A hospital-based case-control study of renal cell cancer was conducted in northern Italy betwen 1986 and 1989, with 240 cases of renal cell cancer (150 males and 90 females), and 665 controls (445 males and 220 females) chosen on the basis of age, sex, and area of residence. No associations were found between renal cell cancer and: body mass index (BMI); number of cigarettes smoked; age at starting to smoke; years of smoking; consumption of wine, beer, spirits, coffee, decaffeinated coffee; tea; intake of animal protein, fruits, and vegetables; various resproductive factors; hormonal use; sexual habits; sexually transmitted diseases; or selected occupational exposures. The odds ratio (OR) was above unity in smokers (OR=1.34 for ≥15 cigarettes/day), but the trends in risk with dose or duration were not statistically significant. Significant positive associations were found between renal cell cancer and sources of fat intake, especially margarine (OR for highest vs lowest intake = 1.71), and oils (OR=1.89) whereas carrot intake showed a negative association (OR=0.62). Also, a history of nephrolithiasis and multiple episodes of cystitis showed weak positive associations (OR=2.00, 95 percent confidence interval (CI) 1.07–3.73; and OR=1.60, 95 percent CI 0.95–2.70, respectively).
Address reprint requests to Dr Talamini. The work was conducted with the contribution of the Italian Association for Cancer Research, Milan, Italy and the CNR (Italian National Research Council) Applied Projects “Oncology” (Contract n. 85.02209.44).
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References
Morrison AS, Cole P. Urinary tract cancer. In: Schottenfeld D and Fraumeni JFJr, eds. Cancer Epidemiology and Prevention, Philadelphia: WB Saunders, 1982; 54: 925–37.
Devesa SS, Silverman DT, Young JLJr, et al. Cancer incidence and mortality trends among whites in the United States, 1947–84. JNCI 1987; 79: 701–70.
Ries LG, Pollack ES, Young JLJr. Cancer patient survival: surveillance, epidemiology and end results program 1973–79. JNCI 1983: 70: 693–705.
Decarli A, LaVecchia C, Cislaghi C, Fasoli M, Mezzanotte G, Negri E. Cancer mortality in Italy, 1955–1979: effects of age,, birth cohort and period of death. Monografie Lega Italiana per la Lotta Contro i Tumori (Milano) 1986; 4: 54–5.
Levi F, Maisonneuve P, Filiberti R, LaVecchia C, Boyle P. Cancer incidence and mortality in Europe. Med Soc Prev 1989; 2 (Suppl): 1–83.
Cislaghi C, Decarli A, LaVecchia C, Laverda N, Mezzanotte G, Smans M. Data, Statistics and Maps on Cancer Mortality, Italy 1975–1977. Bologna: Pitagora Editrice, 1986: 458–67.
McLaughlin JK, Schuman LM. Epidemiology of renal cell carcinoma. In: Lilienfeld AM, ed. Reviews in Cancer Epidemiology. Vol. 2. New York: Elsevier, 1983: 171–210.
Wynder EL, Mabuchi K, Whitmore WFJr. Epidemiology of adenocarcinoma of the kidney. JNCI 1974; 53: 1619–34.
McLaughlin JK, Mandel JS, Blot WJ, Schuman LM, Mehl ES, Fraumeni JFJr. A population-based case-control study of renal cell carcinoma. JNCI 1984; 72: 275–84.
Kahn HA. The Dorn study of smoking and mortality among U.S. veterans: report on eight and one-half years of observation. Natl Cancer Inst Monogr 1966: 19: 1–27.
Hammond EC. Smoking in relation to the death rates of one million men and women. Natl Cancer Inst Mongr 1966; 19: 127–204.
Weir JM, Dunn JGJr. Smoking and mortality: a prospective study. Cancer 1970; 25: 105–12.
Bennington JL, Laubscher FA. Epidemiologic studies on carcinoma of the kidney. I. Association of renal adeno-carcinoma with smoking. Cancer 1968; 21: 1069–71.
Brownson RC. A case-control study of renal cell carcinoma in relation to occupation, smoking, and alcohol consumption. Arch Environ Health 1988; 43: 238–41.
Doll R, Peto R. Mortality in relation to smoking: 20 years' observations on male British doctors. Br Med J 1976; 2: 1525–36.
Schwartz D, Flamant R, Lellouch J, Denoix PF. Results of a French survey on the role of tobacco, particularly inhalation, in different cancer sites. JNCI 1961; 26: 1085–108.
Armstrong B, Garrod A, Doll R. A retrospective study of renal cancer with special reference to coffee and animal protein consumption. Br J Cancer 1976; 33: 127–36.
Yu MC, Mack TM, Hanisch R, Cicioni C, Henderson BE. Cigarette smoking, obesity, diuretic use, and coffee consumption as risk factors for renal cell carcinoma. JNCI 1986; 77: 351–56.
McCredie M, Ford JM, Stewart JH. Risk factors for cancer of the renal parenchyma. Int J Cancer 1988; 42: 13–6.
Goodman MT, Morgenstern H, Wynder EL. A case-control study of factors affecting the development of renal cell cancer. Am J Epidemiol 1986; 124: 926–41.
Jensen OM, Knudsen JB, McLaughlin JK, Sørensen BL. The Copenhagen case-control study of renal pelvis and ureter cancer: role of smoking and occupational exposures. Int J Cancer 1988; 41: 557–61.
Ross RK, Paganini-Hill A, Landolph J, Gerkins V, Henderson BE. Analgesics, cigarette smoking, and other risk factors for cancer of the renal pelvis and ureter. Cancer Res 1989; 49: 1045–8.
McCredie M, Stewart JH, Ford JM, MacLennan RA. Phenacetin-containing analgesics and cancer of the bladder or renal pelvis in women. Br J Urol 1983; 55: 220–4.
Asal NR, Geyer JR, Risser DR, Lee ET, Kadamani S, Cherng N. Risk factors in renal cell carcinoma. I. Methodology, demographics, tobacco beverage use, and obesity. Cancer Dect Prev 1988; 11: 359–77.
Whittemore AS, Paffenbarger RSJr, Anderson K, Lee JE. Early precursors of site-specific cancers in college men and women. JNCI 1985; 74: 43–51.
Hinds MW, Kolonel LN, Lee J, Hirohara T. Associations between cancer incidence and alcohol/cigarette consumption among five ethnic groups in Hawaii. Br J Cancer 1980; 41: 929–40.
McLaughlin JK, Blot WJ, Mehl ES, Stewart PA, Venable FS, Fraumeni JFJr. Petroleum-related employment and renal cell cancer. J Occup Med 1985; 27: 672–4.
Redmond CK, Ciocco A, Lloyd JW, et al. Longterm mortality study of steel-workers. VI. Mortality from malignant neoplasms among coke oven workers. J Occup Med 1972; 14: 621–9.
Kolonel LN. Association of cadmium with renal cancer. Cancer 1976; 37: 1782–7.
Maclure M. Asbestos and renal adenocarcinoma: a casecontrol study. Environ Res 1987; 42: 353–61.
Hanis NM, Shallenberger LG, Donaleski DL, et al. A retrospective mortality study of workers in three major U.S. refineries and chemical plants. J Occup Med 1985; 27: 283–92.
Cooperativa Nuova Alimentazione (Co.N.Al.). ABC per l'Educazione Alimentare. Manuale. Milan: CLESAV, 1983.
Fidanza F, Liguori G. Nutrizione Umana. Napoli: Idelson, 1984: 677–726.
Breslow NE, Day NE. Statistical Methods in Cancer Research: the Analysis of Case-control Studies. Lyon: International Agency for Research on Cancer, 1980; IARC publication no. 32.
Mantel N, Haenszel W. Statistical aspects of analysis of data from retrospective studies of disease. JNCI 1959; 22: 719–48.
GLIM System, Rel. 3. Oxford: Numerical Algorithms Group.
Mantel N. chi-square tests with one degree of freedom: extension of the Mantel-Haenszel procedure. J Am Stat Assoc 1963; 58: 690–700.
Maclure KM, MacMahon B. A case-control study of renal adenocarcinoma (Abstract). Am J Epidemiol 1985; 122: 520.
Negri E, Pagano R, Decarli A, LaVecchia C. Body weight and prevalence of chronic diseases. J Epidemiol Community Health 1988; 42: 24–9.
Armstrong B, Doll R. Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer 1975; 15: 617–31.
Hirayama T. Diet and cancer. Nutr Cancer 1979; 1: 67–81.
Middleton B, Byers T, Marshall J, Graham S. Dictary vitamin A and cancer—A multisite case-control study. Nutr Cancer 1986; 8: 107–16.
Pisani P, Berrino F, Macaluso M, Pastorino U, Crosignani P, Baldasseroni A. Carrots, green vegetables and lung cancer: a case-control study. Int J Epidemiol 1986; 15: 463–8.
Willett WC, Polk BF, Underwood BA, et al. Relation of serum vitamins A and E and carotenoids to the risk of cancer. N Engl J Med 1984; 310: 430–4.
LaVecchia C, Negri E, Decarli A, D'Avanzo B, Franceschi S. A case-control study of diet and gastric cancer in Northern Italy. Int J Cancer 1987; 40: 484–9.
Peto R, Doll R, Buckley JD, Sporn MB. Can dietary betacarotene materially reduce human cancer rates? Nature 1981; 290: 201–8.
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Drs Talamini, Barón, Barra, Bidoli, Serraino, and Franceschi are in the Epidemiology Unit, Aviano Cancer Center, Via Pedemontana Occ. 33081 Aviano (PN) Italy. At the time of this work, Dr Barón was a visiting biostatistician from the Department of Preventive Medicine and Biometrics, University of Colorado, Health Science Center, CO, funded by the National Cancer Institute (US) and the Italian National Research Council. Dr Franceschi is also chief of the Hormones and Sexual Factors and Cancer Working Group of the European Organization for Cooperation in Cancer Prevention Studies, Bruxelles, Belgium. Drs La Vecchia and Negri are in the “Mario Negri” Institute for Pharmacological Research, Milan, Italy. Dr La Vecchia is also in the Institute of Social and preventive Medicine, University of Lausanne, Switzerland.
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Talamini, R., Barón, A.E., Barra, S. et al. A case-control study of risk factor for renal cell cancer in northern Italy. Cancer Causes Control 1, 125–132 (1990). https://doi.org/10.1007/BF00053163
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DOI: https://doi.org/10.1007/BF00053163