pigment. Acta Ophthalmol 51:39–46
Küchle M, Schönherr U, Dieckmann U, the “Erlanger Augenblatter-Group” (1989) Risk factors for capsular breaks and vitreous loss in extracapsular cataract surgery. Fortschr Ophthalmol 86:417–421
Mapstone R (1981) Pigment release. Br J Ophthalmol 65:258–263
Naumann GOH, Küchle M, Schönherr U, the “Erlanger Augenblatter-Group” (1989) Pseudoexfoliation syndrome as a risk factor for vitreous loss in extracapsular cataract surgery. Fortschr Ophthalmol 86:543–545
Norn MS (1971) Iris pigment defects in normals. Acta Ophthalmol 49:887–894
Prince AM, Ritch R (1986) Clinical signs of the pseudoexfoliation syndrome. Ophthalmology 93:803–807
Prince AM, Streeten BW, Ritch R, Dark AJ, Sperling M (1987) Preclinical diagnosis of pseudoexfoliation syndrome. Arch Ophthalmol 105:1076–1082
Roh YB, Ishibashi T, Ito N, Inomata H (1987) Alteration of microfibrils in the conjunctiva of patients with exfoliation syndrome. Arch Ophthalmol 105:978–982
Roth M, Epstein DL (1980) Exfoliation syndrome. Am J Ophthalmol 89:477–481
Schlötzer-Schrehardt U, Küchle M, Naumann GOH (1991) Electron microscopic identification of pseudoexfoliation material in extrabulbar tissue. Arch Ophthalmol 109:565–570
Schlötzer-Schrehardt U, Dörfler S, Naumann GOH (1992) Immunogold localization of basement membrane components in pseudoexfoliation material. Curr Eye Res (in press)
Schlötzer-Schrehardt U, Küchle M, Dörfler S, NaumannGOH (1991) Ultrastructural findings of pseudoexfoliation (PSX) material in eyelid-skin of PSX and PSX suspect patients. Invest Ophthalmol Vis Sci 32 (Suppl):857
Tarkkanen A (1962) Pseudoexfoliation of the lens capsule. Acta Ophthalmol [Suppl 71]:9–98
Wishart PK, Spaeth GL, Poryzees EM (1985) Anterior chamber angle in the exfoliation syndrome. Br J Ophthalmol 69:103–107
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This study was supported by Deutscher Akademischer Austauschdienst (No. 325/311/023/1) and Deutsche Forschungsgemeinschaft (Na 55/5-2)
Offprint requests to: U. Schlötzer-Schrehardt
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Tetsumoto, K., Schlötzer-Schrehardt, U., Küchle, M. et al. Precapsular layer of the anterior lens capsule in early pseudoexfoliation syndrome. Graefe's Arch Clin Exp Ophthalmol 230, 252–257 (1992). https://doi.org/10.1007/BF00176300
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DOI: https://doi.org/10.1007/BF00176300