Summary
Of 116 chitinolytic actinomycetes, previously isolated from marine sediments, 85 were found to possess antimicrobial activity. A high correlation was noted between chitinolysis and bioactivity. A majority of them suppressed the growth of Gram-positive bacteria but only a few inhibitedGram-negative strains and almost one-half of them exhibited antimyccotic activity. Several of the last group yielded polyenes of which heptaenes were the most commonly occurring ones. Other strains synthesized detectable amounts of \-lactam antibiotics. It is suggested that chitinolysis may serve as an indicator of potential bioactivity among marine actinomycetes.
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Becker B, Lechevalier MP, Gordon RE, Lechevalier HA (1964) Rapid differentiation between Nocardia and Streptomyces by paper chromatography of whole cell hydrolysates. Appl Microbiol 12:421–423
Cross T (1982) Actinomycetes: a continuing source of new metabolites. Dev Ind Microbiol 23:1–18
Hsu SC, Lockwood JL (1975) Powdered chitin agar as a selective medium for the enumeration of actinomycetes in water and soil. Appl Microbiol 29:422–426
Hütter R (1982) Design of culture media capable of provoking wide gene expression. In: Bu'Lock JD, Nisbet LJ, Winstanley DJ (eds) Bioactive microbial products: search and discovery. Academic Press, New York, pp 37–50
Jones RN, Wilson HW, Novick WJ Jr (1982) In vitro evaluation of pyridine-2-azo-p-dimethylaniline cephalosporin, a new diagnostic chromogenic reagent, and comparison with nitrocefin, cephacetrile, and other beta-lactam compounds. J Clin Microbiol 15:677–683
Okami Y (1986) Marine microorganisms as a source of bioactive agents. Microb Ecol 12:65–78
Okami Y, Hotta K (1988) Search and discovery of new antibiotics. In: Goodfellow M, Williams ST, Modarski M (eds) Actinomycetes in biotechnology. Academic Press, New York, pp 33–67
Okazaki T, Okami Y (1972) Studies on marine microorganisms. II. Actinomycetes in Sagami Bay and their antibiotic substances. J Antibiot 25:461–466
Pisano MA, Sommer MJ, Lopez MM (1986) Application of pretreatments for the isolation of bioactive actinomycetes from marine sediments. Appl Microbiol Biotechnol 25:285–288
Pisano MA, Sommer MJ, Brett BP (1987) Hudson River sediments as a source of actinomycetes exhibiting antifungal activity. Appl Microbiol Biotechnol 27:214–217
Pisano MA, Sommer MJ, Brancaccio L (1989) Isolation of bioactive actinomycetes from marine sediments using rifampicin. Appl Microbiol Biotechnol 31:609–612
Sykes RB, Wells JS (1985) Screening for \-lactam antibiotics in nature. J Antibiot 38:119–121
Tunac JB, Graham BD, Dobson WE, Lenzini MD (1985) Fermentation by a new daunomycin-producing organism, Streptomyces insignis ATCC 31913. Appl Environ Microbiol 49:265–268
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Pisano, M.A., Sommer, M.J. & Taras, L. Bioactivity of chitinolytic actinomycetes of marine origin. Appl Microbiol Biotechnol 36, 553–555 (1992). https://doi.org/10.1007/BF00170202
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DOI: https://doi.org/10.1007/BF00170202