Abstract
Most galactose in the diet is in the form of the disaccharide lactose, which is synthesized in the mammary gland, mainly from glucose. Lactose is the primary carbohydrate source for nursing mammals and it provides about 40% of the energy in human milk. Why lactose evolved as the unique carbohydrate of milk is unclear, especially since most individuals can meet their galactose needs by biosynthesis from glucose. The simultaneous occurrence of calcium and lactose in milk may be of evolutionary significance. Lactose, in contrast to other saccharides, appears to enhance the absorption of calcium1,2. In man, calcium absorption may be associated with the hydrolysis of lactose3.
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Gitzelmann, R., Hansen, R.G. (1980). Galactose metabolism, hereditary defects and their clinical significance. In: Burman, D., Holton, J.B., Pennock, C.A. (eds) Inherited Disorders of Carbohydrate Metabolism. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-9215-3_4
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