Skip to main content

Comparative Study of Machine Learning with Novel Feature Extraction and Transfer Learning to Perform Detection of Glaucoma in Fundus Retinal Images

  • Conference paper
  • First Online:
Soft Computing: Theories and Applications

Part of the book series: Advances in Intelligent Systems and Computing ((AISC,volume 1381))

Abstract

Glaucoma detection from fundus retinal images is a difficult task which requires years of practice and expertise in the domain. In this paper, we propose a novel method of statistical feature extraction from fundus retinal images and test its feasibility in glaucoma detection with machine learning algorithms. We combine the results of these algorithms by applying ensemble learning to create one optimized predicted output. We also apply transfer learning and compare the results obtained. The random forest model and ensemble learning model performed better than other conventional models. Using the conventional machine learning algorithms, the highest accuracy, sensitivity and AUC of 83.42%, 74.62% and 0.82, respectively, were obtained by ensemble learning, and the highest specificity of 94.74% was observed in the random forest algorithm. Using the transfer learning algorithms, the best performance was obtained with VGG19 model with AUC 0.8919 followed by GoogLeNet with an AUC of 0.8872.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Cook, C., Foster, P.: Epidemiology of glaucoma: what’s new? Can. J. Ophthalmol. 47(3), 223–226 (2012)

    Article  Google Scholar 

  2. Weinreb, R.N., Aung, T., Medeiros, F.A.: The pathophysiology and treatment of glaucoma: a review. JAMA 311(18), 1901–1911 (2014). https://doi.org/10.1001/jama.2014.3192

    Article  Google Scholar 

  3. Ruengkitpinyo, W., Kongprawechnon, W., Kondo, T., Bunnun, P., Kaneko, H.: Glaucoma screening using rim width based on ISNT rule. In: 6th International Conference of Information and Communication Technology for Embedded Systems (IC-ICTES) IEEE, pp. 1–5 (2015). https://doi.org/10.1109/ictemsys.2015.7110827

  4. Dana, K.J.: Computational texture and patterns: from textons to deep learning. Synth. Lect. Comput. Vis. 8(3), 1–113 (2018)

    MathSciNet  Google Scholar 

  5. Acharya, U.R., Bhat, S., Koh, J.E., Bhandary, S.V., Adeli, H.: A novel algorithm to detect glaucoma risk using texton and local configuration pattern features extracted from fundus images. Comput. Biol. Med. 88, 72–83 (2017)

    Article  Google Scholar 

  6. Singh, A., Dutta, M.K., ParthaSarathi, M., Uher, V., Burget, R.: Image processing based automatic diagnosis of glaucoma using wavelet features of segmented optic disc from fundus image. Comput. Methods Programs Biomed. 124, 108–120 (2016)

    Article  Google Scholar 

  7. Gupta, G.: Algorithm for image processing using improved median filter and comparison of mean, median and improved median filter. Int. J. Soft Comput. Eng. (IJSCE) 1(5), 304–311 (2011)

    Google Scholar 

  8. Kumar, V., Gupta, P.: Importance of statistical measures in digital image processing. Int. J. Emerg. Technol. Adv. Eng. 2(8), 56–62 (2012)

    Google Scholar 

  9. Fumero, F., Alayón, S., Sanchez, J.L., Sigut, J., Gonzalez-Hernandez, M.: RIM-ONE: an open retinal image database for optic nerve evaluation. In: 2011 24th International Symposium on Computer-Based Medical Systems (CBMS), pp. 1–6. IEEE (2011)

    Google Scholar 

  10. Lee, E.J., Han, J.C., Park, D.Y., & Kee, C.: A neuroglia-based interpretation of glaucomatous neuroretinal rim thinning in the optic nerve head. Prog. Retinal Eye Res. 100840 (2020). https://doi.org/10.1016/j.preteyeres.2020.100840

  11. Wankhede, P.R., Khanchandani, K.B.: Optic disc detection using histogram based template matching. In: International Conference on Signal Processing, Communication, Power and Embedded System (SCOPES) (2016). https://doi.org/10.1109/scopes.2016.7955765

  12. Maheshwari, S., Pachori, R.B., Acharya, U.R.: Automated diagnosis of glaucoma using empirical wavelet transform and correntropy features extracted from fundus images. IEEE J. Biomed. Health Inform. 21(3), 803–813 (2016)

    Article  Google Scholar 

  13. Patil, P.N., Bagkavos, D., Wood, A.T.A.: A measure of asymmetry based on a new necessary and sufficient condition for symmetry. Sankhya A 76(1), 123–145 (2013). https://doi.org/10.1007/s13171-013-0034-z

    Article  MathSciNet  MATH  Google Scholar 

  14. Elangovan, P., Nath, M.K., Mishra, M.: Statistical parameters for glaucoma detection from color fundus images. Procedia Comput. Sci. 171, 2675–2683 (2020). https://doi.org/10.1016/j.procs.2020.04.290

    Article  Google Scholar 

  15. Senthil Kumar, T., Helen Prabha, K.: Geometric mean filter with grayscale morphological method to enhance the RNFL thickness in the SD-OCT images. Multimedia Tools Appl. 77(8) (2018)

    Google Scholar 

  16. David, D.S., Jayachandran, A.: A new expert system based on hybrid colour and structure descriptor and machine learning algorithms for early glaucoma diagnosis. Multimedia Tools Appl. 79(7), 5213–5224 (2020)

    Article  Google Scholar 

  17. Dey, A., Dey, K.N.: Automated glaucoma detection from fundus images of eye using statistical feature extraction methods and support vector machine classification. Ind. Interact. Innov. Sci. Eng. Technol. 511–521 (2017). https://doi.org/10.1007/978-981-10-3953-9_49

  18. Dey, A., Bandyopadhyay, S.: Automated glaucoma detection using support vector machine classification method. J. Adv. Med. Med. Res. 11(12), 1–12 (2015). https://doi.org/10.9734/BJMMR/2016/19617

  19. Hagiwara, Y., Koh, J.E.W., Tan, J.H., Bhandary, S.V., Laude, A., Ciaccio, E.J., Acharya, U.R.: Computer-aided diagnosis of glaucoma using fundus images: a review. Comput. Methods Progr. Biomed. 165, 1–12 (2018). https://doi.org/10.1016/j.cmpb.2018.07.012

  20. Sagi, O., Rokach, L.: Ensemble learning: A survey. Wiley Interdisc. Rev. Data Mining Knowl. Discov. 8(4), e1249 (2018). https://doi.org/10.1002/widm.1249

    Article  Google Scholar 

  21. Zilly, J., Buhmann, J.M., Mahapatra, D.: Glaucoma detection using entropy sampling and ensemble learning for automatic optic cup and disc segmentation. Comput. Med. Imaging Graph. 55, 28–41 (2017)

    Article  Google Scholar 

  22. Kim, M., Zuallaert, J., De Neve, W.: Few-shot learning using a small-sized dataset of high-resolution FUNDUS images for glaucoma diagnosis. In: Proceedings of the 2nd International Workshop on Multimedia for Personal Health and Health Care. Association for Computing Machinery, New York, MMHealth, pp. 89–92 (2017)

    Google Scholar 

  23. Krizhevsky, A., Sutskever, I., Hinton, G.E.: Imagenet classification with deep convolutional neural networks. In: Advances in Neural Information Processing Systems, pp. 1097–1105 (2012)

    Google Scholar 

  24. Diaz-Pinto, A., Morales, S., Naranjo, V., et al.: CNNs for automatic glaucoma assessment using fundus images: an extensive validation. BioMed. Eng. OnLine 18, 29 (2019). https://doi.org/10.1186/s12938-019-0649-y

    Article  Google Scholar 

Download references

Acknowledgements

We sincerely thank N.M.S. Chaitanya, S.R. Shruthi Vidya and S. Chaitanya for their assistance in obtaining the fundus image database, preprocessing of the images.

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Ravishyam, D., Samiappan, D. (2021). Comparative Study of Machine Learning with Novel Feature Extraction and Transfer Learning to Perform Detection of Glaucoma in Fundus Retinal Images. In: Sharma, T.K., Ahn, C.W., Verma, O.P., Panigrahi, B.K. (eds) Soft Computing: Theories and Applications. Advances in Intelligent Systems and Computing, vol 1381. Springer, Singapore. https://doi.org/10.1007/978-981-16-1696-9_40

Download citation

Publish with us

Policies and ethics