Abstract
Carcinoembryonic antigen (CEA) is a glycoprotein that has been useful as a tumor marker to predict recurrence in gastrointestinal malignancies, but whose biological function has not been elucidated. With the recent evidence that CEA is a member of the immunoglobulin supergene family, CEA may be involved in intercellular recognition and binding. This review examines the role that CEA plays in the development of mestastases by colorectal carcinoma.
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Supported by grant RO1CA42587 from the U.S. Department of Health and Human Services.
Supported by grants RO1CA44586 and PO1CA44704 from the U.S. Department of Health and Human Services.
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Jessup, M., Thomas, P. Carcinoembryonic antigen: Function in metastasis by human colorectal carcinoma. Cancer Metast Rev 8, 263–280 (1989). https://doi.org/10.1007/BF00047341
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DOI: https://doi.org/10.1007/BF00047341