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Adaptive immunity in the gastrointestinal tract

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Immunological Aspects of Gastroenterology

Part of the book series: Immunology and Medicine Series ((IMME,volume 31))

Abstract

The adaptive arm of the mucosal immune system is superimposed on the innate immune system of the intestine in a series of difficult but interrelated tasks. It must, a) induce efficient and appropriate immune responses to pathogenic microorganisms; b) tolerate the commensal bacterial intestinal and oropharangeal microflora; c) tolerate food and other environmental antigens. Responses of the systemic immune system can originate from or be modified by the mucosa, this is exemplified by the attenuation of systemic immune responses to a protein that has first been fed orally to the animal (oral tolerance).

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Authors
  1. A. J. S. Macpherson
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  2. K. J. Maloy
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  1. University of Nottingham and Queen’s Medical Centre, Nottingham, UK

    Y. R. Mahida

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Macpherson, A.J.S., Maloy, K.J. (2001). Adaptive immunity in the gastrointestinal tract. In: Mahida, Y.R. (eds) Immunological Aspects of Gastroenterology. Immunology and Medicine Series, vol 31. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0790-0_2

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  • DOI: https://doi.org/10.1007/978-94-010-0790-0_2

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