Abstract
Ten isolates of Penicillium marneffei and eight of Pythium insidiosum were tested for their in vitro sensitivity to amphotericin B, hamycin (a polyene heptaene), two water-soluble analogs of amphotericin B and hamycin, namely, JAI-Amb, and JAI-hamycin, 5-fluorocytosine, fluoconazole, itraconazole, ketoconazole and miconazole. Itraconazole manifested the strongest activity against all of the 10 isolates of P. marneffei and would be the drug of choice in the treatment of penicilliosis due to P. marneffei. The polyene antibiotics amphotericin B and hamycin and their water-soluble analogs showed no appreciable activity against P. insidiosum. Pytium insidiosum isolates were sensitive to fluconazole, ketoconazole, and miconazole.
Miconazole exhibited the strongest in vitro activity against all of the 8 isolates of P. insidiosum, followed by ketoconazole.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
AncelleT., Dupouy-CametJ., PujolF., NasifX., FerradiniL., ChoudatL., BievredeC., DupontB., DrouhetE. and LapierreJ. (1988): Un cas de penicilliose disseminee a Penicillium marneffei chez un malade atteint d'un syndrome immunodeficitaire acquis - La Presse Med. 17: 1095–1096.
AncelleT., Dupouy-CarnetJ., PujolF., NassifX., FerradiniL. and LapierreJ. (1988): Un cas de penicilliose disseminee a Penicillium marneffei chez un malade atteint de Sida - Bul. Soc. Fr. Mycol. Med. 17: 73–76.
ChanJ.K.C., TsangD.N.C. and WongD.K.K. (1989): Penicillium marneffei in bronchoalveolar lavage fluid- Acta Cytol. 4: 523–526.
Coen M., Viviani M.A., Rizzardini G., Tortorano A.M., Bonaccorso C. and Quirino T. (1989): Disseminated infection due to Penicillium marneffei in an HIV positive patient - Abstract No. MBP 94, In: Abstracts of the Fifth International Conference on AIDS, Ottawa, Canada.
DeCockA.W.A.M., MendozaL., PadhyeA.A., AjelloL. and KaufmanL. (1987): Pythium insidiosum sp. nov., the etiologic agent of pythiosis - J. Clin. Microbiol. 25: 344–349.
DengZ. and ConnorD.H. (1985): Progressive disseminated penicilliosis caused by Penicillium marneffei - Am. J. Clin. Pathol. 84: 323–327.
DengZ., RibasJ.L., GibsonD.W. and ConnorD.H. (1988): Infections caused by Penicillium marneffei in China and Southeast Asia: review of eighteen published cases and report of four more Chinese cases - Rev. Infect. Dis. 10: 640–652.
DiSalvoA.F., FicklingA.M. and AjelloL. (1973): Infection caused by Penicillium marneffei: description of first natural infection in man - Am. J. Clin. Pathol. 60: 259–263.
HulshofC.M.J., ZantenVanR.A.A., SluitersJ.F., EndeVanderM.E., SamsonR.S., ZondevanP.E. and WagenvoortJ.H.T. (1990): Penicillium marneffei infection in an AIDS patient - Eur. J. Clin. Microbiol. Infect. Dis. 9: 370.
JayanetraP., NitiyanantP., AjelloL., PadhyeA.A., LolekhaS., AtichartakarnV., VathesatogitP., SathaphatayavongsB. and PrajaktamR. (1984): Penicilliosis marneffei in Thailand: report of five human cases - Am. J. Trop. Med. Hyg. 33: 637–644.
PautlerK.B., PadhyeA.A. and AjelloL. (1984): Imported Penicillium marneffei in the United States: report of a second human infection. Sabouraudia: J. Med. Vet. Mycol. 22: 433–438.
PetoT.E.A., BullR., MillandP.R., MackenzieD.W.R., CampbellC.K., HainesM.E. and MitchellR.G. (1988): Systemic mycosis due to Penicillium marneffei in a patient with antibody to human immunodeficiency virus - J. -Infect. 16: 285–290.
PiehlM.R., KaplanR.L. and HaberM.H. (1988): Disseminated penicilliosis in a patient with acquired immunodeficiency syndrome - Arch. Pathol. Lab. Med. 112: 1262–1264.
RomanaC.A., SternM., ChovinS., DrouhetE. and PaysJ.F. (1989): Penicilliose pulmonaire a Penicillium marneffei chez un patient atteint d'un syndrome immunodeficitaire acquis deuxieme cas Francais -Bull. Soc. Fr. Mycol. Med. 18: 311–316.
SathapatayavongsB., LeelachaikulP., PrachaktamR., AtichartakarnV., SriphojanartS., TrairatvorakulP., JirasirithamS., NontasutS., EurvilaichitC. and FlegelT. (1989): Human pythiosis associated with thalassemia hemoglobinopathy syndrome - J. Infect. Dis. 159: 274–280.
SathapatayavongsB., DamrongkitchairpornS., SaengdithaP., KiatboonsriS. and JayanetraP. (1989): Disseminated penicilliosis associated with HIV infection - J. Infect. 19: 84–85.
SekhonA.S. and FunkA. (1977): In vitro inhibitory studies of phacidin against some dermatophytes, opportunistic and systemic fungi and yeasts pathogenic to man - J. Antimicrob. Chemother. 3: 95–100.
ShadomyS., Espinel-IngroffA. and CartwrightR.Y. (1985): Laboratory studies with antifungal agents: susceptibility tests and bioassays - pp. 991–999 - In: Manual of Clinical Microbiology, 4th ed., American Society for Microbiology, Washinghton D.C.
SoS., ChauP., JonesB.M., WuP., PunK., LamW. and LawtonJ.W.M. (1985): A case invasive penicilliosis in Hong Kong with immunologic evaluation - Am. J. Res. Dis. 131: 662–665.
TanphaichitraD. (1989): Tropical disease in the immunocompromised host: melioidosis and pythiosis - Rev. Infect. Dis. 11: S1629-S1643.
TamphaichitraD., SrimuangS. and SiristonpunY (1988): Phycomycosis, human pythiosis and penicilliosis in the abnormal hosts: cellular immunity and current therapy - J. Acquir. Immune. Defic. Syndr. 1: 202–203.
TsangD.N.C., ChanJ.K.C., LauY.T., LimW., TseC.H. and ChanN.K. (1988): Penicillium marneffei infection: an underdiagnosed disease? Histopathol. 13: 311–318.
TsangD.N.C., LiP.C.K., TsuiM.S., LauY.T., MaK.F. and YeohE.K. (1991): Penicillium marneffei: another pathogen to consider in patients infected with human immunodeficiency virus - Rev. Infect. Dis. 13: 766–767.
VanCutsemJ. and VanGervenF. (1991): Activite antifongique in vitro de l'itraconazole sur les champignons filamenteux opportunistes. Traitment de la keratomycose et de la penicilliose experimentales - J. Mycol. Med. 118: 10–15.
YuenW.C., ChanY.F., LokeS.L., SetoW.H., PoonG.P. and WongK.K. (1986): Chronic lymphadenopathy caused by Penicillium marneffei: a condition nimicking tuberculous lymphadenopathy -Br. J. Surg. 73: 1007–1008.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sekhon, A.S., Padhye, A.A. & Garg, A.K. In vitro sensitivity of Penicillium marneffei and Pythium insidiosum to various antifungal agents. Eur J Epidemiol 8, 427–432 (1992). https://doi.org/10.1007/BF00158578
Issue Date:
DOI: https://doi.org/10.1007/BF00158578