Abstract
The development of a “cold-like illness” (CLI) usually requires infection with an upper respiratory virus such as rhinovirus, influenza virus, respiratory syncytial virus, parainfuluenza virus, coronavirus or adenovirus, among others, and the development of sufficient signs, symptoms and pathophysiologies to qualify as being ill based on personal and cultural definitions. A viral upper respiratory tract infection (vURTI) in the absence of overt illness (subclinical vURTI) will not be made manifest to the individual or to observers and, therefore, will not be diagnosed as a CLI. The degree of illness occurring during a vURTI is directly related to the extent of provoked inflammation, which in turn depends on the engagement of antiviral defense systems. Thus, risk factors for CLI can modulate either the vURTI risk by affecting virus exposure and/or susceptibility to infection, or the CLI risk given a vURTI by affecting immunocompetence, the provoked inflammation and/or the interpretation of ilness as a CLI. In this chapter, we review published studies for evidence of CLI risk-modulating factors and report that climate, crowding and perhaps female gender can affect the probability of exposure to vURTI viruses, that extant immunological factors and age can affect the probability of virus infection given exposure, that stress levels (moderated by social environment), health practices (exercise, tobacco and alcohol consumption, sleep efficiency) and genetics contribute to CLI risk most probably by modulating the immune-inflammatory response to infection, and that other factors such as pollution, home environment and certain personality traits affect CLI risk by biasing illness interpretation for a given set of symptoms and signs.
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Keywords
- Respiratory Syncytial Virus
- Otitis Medium
- Negative Life Event
- Respiratory Syncytial Virus Infection
- Common Cold
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Ammer C (1997) The American Heritage® Dictionary of Idioms. Houghton Mifflin Company, Boston, MA
(2003) Ancyclopaedia Britannica Deluxe Edition. Encyclopaedia Britannica, Inc., Chicago, IL
Eccles R (2002) An explanation for the seasonality of acute upper respiratory tract viral infections. Act Otolaryngol 122: 183–191
(2002) Merriam-Webster’s Medical Dictionary. Merriam-Webster, Inc
Eccles R (2005) Understanding the symptoms of the common cold and influenza. Lancet Infect Dis 5: 718–725
Makela MJ, Puhakka T, Ruuskanen O, Leinonen M, Saikku P, Kimpimaki M, Blomqvist S, Hyypia T, Arstila P (1998) Viruses and bacteria in the etiology of the common cold. J Clin Microbiol 36: 539–542
Nokso-Koivisto J, Pitkaranta A, Blomqvist S, Jokinen J, Kleemola M, Takala A, Kilpi T, Hovi T (2002) Viral etiology of frequently recurring respiratory tract infections in children. Clin Infect Dis 35: 540–546
Louie JK, Hacker JK, Gonzales R, Mark J, Maselli JH, Yagi S, Drew WL (2005) Characterization of viral agents causing acute respiratory infection in a San Francisco University Medical Center Clinic during the influenza season. Clin Infect Dis 41: 822–828
van Gageldonk-Lafeber AB, Heijnen ML, Bartelds AI, Peters MF, van der Plas SM, Wilbrink B (2005) A case-control study of acute respiratory tract infection in general practice patients in The Netherlands. Clin Infect Dis 41: 490–497
Winther B, Alper CM, Mandel EM, Doyle WJ, Hendley JO (2007) Temporal relationships between colds, upper respiratory viruses detected by polymerase chain reaction, and otitis media in young children followed through a typical cold Season. Pediatrics 119: 1069–1075
Wald ER, Guerra N, Byers C (1991) Upper respiratory tract infections in young children: duration of and frequency of complications. Pediatrics 87: 129–133
Petersen I, Johnson AM, Islam A, Duckworth G, Livermore DM, Hayward AC (2007) Protective effect of antibiotics against serious complications of common respiratory tract infections: retrospective cohort study with the UK General Practice Research Database. BMJ 335: 982
Nokso-Koivisto J, Hori T, Pitkaranta A (2006) Viral uppre respiratory tract infections in young children with emphasis on acute otitis media. Int J Pediatr Otorhinolaryngol 70: 1333–1342
Winther B, Doyle WJ, Alper CM (2006) A high prevalence of new onset otitis media during parent diagnosed common colds. Int J Pediatr Otorhinolaryngol 70: 1725–1730
Alho OP (2005) Viral infections and susceptibility to recurrent sinusitis. Curr Allergy Asthma Rep 5: 477–481
Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs L, Symington P, O’Toole S, Myint SH, Tyrrell DA et al. (1995) Community study of role of viral infections in exacerbations of asthma in 9–11 year old children. BMJ 310: 1225–1229
Ahmed AH, Nicholson KG, Hammersley VS (1996) The contribution of respiratory viruses to severe exacerbations of asthma in adults. Chest 109: 588
Nicholson KG, Kent J, Hammersley V, Cancio E (1996) Risk factors for lower respiratory complications of rhinovirus infections in elderly people living in the community: prospective cohort study. BMJ 313: 1119–1123
Doyle WJ, Alper CM (2007) Use of diagnostic algorithms and new technologies to study the incidence and prevalence of viral upper respiratory tract infections and their complications in high risk populations. Curr Opin Allergy Clin Immunol 7: 11–16
Jackson GG, Dowling HF, Anderson TO, Riff L, Saporta J, Turck M (1960) Susceptibility and immunity to common upper respiratory viral infections — the common cold. Ann Intern Med 53: 719–738
Jackson GG, Dowling HF, Spiesman IG, Boand AV (1958) Transmission of the common cold to volunteers under controlled conditions. I. The common cold as a clinical entity. AMA Arch Intern Med 101: 267–278
Barrett B, Brown R, Mundt M, Safdar N, Dye L, Maberry R, Alt J (2005) The Wisconsin Upper Respiratory Symptom Survey is responsive, reliable, and valid. J Clin Epidemiol 58: 609–617
Nicholson KG, Kent J, Hammersley V, Cancio E (1997) Acute viral infections of upper respiratory tract in elderly people living in the community: comparative, prospective, population based study of disease burden. BMJ 315: 1060–1064
Boivin G, Hardy I, Tellier G, Maziade J (2000) Predicting influenza infections during epidemics with use of a clinical case definition. Clin Infect Dis 31: 1166–1169
Monto AS, Gravenstein S, Elliott M, Colopy M, Schweinle J (2000) Clinical signs and symptoms predicting influenza infection. Arch Intern Med 160: 3243–3247
Doyle WJ, Gentile DA, Skoner DP (2007) Viral and bacterial rhinitis. Clin Allergy Immunol 19: 177–195
Fox JP, Cooney MK, Hall CE (1975) The Seattle virus watch. V. Epidemiologic observations of rhinovirus infections, 1965–1969, in families with young children. Am J Epidemiol 101: 122–143
Foy HM, Cooney MK, Allan ID, Albrecht JK (1987) Influenza B in households: virus shedding without symptoms or antibody response. Am J Epidemiol 126: 506–515
Johnston SL, Sanderson G, Pattemore PK, Smith S, Bardin PG, Bruce CB, Lambden PR, Tyrrell DA, Holgate ST (1993) Use of polymerase chain reaction for diagnosis of picornavirus infection in subjects with and without respiratory symptoms. J Clin Microbiol 31: 111–117
Nokso-Koivisto J, Kinnari TJ, Lindahl P, Hovi T, Pitkaranta A (2002) Human picornavirus and coronavirus RNA in nasopharynx of children without concurrent respiratory symptoms. J Med Virol 66: 417–420
Graat JM, Schouten EG, Heijnen ML, Kok FJ, Pallast EG, de Greeff SC, Dorigo-Zetsma JW (2003) A prospective, community-based study on virologic assessment among elderly people with and without symptoms of acute respiratory infection. J Clin Epidemiol 56: 1218–1223
Doyle WJ, Skoner DP, Alper CM, Allen G, Moody SA, Seroky JT, Hayden FG (1998) Effect of rimantadine treatment on clinical manifestations and otologic complications in adults experimentally infected with influenza A (H1N1) virus. J Infect Dis 177: 1260–1265
Cohen S, Frank E, Doyle WJ, Skoner DP, Rabin BS, Gwaltney JM, Jr. (1998) Types of stressors that increase susceptibility to the common cold in healthy adults. Health Psychol 17: 214–223
Buchman CA, Doyle WJ, Pilcher O, Gentile DA, Skoner DP (2002) Nasal and otologic effects of experimental respiratory syncytial virus infection in adults. Am J Otolaryngol 23: 70–75
Alper CM, Doyle WJ, Winther B, Owen Hendley J (2008) Upper respiratory virus detection without parent-reported illness in children is virus-specific. J Clin Virol 43: 120–122
Doyle WJ, Alper CM, Buchman CA, Moody SA, Skoner DP, Cohen S (1999) Illness and otological changes during upper respiratory virus infection. Laryngoscope 109: 324–328
Clarke JD, Eccles R (2005) Paradoxical sensation of nasal airflow in patients with common cold. Are we measuring the correct modality? Acta Otolaryngol 125: 1307–1311
Feldman PJ, Cohen S, Doyle WJ, Skoner DP, Gwaltney JM, Jr. (1999) The impact of personality on the reporting of unfounded symptoms and illness. J Pers Soc Psychol 77: 370–378
Cohen S, Alper CM, Doyle WJ, Treanor JJ, Turner RB (2006) Positive emotional style predicts resistance to illness after experimental exposure to rhinovirus or influenza a virus. Psychosom Med 68: 809–815
Naclerio RM, Proud D, Kagey-Sobotka A, Lichtenstein LM, Hendley JO, Gwaltney JM Jr (1988) Is histamine responsible for the symptoms of rhinovirus colds? A look at the inflammatory mediators following infection. Pediatr Infect Dis J 7: 218–222
Cohen S, Doyle WJ, Skoner DP, Rabin BS, Gwaltney JM, Jr. (1997) Social ties and susceptibility to the common cold. JAMA 277: 1940–1944
Bousquet J, Vignola AM, Campbell AM, Michel FB (1996) Pathophysiology of allergic rhinitis. Int Arch Allergy Immunol 110: 207–218
Doyle WJ, Skoner DP, Seroky JT, Fireman P, Gwaltney JM (1994) Effect of experimental rhinovirus 39 infection on the nasal response to histamine and cold air challenges in allergic and nonallergic subjects. J Allergy Clin Immunol 93: 534–542
Ko FW, Lai CK, Woo J, Ho SC, Ho CW, Goggins W, Hui DS (2006) 12-year change in prevalence of respiratory symptoms in elderly Chinese living in Hong Kong. Respir Med 100: 1598–1607
Koskinen OM, Husman TM, Meklin TM, Nevalainen AI (1999) The relationship between moisture or mould observations in houses and the state of health of their occupants. Eur Respir J 14: 1363–1367
Doyle WJ, Skoner DP, Gentile D (2005) Nasal cytokines as mediators of illness during the common cold. Curr Allergy Asthma Rep 5: 173–181
Eccles R (1995) Rhinitis as a mechanism of respiratory defense. Eur Arch Otorhinolaryngol 252 (Suppl 1): S2–7
Eccles R (1996) A role for the nasal cycle in respiratory defence. Eur Respir J 9: 371–376
Bazar KA, Yun AJ, Lee PY (2005) “Starve a fever and feed a cold”: feeding and anorexia may be adaptive behavioral modulators of autonomic and T helper balance. Med Hypotheses 64: 1080–1084
Mygind N (2001) Nasal inflammation and anti-inflammatory treatment. Semantics or clinical reality. Rhinology 39: 61–65
Gwaltney JM (2002) Viral respiratory infection therapy: historical perspectives and current trials. Am J Med 112 (Suppl) 6A: 33S–41S
Eccles R (2006) Efficacy and safety of over-the-counter analgesics in the treatment of common cold and flu. J Clin Pharm Ther 31: 309–319
Cohen S, Tyrrell DA, Smith AP (1991) Psychological stress and susceptibility to the common cold. N Engl J Med 325: 606–612
Badger GF, Dingle JH, Feller AE, Hodges RG, Jordan WS, Jr., Rammelkamp CH, Jr. (1953) A study of illness in a group of Cleveland families. II. Incidence of the common respiratory diseases. Am J Hyg 58: 31–40
Gwaltney JM, Jr., Hendley JO, Simon G, Jordan WS, Jr. (1966) Rhinovirus infections in an industrial population. I. The occurrence of illness. N Engl J Med 275: 1261–1268
Spigland I, Fox JP, Elveback LR, Wassermann FE, Ketler A, Brandt CD, Kogon A (1966) The Virus Watch program: a continuing surveillance of viral infections in metropolitan New York families. II. Laboratory methods and preliminary report on infections revealed by virus isolation. Am J Epidemiol 83: 413–435
Monto AS, Cavallaro JJ, Keller JB (1970) Seasonal patterns of acute infection in Tecumseh, Mich. Arch Environ Health 21: 408–417
Monto AS, Cavallaro JJ (1971) The Tecumseh study of respiratory illness. II. Patterns of occurrence of infection with respiratory pathogens, 1965–1969. Am J Epidemiol 94: 280–289
Monto AS, Koopman JS, Bryan ER (1986) The Tecumseh Study of Illness. XIV. Occurrence of respiratory viruses, 1976–1981. Am J Epidemiol 124: 359–367
Monto AS (2002) The seasonality of rhinovirus infections and its implications for clinical recognition. Clin Ther 24: 1987–1997
Monto AS (2002) Epidemiology of viral respiratory infections. Am J Med 112 (Suppl) 6A:4S–12S
Chew FT, Doraisingham S, Ling AE, Kumarasinghe G, Lee BW (1998) Seasonal trends of viral respiratory tract infections in the tropics. Epidemiol Infect 121: 121–128
Shek LP, Lee BW (2003) Epidemiology and seasonality of respiratory tract virus infections in the tropics. Paediatr Respir Rev 4:105–111
Moura FE, Nunes IF, Silva GB, Jr., Siqueira MM (2006) Respiratory syncytial virus infections in northeastern Brazil: seasonal trends and genral aspects. Am J Trop Med Hyg 74:165–167
Nelson MI, Simonsen L, Viboud C, Miller MA, Holmes EC (2007) Phylogenetic analysis reveals the global migration of seasonal influenza A viruses. PLoS Pathog 3: 1220–1228
Weber A, Weber M, Milligan P (2001) Modeling epidemics caused by respiratory syncytial virus (RSV). Math Biosci 172:95–113
White LJ, Mandl JN, Gomes MG, Bodley-Tickell AT, Cane PA, Perez-Brena P, Aguilar JC, Siqueira MM, Portes SA, Straliotto SM et al. (2007) Understanding the transmission dynamics of respiratory syncytial virus using multiple time series and nested models. Math Biosci 209:222–239
Welliver RC, Sr. (2007) Temperature, humidity, and ultraviolet B radiation predict community respiratory syncytial virus activity. Pediatr Infect Dis J 26: S29–35
Viboud C, Pakdaman K, Boelle PY, Wilson ML, Myers MF, Valleron AJ, Flahault A (2004) Association of influenza epidemics with global climate variability. Eur J Epidemiol 19:1055–1059
Alonso WJ, Viboud C, Simonsen L, Hirano EW, Daufenbach LZ, Miller MA (2007) Seasonality of influenza in Brazil: a traveling wave from the Amazon to the subtropics. Am J Epidemiol 165:1434–1442
Noyola DE, Mandeville PB (2008) Effect of climatological factors on respiratory syncytial virus epidemics. Epidemiol Infect: 1–6
Oliveira AC, Ishimaru D, Goncalves RB, Smith TJ, Mason P, Sa-Carvalho D, Silva JL (1999) Low temperature and pressure stability of picornaviruses: implications for virus uncoating. Biophys J 76:1270–1279
Ausar SF, Rexroad J, Frolov VG, Look JL, Konar N, Middaugh CR (2005) Analysis of the thermal and pH stability of human respiratory syncytial virus. Mol Pharm 2:491–499
Polozov IV, Bezrukov L, Gawrisch K, Zimmerberg J (2008) Progressive ordering with decreasing temperature of the phospholipids of influenza virus. Nat Chem Biol 4:248–255
Light M (2007) Respiratory syncytial virus seasonality in southeast Florida: results from three area hospitals caring for children. Pediatr Infect Dis J 26: S55–59
Tang JW, Ngai KL, Lam WY, Chan PK (2008) Seasonality of influenza A (H3N2) virus: a Hong Kong perspective (1997-2006). PLoS ONE 3:e2768
Wong S, Pabbaraju K, Pang XL, Lee BE, Fox JD (2008) Detection of a broad range of human adenoviruses in respiratory tract samples using a sensitive multiplex real-time PCR assay. J Med Virol 80:856–865
Greene SK, Ionides EL, Wilson ML (2006) Patterns of influenza-associated mortality among US elderly by geographic region and virus subtype, 1968-1998. Am J Epidemiol 163:316–326
Bang FB, Bang MG, Bang BG (1975) Ecology of respiratory virus transmission: a comparison of three communities in West Bengal. Am J Trop Med Hyg 24: 326–346
Monto AS (1968) A community study of respiratory infections in the tropics. 3. Introduction and transmission of infections within families. Am J Epidemiol 88: 69–79
Monto AS, Sullivan KM (1993) Acute respiratory illness in the community. Frequency of illness and the agents involved. Epidemiol Infect 110:145–160
Wald ER, Dashefsky B, Byers C, Guerra N, Taylor F (1988) Frequency and severity of infections in day care. J Pediatr 112:540–546
Benediktsdottir B (1993) Upper airway infections in preschool children — frequency and risk factors. Scand J Prim Health Care 11:197–201
Ball TM, Holberg CJ, Aldous MB, Martinez FD, Wright AL (2002) Influence of attendance at day care on the common cold from birth through 13 years of age. Arch Pediatr Adolesc Med 156:121–126
Zutavern A, Rzehak P, Brockow I, Schaaf B, Bollrath C, von Berg A, Link E, Kraemer U, Borte M, Herbarth O et al. (2007) Day care in relation to respiratory-tract and gastrointestinal infections in a German birth cohort study. Acta Paediatr 96:1494–1499
Jaakkola JJ, Heinonen OP (1995) Shared office space and the risk of the common cold. Eur J Epidemiol 11:213–216
Wright SA, Bieluch VM (1993) Selected nosocomial viral infections. Heart Lung 22:183–187
Mlinaric-Galinovic G, Varda-Brkic D (2000) Nosocomial respiratory syncytial virus infections in children’s wards. Diagn Microbiol Infect Dis 37:237–246
Aitken C, Jeffries DJ (2001) Nosocomial spread of viral disease. Clin Microbiol Rev 14:528–546
Montnemery P, Popovic M, Andersson M, Greiff L, Nyberg P, Lofdahl CG, Svensson C, Persson CG (2003) Influence of heavy traffic, city dwelling and socio-economic status on nasal symptoms assessed in a postal population survey. Respir Med 97:970–977
Thompson DJ, Lebowitz M, Cassell EJ, Wolter D, McCarroll J (1970) Health and the urban environment. 8. Air pollution, wealther, and the common cold. Am J Public Health Nations Heath 60:731–739
Jaakkola JJ, Paunio M, Virtanen M, Heinonen OP (1991) Low-level air pollution and upper respiratory infections in children. Am J Public Health 81: 1060–1063
Bayer-Oglesby L, Grize L, Gassner M, Takken-Sahli K, Sennhauser FH, Neu U, Schindler C, Braun-Fahrlander C (2005) Decline of ambient air pollution levels and improved respiratory health in Swiss children. Environ Health Perspect 113:1632–1637
Jaakkola JJ, Partti-Pellinen K, Marttila O, Miettinen P, Vilkka V, Haahtela T (1999) The South Karelia Air Pollution Study: changes in respiratory health in relation to emission reduction of malodorous sulfur compounds from pulp mills. Arch Environ Health 54:254–263
Kumar R, Nagar JK, Kumar H, Kushwah AS, Meena M, Kumar P, Raj N, Singhal MK, Gaur SN (2007) Association of indoor and outdoor air pollutant level with respiratory problems among children in an industrial area of Delhi, India. Arch Environ Occup Health 62:75–80
Pirhonen I, Nevalainen A, Husman T, Pekkanen J (1996) Home dampness, moulds and their influence on respiratory infections and symptoms in adults in Finland. Eur Respir J 9:2618–2622
Selye H (1976) Forty years of stress research: principal remaining problems and misconceptions. Can Med Assoc J 115:53–56
Cohen S, Miller GE, Rabin BS (2001) Psychological stress and antibody response to immunization: a critical review of the human literature. Psychosom Med 63:7–18
Webster Marketon JI, Glaser R (2008) Stres hormones and immune function. Cell Immunol 252:16–26
Cohen S, Williamson GM (1991) Stress and infectious disease in humans. Psychol Bull 109:5–24
Cohen S, Doyle WJ, Baum A (2006) Socioeconomic status is associated with stress hormones. Psychosom Med 68:414–420
Cohen S, Doyle WJ, Turner RB, Alper CM, Skoner DP (2004) Childhood socioeconomic status and host resistance to infectious illness in adulthood. Psychosom Med 66:553–558
Angeli A, Minetto M, Dovio A, Paccotti P (2004) The overtraining syndrome in athletes: a stress-related disorder. J Endocrinol Invest 27:603–612
Nieman DC (2003) Current perspective on exercise immunology. Curr Sports Med Rep 2:239–242
Mohren DC, Swaen GM, Borm PJ, Bast A, Galama JM (2001) Psychological job demands as a risk factor for common cold in a Dutch working population. J Psychosom Res 50:21–27
Mohren DC, Jansen NW, Kant IJ, Galama J, van den Brandt PA, Swaen GM (2002) Prevalence of common infections among employees in different work schedules. J Occup Environ Med 44:1003–1011
Mohren DC, Swaen GM, Kant IJ, van Amelsvoort LG, Borm PJ, Galama JM (2003) Common infections and the role of burnout in a Dutch working population. J Psychosom Res 55:201–208
Koh D, Yong Y, Ng V, Chia SE (2002) Stress, mucosal immunity, upper respiratory tract infections, and sickness absence. J Occup Environ Med 44:987–988
Cohen S (2005) Keynote Presentation at the Eight International Congress of Behavioral Medicine: the Pittsburgh common cold studies: psychosocial predictors of susceptibility to respiratory infectious illness. Int J Behav Med 12: 123–131
Tache J, Selye H (1985) On stress and coping mechanisms. Issues Ment Health Nurs 7:3–24
Boyce WT, Jensen EW, Cassel JC, Collier AM, Smith AH, Ramey CT (1977) Influence of life events and family routines on childhood respiratory tract illness. Pediatrics 60:609–615
Totman R, Kiff J, Reed SE, Craig JW (1980) Predicting experimental colds in volunteers from different measures of recent life stress. J Psychosom Res 24: 155–163
Cohen S, Doyle WJ, Skoner DP (1999) Psychological stress, cytokine production, and severity of upper respiratory illness. Psychosom Med 61:175–180
Spilken AZ, Jacobs MA (1971) Prediction of illness behavior from measures of life crisis, manifest distress and maladaptive coping. Psychosom Med 33: 251–264
Graham NM, Douglas RM, Ryan P (1986) Stress and acute respiratory infection. Am J Epidemiol 124:389–401
Smith A, Nicholson K (2001) Psychosocial factors, respiratory viruses and exacerbation of asthma. Psychoneuroendocrinology 26:411–420
Stone AA, Reed BR, Neale JM (1987) Changes in daily event frequency precede episodes of physical symptoms. J Human Stress 13:70–74
Evans PD, Edgerton N (1991) Life-events and mood as predictors of the common cold. Br J Med Psychol 64 (Pt 1):35–44
Takkouche B, Regueira C, Gestal-Otero JJ (2001) A cohort study of stress and the common cold. Epidemiology 12:345–349
Cobb JM, Steptoe A (1996) Psychosocial stress and susceptibility to upper respiratory tract illness in an adult population sample. Psychosom Med 58: 404–412
Turner Cobb JM, Steptoe A (1998) Psychosocial influences on upper respiratory infectious illness in children. J Psychosom Res 45:319–330
Cohen S, Tyrrell DA, Smith AP (1993) Negative life events, perceived stress, negative affect, and susceptibility to the common cold. J Pers Soc Psychol 64: 131–140
Stone AA, Bovbjerg DH, Neale JM, Napoli A, Valdimarsdottir H, Cox D, Hayden FG, Gwaltney JM Jr (1992) Development of common cold symptoms following experimental rhinovirus infection is related to prior stressful life events. Behav Med 18:115–120
Cohen S, Hamrick N, Rodriguez MS, Feldman PJ, Rabin BS, Manuck SB (2002) Reactivity and vulnerability to stress-associated risk for upper respiratory illness. Psychosom Med 64:302–310
Boyce WT, Chesterman EA, Martin N, Folkman S, Cohen F, Wara D (1993) Immunologic changes occurring at kindergarten entry predict respiratory illnesses after the Loma Prieta earthquake. J Dev Behav Pediatr 14:296–303
Boyce WT, Chesney M, Alkon A, Tschann JM, Adams S, Chesterman B, Cohen F, Kaiser P, Folkman S, Wara D (1995) Psychobiologic reactivity to stress and childhood respiratory illnesses: results of two prospective studies. Psychosom Med 57:411–422
Cobb S (1976) Presidential Address-1976. Social support as a moderator of life stress. Psychosom Med 38:300–314
House JS, Landis KR, Umberson D (1988) Social relationships and health. Science 241:540–545
Uchino BN, Cacioppo JT, Kiecolt-Glaser JK (1996) The relationship between social support and physiological processes: a review with emphasis on underlying mechanisms and implications for health. Psychol Bull 119:488–531
Cohen S (2004) Social relationships and health. Am Psychol 59:676–684
Pressman SD, Cohen S, Miller GE, Barkin A, Rabin BS, Treanor JJ (2005) Loneliness, social network size, and immune response to influenza vaccination in college freshmen. Health Psychol 24:297–306
Monto AS, Ullman BM (1974) Acute respiratory illness in an American community. The Tecumseh study. JAMA 227:164–169
Cohen S, Doyle WJ, Turner R, Alper CM, Skoner DP (2003) Sociability and susceptibility to the common cold. Psychol Sci 14:389–395
Cohen S, Alper CM, Doyle WJ, Adler N, Treanor JJ, Turner RB (2008) Objective and subjective socioeconomic status and susceptibility to the common cold. Health Psychol 27:268–274
Benson V, Marano MA (1998) Current estimates from the National Health Interview Survey, 1995. Vital Health Stat 10:1–428
Adler NE, Boyce T, Chesney MA, Cohen S, Folkman S, Kahn RL, Syme SL (1994) Socioeconomic status and health. The challenge of the gradient. Am Psychol 49:15–24
Anderson NB, Armstead CA (1995) Toward understanding the association of socioeconomic status and health: a new challenge for the biopsychosocial approach. Psychosom Med 57:213–225
Naess O, Claussen B, Thelle DS, Smith GD (2005) Four indicators of socioeconomic position: relative ranking across causes of death. Scand J Public Health 33:215–221
Alper CM, Winther B, Mandel EM, Doyle WJ (2007) Temporal relationships for cold-like illnesses and otitis media in sibling pairs. Pediatr Infect Dis J 26: 778–781
Galobardes B, Lynch JW, Smith GD (2008) Is the association between childhood socioeconomic circumstances and cause-specific mortality established? Update of a systematic review. J Epidemiol Community Health 62:387–390
Kaushik PV, Singh JV, Bhatnagar M, Garg SK, Chopra H (1995) Nutritional correlates of acute respiratory infections. Indian J Matern Child Health 6: 71–72
Alaimo K, Olson CM, Frongillo EA, Jr., Briefel RR (2001) Food insufficiency, family income, and health in US preschool and school-aged children. Am J Public Health 91:781–786
Takkouche B, Regueira-Mendez C, Garcia-Closas R, Figueiras A, Gestal-Otero JJ (2002) Intake of vitamin C and zinc and risk of common cold: a cohort study. Epidemiology 13:38–44
Hemila H, Kaprio J, Albanes D, Heinonen OP, Virtamo J (2002) Vitamin C, vitamin E, and beta-carotene in relation to common cold incidence in male smokers. Epidemiology 13:32–37
Roxas M, Jurenka J (2007) Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations. Altern Med Rev 12:25–48
Ballabh B, Chaurasia OP (2007) Traditional medicinal plants of cold desert Ladakh — used in treatment of cold, cough and fever. J Ethnopharmacol 112: 341–349
Douglas RM, Hemila H, Chalker E, Treacy B (2007) Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev: CD000980
Fischer Walker C, Black RE (2004) Zinc and the risk for infectious disease. Annu Rev Nutr 24:255–275
Turner RB, Bauer R, Woelkart K, Hulsey TC, Gangemi JD (2005) An evaluation of Echinacea angustifolia in experimental rhinovirus infections. N Engl J Med 353:341–348
Meydani SN, Han SN, Hamer DH (2004) Vitamin E and respiratory infection in the elderly. Ann NY Acad Sci 1031:214–222
Hemila H (1996) Vitamin C and common cold incidence: a review of studies with subjects under heavy physical stress. Int J Sports Med 17:379–383
Hemila H, Douglas RM (1999) Vitamin C and acute respiratory infections. Int J Tuberc Lung Dis 3:756–761
Winkler P, de Vrese M, Laue C, Schrezenmeir J (2005) Effect of a dietary supplement containing probiotic bacteria plus vitamins and minerals on common cold infections and cellular immune parameters. Int J Clin Pharmacol Ther 43: 318–326
Rowe CA, Nantz MP, Bukowski JF, Percival SS (2007) Specific formulation of Camellia sinensis prevents cold and flu symptoms and enhances gamma, delta T cell function: a randomized, double-blind, placebo-controlled study. J Am Coll Nutr 26:445–452
Sarma KV, Udaykumar P, Balakrishna N, Vijayaraghavan K, Sivakumar B (2006) Effect of micronutrient supplementation on health and nutritional status of schoolchildren: growth and morbidity. Nutrition 22:S8–14
Maeda H, Ichihashi K, Fujii T, Omura K, Zhu X, Anazawa M, Tazawa K (2004) Oral administration of hydrolyzed rice bran prevents the common cold syndrome in the elderly based on its immunomodulatory action. Biofactors 21: 185–187
Sopori ML, Kozak W (1998) Immunomodulatory effects of cigarette smoke. J Neuroimmunol 83:148–156
McAllister-Sistilli CG, Caggiula AR, Knopf S, Rose CA, Miller AL, Donny EC (1998) The effects of nicotine on the immune system. Psychoneuroendocrinology 23:175–187
Diaz LE, Montero A, Gonzalez-Gross M, Vallejo AI, Romeo J, Marcos A (2002) Influence of alcohol consumption on immunological status: a review. Eur J Clin Nutr 56 (Suppl) 3: S50–53
Romeo J, Warnberg J, Nova E, Diaz LE, Gomez-Martinez S, Marcos A (2007) Moderate alcohol consumption and the immune system: a review. Br J Nutr 98 (Suppl 1):S111–115
Atkinson JP, Sullivan TJ, Kelly JP, Parker CW (1977) Stimulation by alcohols of cyclic AMP metabolism in human leukocytes. Possible role of cyclic AMP in the anti-inflammatory effects of ethanol. J Clin Invest 60:284–294
Lister SM, Jorm LR (1998) Parental smoking and respiratory illnesses in Australian children aged 0-4 years: ABS 1989-90 National Health Survey results Aust NZ J Public Health 22:781–786
Bensenor IM, Cook NR, Lee IM, Chown MJ, Hennekens CH, Buring JE, Manson JE (2001) Active and passive smoking and risk of colds in women. Ann Epidemiol 11:225–231
Finklea JE, Sandifer SH, Smith DD (1969) Cigarette smoking and epidemic influenza. Am J Epidemiol 90:390–399
MacKenzie JS, MacKenzie IH, Holt PG (1976) The effect of cigarette smoking on susceptibility to epidemic influenza and on serological responses to live attenuated and killed subunit influenza vaccines. J Hyg (Lond) 77:409–417
Monto AS, Ross H (1977) Acute respiratory illness in the community: effect of family composition, smoking, and chronic symptoms. Br J Prev Soc Med 31:101–108
Takkouche B, Regueira-Mendez C, Garcia-Closas R, Figueiras A, Gestal-Otero JJ, Hernan MA (2002) Intake of wine, beer, and spirits and the risk of clinical common cold. Am J Epidemiol 155:853–858
Cohen S, Tyrrell DA, Russell MA, Jarvis MJ, Smith AP (1993) Smoking, alcohol consumption, and susceptibility to the common cold. Am J Public Health 83:1277–1283
Moldoveanu AI, Shephard RJ, Shek PN (2001) The cytokine response to physical activity and training. Sports Med 31:115–144
Gleeson M (2007) Immune function in sport and exercise. J Appl Physiol 103:693–699
Brolinson PG, Elliott D (2007) Exercise and the immune system. Clin Sports Med 26:311–319
Pedersen BK, Toft AD (2000) Effects of exercise on lymphocytes and cytokines. Br J Sports Med 34:246–251
Malm C (2006) Susceptibility to infections in elite athletes: the S-curve. Scand J Med Sci Sports 16:4–6
Spence L, Brown WJ, Pyne DB, Nissen MD, Sloots TP, McCormack JG, Locke AS, Fricker PA (2007) Incidence, etiology, and symptomatology of upper respiratory illness in elite athletes. Med Sci Sports Exerc 39:577–586
Osterback L, Qvarnberg Y (1987) A prospective study of respiratory infections in 12-year-old children actively engaged in sports. Acta Paediatr Scand 76:944–949
Weidner TG, Cranston T, Schurr T, Kaminsky LA (1998) The effect of exercise training on the severity and duration of a viral upper respiratory illness. Med Sci Sports Exerc 30:1578–1583
Kostka T, Berthouze SE, Lacour J, Bonnefoy M (2000) The symptomatology of upper respiratory tract infections and exercise in elderly people. Med Sci Sports Exerc 32:46–51
Chubak J, McTiernan A, Sorensen B, Wener MH, Yasui Y, Velasquez M, Wood B, Rajan KB, Wetmore CM, Potter JD et al. (2006) Moderate-intensity exercise reduces the incidence of colds among postmenopausal women. Am J Med 119:937–942
Irwin M, McClintick J, Costlow C, Fortner M, White J, Gillin JC (1996) Partial night sleep deprivation reduces natural killer and cellular immune responses in humans. Faseb J 10:643–653
Vgontzas AN, Zoumakis E, Bixler EO, Lin HM, Follett H, Kales A, Chrousos GP (2004) Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines. J Clin Endocrinol Metab 89:2119–2126
Lange T, Perras B, Fehm HL, Born J (2003) Sleep enhances the human antibody response to hepatitis A vaccination. Psychosom Med 65:831–835
Spiegel K, Sheridan JF, Van Cauter E (2002) Effect of sleep deprivation on response to immunization. JAMA 288:1471–1472
Cohen S, Doyle WJ, Alper CM, Janicki-Deverts D, Turner RB (2009) Sleep habits and susceptibility to the common cold. Arch Intern Med 169:62–67
Gwaltney JM Jr (1985) Virology and immunology of the common cold. Rhinology 23:265–271
Reuman PD, Ayoub EM, Small PA (1987) Effect of passive maternal antibody on influenza illness in children: a prospective study of influenza A in mother-infant pairs. Pediatr Infect Dis J 6:398–403
Falsey AR (2007) Respiratory syncytial virus infection in adults. Semin Respir Crit Care Med 28:171–181
Renegar KB, Small PA Jr (1991) Passive transfer of local immunity to influenza virus infection by IgA antibody. J Immunol 146:1972–1978
Murphy BR, Graham BS, Prince GA, Walsh EE, Chanock RM, Karzon DT, Wright PF (1986) Serum and nasal-wash immunoglobulin G and A antibody response of infants and children to respiratory syncytial virus F and G glyco-proteins following primary infection. J Clin Microbiol 23:1009–1014
Greenbaum E, Furst A, Kiderman A, Stewart B, Levy R, Schlesinger M, Morag A, Zakay-Rones Z (2001) Serum and mucosal immunologic responses in children following the administration of a new inactivated intranasal anti-influenza vaccine. J Med Virol 65:178–184
Brandtzaeg P (2003) Role of mucosal immunity in influenza. Dev Biol (Basel) 115:39–48
Alper CM, Doyle WJ, Skoner DP, Buchman CA, Cohen S, Gwaltney JM (1998) Prechallenge antibodies moderate disease expression in adults experimentally exposed to rhinovirus strain hanks. Clin Infect Dis 27:119–128
Alper CM, Doyle WJ, Skoner DP, Buchman CA, Seroky JT, Gwaltney JM, Cohen SA (1996) Prechallenge antibodies: moderators of infection rate, signs, and symptoms in adults experimentally challenged with rhinovirus type 39. Laryngoscope 106:1298–1305
Gafafer WM, Doull JA (1933) A note on the stability of resistance to colds. Science 78:314–315
Wilson EB, Worcester J (1944) Note on stability of incidence of the “Common Cold”. Science 99:468–469
Ball TM, Holberg CJ, Martinez FD, Wright AL (2002) Is there a common cold constitution? Ambul Pediatr 2:261–267
Doyle WJ, Winther B, Alper CM (2008) Daily tympanometry for high-resolution measurement of the time between onset of cold-like illness and middle ear effusion. Laryngoscope 118:1066–1071
Cedzynski M, Szemraj J, Swierzko AS, Bak-Romaniszyn L, Banasik M, Zeman K, Kilpatrick DC (2004) Mannan-binding lectin insufficiency in children with recurrent infections of the respiratory system. Clin Exp Immunol 136:304–311
Heine H, Lien E (2003) Toll-like receptors and their function in innate and adaptive immunity. Int Arch Allergy Immunol 130:180–192
Tamura S, Kurata T (2004) Defense mechanisms against influenza virus infection in the respiratory tract mucosa. Jpn J Infect Dis 57:236–247
Message SD, Johnston SL (2004) Host defense function of the airway epithelium in health and disease: clinical background. J Leukoc Biol 75:5–17
Isaacs D, Clarke JR, Tyrrell DA, Webster AD, Valman HB (1981) Deficient production of leucocyte interferon (interferon-alpha) in vitro and in vivo in children with recurrent respiratory tract infections. Lancet 2:950–952
Pitkaranta A, Karma P, Hovi T (1993) Deficiency in interferon production by leukocytes from children with recurrent respiratory infections. Clin Diagn Virol 1:101–108
Pitkaranta A, Nokso-Koivisto J, Jantti V, Takala A, Kilpi T, Hovi T (1999) Lowered yields of virus-induced interferon production in leukocyte cultures and risk of recurrent respiratory infections in children. J Clin Virol 14:199–205
Bella J, Rossmann MG (2000) ICAM-1 receptors and cold viruses. Pharm Acta Helv 74:291–297
Becker N, Abel U, Stiepak C, Meuer SC (1992) Frequency of common colds and serum levels of sICAM-1 (CD54), sLFA-3 (CD58) and sIL-2R (CD25). Eur Cytokine Netw 3:545–551
Infante-Duarte C, Kamradt T (1999) Th1/Th2 balance in infection. Springer Semin Immunopatho 21:317–338
Skoner DP, Doyle WJ, Tanner EP, Kiss J, Fireman P (1995) Effect of rhinovirus 39 (RV-39) infection on immune and inflammatory parameters in allergic and non-allergic subjects. Clin Exp Allergy 25:561–567
Gentile DA, Doyle WJ, Fireman P, Skoner DP (2001) Effect of experimental influenza A infection on systemic immune and inflammatory parameters in allergic and nonallergic adult subjects. Ann Allergy Asthma Immunol 87:496–500
Fleming HE, Little FF, Schnurr D, Avila PC, Wong H, Liu J, Yagi S, Boushey HA (1999) Rhinovirus — 16 colds in healthy and in asthmatic subjects: similar changes in upper and lower airways. Am J Respir Crit Care Med 160:100–108
Avila PC, Abisheganaden JA, Wong H, Liu J, Yagi S, Schnurr D, Kishiyama JL, Boushey HA (2000) Effects of allergic inflammation of the nasal mucosa on the severity of rhinovirus 16 cold. J Allergy Clin Immunol 105:923–932
Corne JM, Marshall C, Smith S, Schreiber J, Sanderson G, Holgate ST, Johnston SL (2002) Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study. Lancet 359:831–834
Kimman TG, Vandebriel RJ, Hoebee B (2007) Genetic variation in the response to vaccination. Community Genet 10:201–217
Singh N, Agrawal S, Rastogi AK (1997) Infectious diseases and immunity: special reference to major hostocompatibility complex. Emerg Infect Dis 3:41–49
Nieters A, Brems S, Becker N (2001) Cross-sectional study on cytokine polymorphisms, cytokine production after T-cell stimulation and clinical parameters in a random sample of a German population. Hum Genet 108:241–248
Sumiya M, Summerfield JA (1997) The role of collectins in host defense. Semin Liver Dis 17:311–318
Ruskamp JM, Hoekstra MO, Rovers MM, Schilder AG, Sanders EA (2006) Mannose-binding lectin and upper respiratory tract infections in children and adolescents: a review. Arch Otolaryngol Head Neck Surg 132:482–486
Koch A, Melbye M, Sorensen P, Homoe P, Madsen HO, Molbak K, Hansen CH, Andersen LH, Hahn GW, Garred P (2001) Acute respiratory tract infections and mannose-binding lectin insufficiency during early childhood. JAMA 285:1316–1321
Woo P (2000) Cytokine polymorphisms and inflammation. Clin Exp Rheumatol 18:767–771
Gentile DA, Doyle WJ, Zeevi A, Piltcher O, Skoner DP (2003) Cytokine gene polymorphisms moderate responses to respiratory syncytial virus in adults. Hum Immunol 64:93–98
Doyle WJ, Gentile DA, Cohen S (2006) Emotional style, nasal cytokines, and illness expression after experimental rhinovirus exposure. Brain Behav Immun 20:175–181
Gentile DA, Doyle WJ, Zeevi A, Howe-Adams J, Kapadia S, Trecki J, Skoner DP (2003) Cytokine gene polymorphisms moderate illness severity in infants with respiratory syncytial virus infection. Hum Immunol 64:338–344
Alper CM, Winther B, Owen Hendley J, Doyle WJ (2008) Cytokine polymorphisms predict the frequency of otitis media as a complication of rhinovirus and RSV infections in children. Eur Arch Otorhinolaryngol 266:199–205
Miller GE, Cohen S, Rabin BS, Skoner DP, Doyle WJ (1999) Personality and tonic cardiovascular, neuroendocrine, and immune parameters. Brain Behav Immun 13:109–123
Jang KL, Livesley WJ, Vernon PA (1996) Heritability of the big five personality dimensions and their facets: a twin study. J Pers 65:577–591
Bratko D, Butkovic A (2007) Stability of genetic and environmental effects from adolescence to young adulthood: results of Croatian longitudinal twin study of personality. Twin Res Hum Genet 10:151–157
Hampson SE, Goldberg LR (2006) A first large cohort study of personality trait stability over the 40 years between elementary school and midlife. J Pers Soc Psychol 91:763–779
Broadbent DE, Broadbent MH, Phillpotts RJ, Wallace J (1984) Some further studies on the prediction of experimental colds in volunteers by psychological factors. J Psychosom Res 28:511–523
Cohen S, Doyle WJ, Skoner DP, Fireman P, Gwaltney JM, Jr., Newsom JT (1995) State and trait negative affect as predictors of objective and subjective symptoms of respiratory viral infections. J Pers Soc Psychol 68:159–169
Cohen S, Doyle WJ, Turner RB, Alper CM, Skoner DP (2003) Emotional style and susceptibility to the common cold. Psychosom Med 65:652–657
Stone AA, Cox DS, Valdimarsdottir H, Jandorf L, Neale JM (1987) Evidence that secretory IgA antibody is associated with daily mood. J Pers Soc Psychol 52:988–993
Hall S, Smith A (1996) Investigation of the effects and aftereffects of naturally occurring upper respiratory tract illnesses on mood and performance. Physiol Behav 59:569–577
Smith A, Thomas M, Kent J, Nicholson K (1998) Effects of the common cold on mood and performance. Psychoneuroendocrinology 23:733–739
Smith A, Thomas M, Whitney H (2000) Effects of upper respiratory tract illnesses on mood and performance over the working day. Ergonomics 43:752–763
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Doyle, W.J., Cohen, S. (2009). Etiology of the common cold: Modulating factors. In: Eccles, R., Weber, O. (eds) Common Cold. Birkhäuser Advances in Infectious Diseases. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-9912-2_6
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