Plasma-sprayed HA-coatings used for orthopaedic surgery can contain different percentages of crystalline phase. The influence of the amount of crystalline and amorphous phase on the biological properties of coatings is not known. The aim of this study is to determine the effect of this coating characteristic on mammalian cell functions in vitro. It appears that 100% crystalline coatings have an inhibiting effect on cell proliferation and on alkaline phosphatase activity. A direct contact of the cells with the material is necessary to obtain this effect. The material evolves during the period of culture. Poorly crystalline coatings dissolve during the period of culture and the roughness parameters change during the same period.
Article PDF
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
References
S. D. COOK, K. A. THOMAS, J. F. KAY and M. JARCHO, Clin. Orthopaedic Related Res. 232 (1988) 225.
E. J. EVANS, Biomaterials 12 (1991) 574.
J. C. METCALFE, J. P. MOORE, G. A. SMITH and T. R. HESKETH, Brit. Med. Bull. 42 (1986) 405.
B. ALBERT, D. BRAY, J. LEWIS, M. RAFF, K. ROBERTS and J. D. WATSON, in “Molecular biology of the cell” (Garland Publishers, New York, 1989) p. 682.
G. T. SYFESTAD, M. WELTZHANDER and A. I. CAPLAN, Devl Biol. 110 (1985) 275.
P. FRAYSSINET, P. BONNEVIALLE, A. AUTEFAGE and G. BONEL, in “Limb salvage-major reconstruction in oncologic and nontumoral conditions”, edited by F. LANGLAIS and B. TOMENO (Springer-Verlag, Berlin, 1990) p. 169.
J. A. MCATEER and W. H. J. DOUGLAS, Meth. Enzymol. LVIII (1979) 132.
M. ADOLPHE, in “Culture de cellules animales. Méthodologies applications”, edited by M. ADOLPHE and G. BARLOVATZ-MEIMON (Editions INSERM, Paris, 1988) p. 1.
R. W. EVANS, H. S. CHEUNG and D. J. MCCARTY, Clin. Res. 30 (1982) 805A.
M. J. BERRIDGE and R. F. IRVINE, Nature 312 (1982) 315.
A. R. MEANS and J. R. DEDHAM, Nature 285 (1980) 73.
P. G. MITCHELL, W. J. PLEDGER and H. S. CHEUNG, J. Biol. Chem. 264 (1989) 14071.
M. K. BENNETT and A. WEEDS, Brit. Med. Bull. 42 (1986) 385.
M. DARD, Bull. Group Internat. Recherche Sci. Stomatol. Odontol. 35 (1991) 209.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Frayssinet, P., Tourenne, F., Rouquet, N. et al. Comparative biological properties of HA plasma-sprayed coatings having different crystallinities. J Mater Sci: Mater Med 5, 11–17 (1994). https://doi.org/10.1007/BF00121147
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00121147