Abstract
The aim of this double-blind randomized study was to assess the effect of subconjunctival methylprednisolone hemisuccinate (MH) on the recovery of the blood aqueous barrier (BAB) following uncomplicated cataract surgery performed by the same surgeon in normal eyes. Fifty eyes of fifty patients (28 female, 22 male, mean age 72.3 ± 11.2 years) were randomized into two groups: group 1 received a subconjunctival injection of MH (40 mg in 0.5 cc) at the end of the surgery and group 2 did not. All patients were free of other ocular or systemic diseases known to alter the BAB and were not taking any anti-inflammatory medications. Postoperative treatments were similar in both groups. The patients were submitted to laser flare photometry 30 minutes to one hour after mydriasis with a drop of tropicamide preoperatively and on the first, second and seventh day and then one month and six months following surgery. No difference in aqueous flare was seen between the two groups on any of postoperative visits. These data suggest that subconjunctival MH has no beneficial effect in postoperative BAB permeability following uncomplicated cataract surgery in normal eyes.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Ferguson VMG, Spalton DJ. Continued breakdown of the blood aqueous barrier following cataract surgery. Br J Ophthalmol 1992; 76: 453–6.
Miyake K. Fluorophotometric evaluation of the blood ocular barrier function following cataract surgery and intraocular lens implantation. J Cataract Refr Surg 1988; 14: 510–8.
Oshika T, Araie M, Masuda K. Diurnal variations of aqueous flare in normal human eyes measured with laser flare-cell meter. Jpn J Ophthalmol 1988; 32:143–50.
Sawa M, Tsurimaki Y, Tsuru T, Shimizu H. New quantitative method to determine protein concentrations and cell number in aqueous in vivo. Jpn J Ophthalmol 1988; 32: 132–42.
Shah SM, Spalton DJ, Taylor JC. Correlations between laser flare measurements and anterior chamber protein concentrations. Invest Ophthalmol Vis Sci 1992; 33:2878–84.
El-Maghraby A, Marzouki A, Mohammed T, Soucheck J, Van der Karr M. Reproducibility and validity of laser flare/cell meter measurements as an objective method of assessing intraocular inflammation. Arch Ophthalmol 1992; 110:960–2.
Shah SM, McHugh JD, Spalton DJ. The effects of subconjunctival betamethasone on the blood aqueous barrier following cataract surgery: a double-blind randomised prospective study. Br J Ophthalmol 1992; 76: 475–8.
Oshika T, Kato S. Changes in aqueous flare and cells after mydriasis. Jpn J Ophthalmol 1989; 33: 271–8.
Oshika T, Kato S, Sawa M, Masuda K. Aqueous flare intensity and age. Jpn J Ophthalmol 1989; 33: 237–42.
Maurice DM, Ota Y. The kinetics of subconjunctival injections. Jpn J Ophthalmol 1978; 22: 95–100.
Wine N, Gornall AG, Basu PK. The ocular uptake of subconjunctival injected 14C hydrocortisone. Am J Ophthalmol 1964; 58: 362–6.
McCartney HJ, Drysdale IO, Gornall AG, Basu PK. An autoradiographic study of the penetration of subconjunctivally injected hydrocortisone into the normal and inflamed rabbit eye. Invest Ophthalmol Vis Sci 1965; 4: 297–9.
Jain MR, Srisvastava S. Ocular penetration of hydrocortisone and dexamethasone into the aqueous humour after subconjunctival injection. Trans Ophthalmol Soc UK 1978; 98: 63–5.
McGhee CNJ, Watson DJ, Midgley JM, Noble MJ, Dutton GN, Fern AI. Penetration of synthetic corticosteroids into human aqueous humour. Eye 1990; 4: 526–30.
Nishi O. Fibrinous membrane formation on the posterior chamber lens during the early postoperative period. J Cataract Refract Surg 1988; 14: 73–7.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nicolás, T., Benítez del Castillo, J.M., Díaz, D. et al. Effects of subconjunctival methylprednisolone on the blood aqueous barrier following cataract surgery. Int Ophthalmol 19, 235–238 (1995). https://doi.org/10.1007/BF00132692
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00132692