Abstract
An experimental rat model for the study of venous pain induced by 4-hydroxy-cyclophosphamide (4-OH-CP) derivatives was developed and validated. Using various metabolites and chemical variants of 4-OH-CP it was found that pain induction was independent from the compound's alkylating activity but possibly related to the spontaneous generation of minute amounts of acrolein from the 4-OH-CP molecule. Accordingly, the pain could be prevented by the addition of thiol compounds such as mesna or N-acetyl-cysteine.
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Brock N, Niemeyer U, Pohl J, Scheffler G: Stabilized primary metabolites of oxazaphosphorine cytostatics with high cytotoxic specificity and cancerotoxic selectivity needing no enzymatic activation. Third NCI-EORTC Symposium on New Drugs in Cancer Therapy, Brussels, Abstract 47, 1981
Asta-Werke AG Degussa Pharma Gruppe, Mafosfamide, Summary for Investigators, 1984
Bruntsch U, Groos G, Hiller TA, Wandt H, Tigges F-J, Gallmeier WM: Phase-I study of mafosfamide-cyclohexylamine (ASTA Z 7557; NSC 345 842) and limited phase I data on mafosfamide-lysine (Abstract) Invest New Drugs 3:297, 1985
Niemeyer U, Engel J, Scheffler G, Molge K, Sauerbier D, Weigert W: Chemical characterization of ASTA Z 7557 (INN mafosfamide, CIS-4-sulfoethylthio-cyclophosphamide), a stable derivative of 4-hydroxy-cyclophosphamide. Invest New Drugs 2:133–139, 1984
Hilgard P, Peukert M, Pohl J: α/β-Triglycidylurazol (TGU, NSC 332488, INN Anaxirone); a new chemotherapeutic agent. Cancer Treat Rev 11:115–120, 1984
Brock N, Hilgard P, Pohl J, Ormstad K, Orrenius, S: Pharmacokinetics and Mechanism of Action of Detoxifying Low-Molecular-Weight Thiols. J Cancer Res Clin Oncol 108:87–97, 1984
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Hilgard, P., Pohl, J. Short communication: Cause and prevention of mafosfamide-induced venous pain. Invest New Drugs 4, 373–376 (1986). https://doi.org/10.1007/BF00173510
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DOI: https://doi.org/10.1007/BF00173510