Summary
A selective, quantitative and high resolution technique (in vitro and in vivo enzyme radioautography) has been used to reveal the tissue distribution and abundance of MAO-A and MAO-B in the central nervous system and peripheral organs in the rat. The in vitro approach was also used to map the enzymes in human post-mortem brain. Furthermore, using in situ hybridization histochemistry, locus coeruleus and raphé neurons in the human brain were found to code for MAO-A and MAO-B respectively and not vice versa.
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References
Da Prada M, Kettler R, Keller HH, Cesura AM, Richards JG, Saura Marti J, Muggli-Maniglio D, Wyss P-C, Kyburz E, Imhof R (1990) From moclobemide to Ro 19-6327 and Ro 41-1049: the development of a new class of reversible, selective MAO-A and MAO-B inhibitors. J Neural Transm [Suppl] 29:179–192.
Saura Marti J, Kettler R, Da Prada M, Richards JG (1991) Localization of MAO-A and MAO-B in rat CNS, peripheral organs and human brain: quantitative enzyme radioautography of [3H]Ro 41-1049 and [3H]Ro 19-6327. (Submitted).
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© 1990 Springer-Verlag
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Saura Marti, J., Kettler, R., Da Prada, M., Richards, J.G. (1990). Molecular neuroanatomy of MAO-A and MAO-B. In: Riederer, P., Youdim, M.B.H. (eds) Amine Oxidases and Their Impact on Neurobiology. Journal of Neural Transmission, vol 32. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9113-2_5
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DOI: https://doi.org/10.1007/978-3-7091-9113-2_5
Publisher Name: Springer, Vienna
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