Abstract
Gustation is a multisensory process allowing for the selection of nutrients and the rejection of irritating and/or toxic compounds. Since obesity is a highly prevalent condition that is critically dependent on food intake and energy expenditure, a deeper understanding of gustatory processing is an important objective in biomedical research. Recent findings have provided evidence that central gustatory processes are distributed across several cortical and subcortical brain areas. Furthermore, these gustatory sensory circuits are closely related to the circuits that process reward. Here, we present an overview of the activation and connectivity between central gustatory and reward areas. Moreover, and given the limitations in number and effectiveness of treatments currently available for overweight patients, we discuss the possibility of modulating neuronal activity in these circuits as an alternative in the treatment of obesity.
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Abbott CR, Monteiro M, et al. (2005) The inhibitory effects of peripheral administration of peptide YY(3–36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway. Brain Res 1044(1): 127–31
Abizaid A, Liu ZW, et al. (2006) Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J Clin Invest 116(12): 3229–39
Accolla R, Bathellier B, et al. (2007) Differential spatial representation of taste modalities in the rat gustatory cortex. J Neurosci 27(6): 1396–404
Altschuler SM, Bao XM, et al. (1989) Viscerotopic representation of the upper alimentary tract in the rat: sensory ganglia and nuclei of the solitary and spinal trigeminal tracts. J Comp Neurol 283(2): 248–68
Anand BK, Brobeck JR (1951) Localization of a “feeding center in the hypothalamus of the rat. Proc Soc Exp Biol Med 77(2): 323–24
Andrews ZB, Horvath TL (2008) Tasteless food reward. Neuron 57(6): 806–08
Ashrafian H, le Roux CW (2009) Metabolic surgery and gut hormones — a review of bariatric entero-humoral modulation. Physiol Behav 97(5): 620–31
Baldo BA, Daniel RA, et al. (2003) Overlapping distributions of orexin/hypocretin-and dopamine-beta-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress. J Comp Neurol 464(2): 220–37
Banks WA, Kastin AJ, et al. (1995) Regional variation in transport of pancreatic polypeptide across the blood-brain barrier of mice. Pharmacol Biochem Behav 51(1): 139–47
Bartel DL, Sullivan SL, et al. (2006) Nucleoside triphosphate diphosphohydrolase-2 is the ecto-ATPase of type I cells in taste buds. J Comp Neurol 497(1): 1–12
Baskin DG, Breininger JF, et al. (1999) Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus. Diabetes 48(4): 828–33
Batterham RL, Cowley MA, et al. (2002) Gut hormone PYY(3–36) physiologically inhibits food intake. Nature 418(6898): 650–04
Batterham RL, ffytche DH, et al. (2007) PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans. Nature 450(7166): 106–09
Beckman ME, Whitehead MC (1991) Intramedullary connections of the rostral nucleus of the solitary tract in the hamster. Brain Res 557(1–2): 265–79
Beckstead RM, Morse JR, et al. (1980) The nucleus of the solitary tract in the monkey: projections to the thalamus and brain stem nuclei. J Comp Neurol 190(2): 259–82
Benabid AL, Chabardes S, et al. (2009) Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson’s disease. Lancet Neurol 8(1): 67–81
Berridge KC (1996) Food reward: brain substrates of wanting and liking. Neurosci Biobehav Rev 20(1): 1–25
Berridge KC (2009) ‘Liking’ and ‘wanting’ food rewards: brain substrates and roles in eating disorders. Physiol Behav 97(5): 537–50
Berthoud HR (2008) Vagal and hormonal gut-brain communication: from satiation to satisfaction. Neurogastroenterol Motil 20(Suppl 1): 64–72
Biebermann H, Castaneda TR, et al. (2006) A role for beta-melanocyte-stimulating hormone in human body-weight regulation. Cell Metab 3(2): 141–46
Blevins JE, Stanley BG, et al. (2000) Brain regions where cholecystokinin suppresses feeding in rats. Brain Res 860(1–2): 1–10
Booth DA (1968) Effects of intrahypothalamic glucose injection on eating and drinking elicited by insulin. J Comp Physiol Psychol 65(1): 13–16
Bray GA, Greenway FL (2007) Pharmacological treatment of the overweight patient. Pharmacol Rev 59(2): 151–84
Bray GA, Wilson JF (2008) In the clinic. Obesity. Ann Intern Med 149(7): ITC4-1-15; quiz ITC4-16
Broadwell RD, Brightman MW (1976) Entry of peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood. J Comp Neurol 166(3): 257–83
Brobeck JR, Tepperman J, et al. (1943) Experimental hypothalamic hyperphagia in the albino rat. Yale J Biol Med 15:831–53
Broberger C (2005) Brain regulation of food intake and appetite: molecules and networks. J Intern Med 258(4): 301–27
Brog JS, Salyapongse A, et al. (1993) The patterns of afferent innervation of the core and shell in the “accumbens” part of the rat ventral striatum: immunohistochemical detection of retrogradely transported fluoro-gold. J Comp Neurol 338(2): 255–78
Brubaker PL, Anini Y (2003) Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2. Can J Physiol Pharmacol 81(11): 1005–12
Buchwald H, Estok R, et al. (2007) Trends in mortality in bariatric surgery: a systematic review and meta-analysis. Surgery 142(4): 621–32; discussion 632-35
Bult MJ, van Dalen T, et al. (2008) Surgical treatment of obesity. Eur J Endocrinol 158(2): 135–45
Camilleri M, Toouli J, et al. (2008) Intra-abdominal vagal blocking (VBLOC therapy): clinical results with a new implantable medical device. Surgery 143(6): 723–31
Cechetto DF, Saper CB (1987) Evidence for a viscerotopic sensory representation in the cortex and thalamus in the rat. J Comp Neurol 262(1): 27–45
Chuang HH, Neuhausser WM, et al. (2004) The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron 43(6): 859–69
Contreras RJ, Gomez MM, et al. (1980) Central origins of cranial nerve parasympathetic neurons in the rat. J Comp Neurol 190(2): 373–94
Cota D, Proulx K, et al. (2006) Hypothalamic mTOR signaling regulates food intake. Science 312(5775): 927–30
Cowley MA, Smart JL, et al. (2001) Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411(6836): 480–84
Cummings DE, Overduin J (2007) Gastrointestinal regulation of food intake. J Clin Invest 117(1): 13–23
Cummings DE, Purnell JQ, et al. (2001) A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50(8): 1714–19
Dakin CL, Gunn I, et al. (2001) Oxyntomodulin inhibits food intake in the rat. Endocrinology 142(10): 4244–50
de Araujo IE, Oliveira-Maia AJ, et al. (2008) Food reward in the absence of taste receptor signaling. Neuron 57(6): 930–41
DeSimone JA, Lyall V, et al. (2001) A novel pharmacological probe links the amilorideinsensitive NaCl, KCl, and NH(4)Cl chorda tympani taste responses. J Neurophysiol 86(5): 2638–41
Dhillon H, Zigman JM, et al. (2006) Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 49(2): 191–203
Di Lorenzo PM (1990) Corticofugal influence on taste responses in the parabrachial pons of the rat. Brain Res 530(1): 73–84
Elias CF, Saper CB, et al. (1998) Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J Comp Neurol 402(4): 442–59
Faulconbridge LF, Cummings DE, et al. (2003) Hyperphagic effects of brainstem ghrelin administration. Diabetes 52(9): 2260–65
Figlewicz DP (2003) Adiposity signals and food reward: expanding the CNS roles of insulin and leptin. Am J Physiol Regul Integr Comp Physiol 284(4): R882–92
Finger TE, Danilova V, et al. (2005) ATP signaling is crucial for communication from taste buds to gustatory nerves. Science 310(5753): 1495–99
French SJ, Totterdell S (2002) Hippocampal and prefrontal cortical inputs monosynaptically converge with individual projection neurons of the nucleus accumbens. J Comp Neurol 446(2): 151–65
French SJ, Totterdell S (2003) Individual nucleus accumbens-projection neurons receive both basolateral amygdala and ventral subicular afferents in rats. Neuroscience 119(1): 19–31
Friedman JM (2009) Obesity: causes and control of excess body fat. Nature 459(7245): 340–42
Fulwiler CE, Saper CB (1984) Subnuclear organization of the efferent connections of the parabrachial nucleus in the rat. Brain Res 319(3): 229–59
Gao Q, Horvath TL (2007) Neurobiology of feeding and energy expenditure. Annu Rev Neurosci 30: 367–98
Glenn JF, Erickson RP (1976) Gastric modulation of gustatory afferent activity. Physiol Behav (16): 561–68
Goto Y, Grace AA (2005) Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior. Nat Neurosci 8(6): 805–12
Gottig S, Daskalakis M, et al. (2009) Analysis of safety and efficacy of intragastric balloon in extremely obese patients. Obes Surg 19(6): 677–83
Grill HJ, Kaplan JM (2001) Interoceptive and integrative contributions of forebrain and brainstem to energy balance control. Int J Obes Relat Metab Disord 25(Suppl 5): S 73–77
Grill HJ, Norgren R (1978) Chronically decerebrate rats demonstrate satiation but not bait shyness. Science 201(4352): 267–69
Grill HJ, Norgren R (1978) The taste reactivity test. II. Mimetic responses to gustatory stimuli in chronic thalamic and chronic decerebrate rats. Brain Res 143(2): 281–97
Grill HJ, Schwartz MW, et al. (2002) Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake. Endocrinology 143(1): 239–46
Hajnal A, Smith GP, et al. (2004) Oral sucrose stimulation increases accumbens dopamine in the rat. Am J Physiol Regul Integr Comp Physiol 286(1): R31–37
Halata Z, Munger BL (1983) The sensory innervation of primate facial skin. II. Vermilion border and mucosa of lip. Brain Res 286(1): 81–107
Halpern CH, Wolf JA, et al. (2008) Deep brain stimulation in the treatment of obesity. J Neurosurg 109(4): 625–34
Hamani C, McAndrews MP, et al. (2008) Memory enhancement induced by hypothalamic= fornix deep brain stimulation. Ann Neurol 63(1): 119–23
Hanamori T, Kunitake T, et al. (1998) Responses of neurons in the insular cortex to gustatory, visceral, and nociceptive stimuli in rats. J Neurophysiol 79(5): 2535–45
Hasler WL (2009) Methods of gastric electrical stimulation and pacing: a review of their benefits and mechanisms of action in gastroparesis and obesity. Neurogastroenterol Motil 21(3): 229–43
Hayama T, Ito S, et al. (1987) Receptive field properties of the parabrachiothalamic taste and mechanoreceptive neurons in rats. Exp Brain Res 68(3): 458–65
Heath TP, Melichar JK, et al. (2006) Human taste thresholds are modulated by serotonin and noradrenaline. J Neurosci 26(49): 12664–71
Heck GL, Mierson S, et al. (1984) Salt taste transduction occurs through an amiloridesensitive sodium transport pathway. Science 223(4634): 403–05
Herbert H, Moga MM, et al. (1990) Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat. J Comp Neurol 293(4): 540–80
Hermann GE, Kohlerman NJ, et al. (1983) Hepatic-vagal and gustatory afferent interactions in the brainstem of the rat. J Auton Nerv Syst 9(2–3): 477–95
Hetherington AW, Ranson SW (1940) Hypothalamic lesions and adipocity in the rat. Anat Record 78: 149
Hoebel BG, Teitelbaum P (1962) Hypothalamic control of feeding and self-stimulation. Science 135:375–77
Horvath TL, Diano S, et al. (1999) Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. J Neurosci 19(3): 1072–87
Huang AL, Chen X, et al. (2006) The cells and logic for mammalian sour taste detection. Nature 442(7105): 934–38
Huang YA, Maruyama Y, et al. (2008) Norepinephrine is coreleased with serotonin in mouse taste buds. J Neurosci 28(49): 13088–93
Huang YJ, Maruyama Y, et al. (2007) The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds. Proc Natl Acad Sci USA 104(15): 6436–41
Huque T, Cowart BJ, et al. (2009) Sour ageusia in two individuals implicates ion channels of the ASIC and PKD families in human sour taste perception at the anterior tongue. PLoS One 4(10): e7347
Ishimaru Y, Inada H, et al. (2006) Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci USA 103(33): 12569–74
Kadohisa M, Verhagen JV, et al. (2005) The primate amygdala: Neuronal representations of the viscosity, fat texture, temperature, grittiness and taste of foods. Neuroscience 132(1): 33–48
Karimnamazi H, Travers JB (1998) Differential projections from gustatory responsive regions of the parabrachial nucleus to the medulla and forebrain. Brain Res 813(2): 283–302
Karimnamazi H, Travers SP, et al. (2002) Oral and gastric input to the parabrachial nucleus of the rat. Brain Res 957(2): 193–206
Katsuura G, Asakawa A, et al. (2002) Roles of pancreatic polypeptide in regulation of food intake. Peptides 23(2): 323–29
Kawamura Y, Okamoto J, et al. (1968) A role of oral afferents in aversion to taste solutions. Physiol Behav 3: 537–42
Keesey RE, Powley TL (2008) Body energy homeostasis. Appetite 51(3): 442–45
Keith SW, Redden DT, et al. (2006) Putative contributors to the secular increase in obesity: exploring the roads less traveled. Int J Obes (Lond) 30(11): 1585–94
Kelley AE, Baldo BA, et al. (2005) Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward. Physiol Behav 86(5): 773–95
Kennedy GC (1953) The role of depot fat in the hypothalamic control of food intake in the rat. Proc R Soc Lond B Biol Sci 140(901): 578–96
Kirouac GJ, Ganguly PK, (1995) Topographical organization in the nucleus accumbens of afferents from the basolateral amygdala and efferents to the lateral hypothalamus. Neuroscience 67(3): 625–30
Kosar E, Grill HJ, et al. (1986) Gustatory cortex in the rat. II. Thalamocortical projections. Brain Res 379(2): 342–52
Krettek JE, Price JL (1977) Projections from the amygdaloid complex to the cerebral cortex and thalamus in the rat and cat. J Comp Neurol 172(4): 687–722
Krettek JE, Price JL (1978) Amygdaloid projections to subcortical structures within the basal forebrain and brainstem in the rat and cat. J Comp Neurol 178(2): 225–54
Lam TK, Pocai A, et al. (2005) Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat Med 11(3): 320–7
Lam TK, Schwartz GJ, et al. (2005) “Hypothalamic sensing of fatty acids. Nat Neurosci 8(5): 579–84
Langhans W (1996) Role of the liver in the metabolic control of eating: what we know — and what we do not know. Neurosci Biobehav Rev 20(1): 145–53
Larson PS (2008) Deep brain stimulation for psychiatric disorders. Neurotherapeutics 5(1): 50–8
Laugerette F, Passilly-Degrace P, et al. (2005) CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions. J Clin Invest 115(11): 3177–84
Li CS, Cho YK, et al. (2005) Modulation of parabrachial taste neurons by electrical and chemical stimulation of the lateral hypothalamus and amygdala. J Neurophysiol 93(3): 1183–96
Liu L, Simon SA (1996) Capsaicin-induced currents with distinct desensitization and Ca2+ dependence in rat trigeminal ganglion cells. J Neurophysiol 75(4): 1503–14
Loftus TM, Jaworsky DE, et al. (2000) Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288(5475): 2379–81
Lundy RF Jr, Norgren R (2004) Gustatory system. In: Paxinos G (ed) The Rat Nervous System. Academic Press, San Diego, CA and London, Elsevier, pp 891–921
Lutz TA, Del Prete E, et al. (1995) Subdiaphragmatic vagotomy does not influence the anorectic effect of amylin. Peptides 16(3): 457–62
Lutz TA, Geary N, et al. (1995) Amylin decreases meal size in rats. Physiol Behav 58(6): 1197–202
Lyall V, Heck GL, et al. (2004) The mammalian amiloride-insensitive non-specific salt taste receptor is a vanilloid receptor-1 variant. J Physiol 558(Pt 1): 147–59
Margolskee RF (2002) Molecular mechanisms of bitter and sweet taste transduction. J Biol Chem 277(1): 1–4
Margolskee RF, Dyer J, et al. (2007) T1R3 and gustducin in gut sense sugars to regulate expression of Naα-glucose cotransporter 1. Proc Natl Acad Sci U S A 104(38): 15075–80
Matsumoto I, Emori Y, et al. (2001) A comparative study of three cranial sensory ganglia projecting into the oral cavity: in situ hybridization analyses of neurotrophin receptors and thermosensitive cation channels. Brain Res Mol Brain Res 93(2): 105–12
Mayer J (1953) Glucostatic mechanism of regulation of food intake. N Engl J Med 249(1): 13–16
Miller IJ Jr (1995) Anatomy of the peripheral taste system. In: Doty RL (ed) Handbook of Olfaction and Gustation. Marcel Dekker Inc., New York, pp 521–47
Minokoshi Y, Alquier T, et al. (2004) AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428(6982): 569–74
Mithieux G, Misery P, et al. (2005) Portal sensing of intestinal gluconeogenesis is a mechanistic link in the diminution of food intake induced by diet protein. Cell Metab 2(5): 321–29
Moran TH, Robinson PH, et al. (1986) Two brain cholecystokinin receptors: implications for behavioral actions. Brain Res 362(1): 175–79
Mueller KL, Hoon MA, et al. (2005) The receptors and coding logic for bitter taste. Nature 434(7030): 225–29
Murray RG (1971) Ultrastructure of taste receptors. In: Beidler LM (ed) Handbook of Sensory Physiology. Volume IV. Chemical Senses Part 2: Taste. Springer-Verlag, Berlin, pp 31–50
Nakano Y, Oomura Y, et al. (1986) Feeding-related activity of glucose-and morphinesensitive neurons in the monkey amygdala. Brain Res 399(1): 167–72
Nguyen NT, Wilson SE (2007) Complications of antiobesity surgery. Nat Clin Pract Gastroenterol Hepatol 4(3): 138–47
Niijima A (1969) Afferent impulse discharges from glucoreceptors in the liver of the guinea pig. Ann NY Acad Sci 157(2): 690–700
Nomura T, Ogawa H(1985) The taste and mechanical response properties of neurons in the parvicellular part of the thalamic posteromedial ventral nucleus of the rat. Neurosci Res 3(2): 91–105
Norgren R (1978) Projections from the nucleus of the solitary tract in the rat. Neuroscience 3(2): 207–18
Norgren R (1984) Central neural mechanisms of taste. In: Darien-Smith I (ed) Handbook of Physiology-The Nervous System III. Sensory Processes 1. American Physiological Society, Washington, DC, pp 1087–128
Norgren R, Leonard CM (1971) Taste pathways in rat brainstem. Science 173(2): 1136–39
Norgren R, Leonard CM (1973) Ascending central gustatory pathways. J Comp Neurol 150(2): 217–37
O’Rahilly S, Farooqi IS (2006) Genetics of obesity. Philos Trans R Soc Lond B Biol Sci 361(1471): 1095–105
Obici S, Feng Z, et al. (2002) Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci 5(6): 566–72
Obici S, Feng Z, et al. (2002) Central administration of oleic acid inhibits glucose production and food intake. Diabetes 51(2): 271–75
Ogawa H, Hayama T, et al. (1984) Location and taste responses of parabrachio-thalamic relay neurons in rats. Exp Neurol 83(3): 507–17
Ogawa H, Ito S, et al. (1990) Taste area in granular and dysgranular insular cortices in the rat identified by stimulation of the entire oral cavity. Neurosci Res 9(3): 196–201
Ollmann MM, Wilson BD, et al. (1997) Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278(5335): 135–38
Orbach J, Andrews WH (1973) Stimulation of afferent nerve terminals in the perfused rabbit liver by sodium salts of some long-chain fatty acids. Q J Exp Physiol Cogn Med Sci 58(3): 267–74
Ottersen OP (1982) Connections of the amygdala of the rat. IV: Corticoamygdaloid and intraamygdaloid connections as studied with axonal transport of horseradish peroxidase. J Comp Neurol 205(1): 30–48
Ottersen OP, Ben-Ari Y (1979) Afferent connections to the amygdaloid complex of the rat and cat. I. Projections from the thalamus. J Comp Neurol 187(2): 401–24
Pardal R, Lopez-Barneo J (2002) Low glucose-sensing cells in the carotid body. Nat Neurosci 5(3): 197–98
Phillipson OT (1979) Afferent projections to the ventral tegmental area of Tsai and interfascicular nucleus: a horseradish peroxidase study in the rat. J Comp Neurol 187(1): 117–43
Powley TL, Phillips RJ (2004) Gastric satiation is volumetric, intestinal satiation is nutritive. Physiol Behav 82(1): 69–74
Pritchard TC, Hamilton RB, et al. (2000) Projections of the parabrachial nucleus in the old world monkey. Exp Neurol 165(1): 101–17
Qu D, Ludwig DS, et al. (1996) A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 380(6571): 243–47
Quaade F, Vaernet K, et al. (1974) Stereotaxic stimulation and electrocoagulation of the lateral hypothalamus in obese humans. Acta Neurochir (Wien) 30(1–2): 111–17
Ricardo JA, Koh ET (1978) Anatomical evidence of direct projections from the nucleus of the solitary tract to the hypothalamus, amygdala, and other forebrain structures in the rat. Brain Res 153(1): 1–26
Ritter RC, Slusser PG, et al. (1981) Glucoreceptors controlling feeding and blood glucose: location in the hindbrain. Science 213(4506): 451–52
Rolls ET, Baylis LL (1994) Gustatory, olfactory, and visual convergence within the primate orbitofrontal cortex. J Neurosci 14: 5437–52
Rolls ET, Yaxley S, et al. (1990) Gustatory responses of single neurons in the caudolateral orbitofrontal cortex of the macaque monkey. J Neurophysiol 64(4): 1055–66
Rowland NE, Crews EC, et al. (1997) Comparison of Fos induced in rat brain by GLP-1 and amylin. Regul Pept 71(3): 171–74
Sakurai T, Amemiya A, et al. (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92(4): 573–85
Sani S, Jobe K, et al. (2007) Deep brain stimulation for treatment of obesity in rats. J Neurosurg 107(4): 809–13
Schwartz MW, Porte D Jr (2005) Diabetes, obesity, and the brain. Science 307(5708): 375–79
Schwartz MW, Woods SC, et al. (2000) Central nervous system control of food intake. Nature 404(6778): 661–71
Sclafani A (2004) Oral and postoral determinants of food reward. Physiol Behav 81(5): 773–79
Scott TR, Plata-Salaman CR (1999) Taste in the monkey cortex. Physiol Behav 67(4): 489–511
Shapiro RE, Miselis RR (1985) The central neural connections of the area postrema of the rat. J Comp Neurol 234(3): 344–64
Shi CJ, Cassell MD (1998) Cortical, thalamic, and amygdaloid connections of the anterior and posterior insular cortices. J Comp Neurol 399(4): 440–68
Simon SA, de Araujo IE, et al. (2006) The neural mechanisms of gustation: a distributed processing code. Nat Rev Neurosci 7(11): 890–901
Simons CT, Boucher Y, et al. (2003) Suppression of central taste transmission by oral capsaicin. J Neurosci 23(3): 978–85
Small DM, Prescott J (2005) Odor=taste integration and the perception of flavor. Exp Brain Res 166(3–4): 345–57
Small DM, Zald DH, et al. (1999) Human cortical gustatory areas: a review of functional neuroimaging data. NeuroReport 10(1): 7–14
Smith GP, Jerome C, et al. (1981) Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat. Science 213(4511): 1036–37
Spanswick D, Smith MA, et al. (2000) Insulin activates ATP-sensitive Kα channels in hypothalamic neurons of lean, but not obese rats. Nat Neurosci 3(8): 757–58
Spector AC, Travers SP (2005) The representation of taste quality in the mammalian nervous system. Behav Cogn Neurosci Rev 4(3): 143–91
Stein CJ, Colditz GA (2004) The epidemic of obesity. J Clin Endocrinol Metab 89(6): 2522–25
Stellar E (1954) The physiology of motivation. ychol Rev 61(1): 5–22
Stratford TR, Kelley AE (1999) Evidence of a functional relationship between the nucleus accumbens shell and lateral hypothalamus subserving the control of feeding behavior. J Neurosci 19(24): 11040–48
Talavera K, Yasumatsu K, et al. (2005) Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature 438(7070): 1022–25
Tanaka K, Inoue S, et al. (1990) Amino acid sensors sensitive to alanine and leucine exist in the hepato-portal system in the rat. J Auton Nerv Syst 31(1): 41–46
Tomchik SM, Berg S, et al. (2007) Breadth of tuning and taste coding in mammalian taste buds. J Neurosci 27(40): 10840–48
Tordoff MG, Friedman MI (1986) Hepatic portal glucose infusions decrease food intake and increase food preference. Am J Physiol 251(1 Pt 2): R192–96
Torvik A (1956) Afferent connections to the sensory trigeminal nuclei, the nucleus of the solitary tract and adjacent structures; an experimental study in the rat. J Comp Neurol 106(1): 51–141
Travers JB, Norgren R (1983) Afferent projections to the oral motor nuclei in the rat. J Comp Neurol 220(3): 280–98
Treesukosol Y, Lyall V, et al. (2007) A psychophysical and electrophysiological analysis of salt taste in Trpv1 null mice. Am J Physiol Regul Integr Comp Physiol 292(5): R1799–809
Tschop M, Smiley DL, et al. (2000) Ghrelin induces adiposity in rodents. Nature 407(6806): 908–13
Turton MD, O’Shea D, et al. (1996) A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379(6560): 69–72
van der Kooy D, Koda LY, et al. (1984) The organization of projections from the cortex, amygdala, and hypothalamus to the nucleus of the solitary tract in rat. J Comp Neurol 224(1): 1–24
Vandenbeuch A, Clapp TR, et al. (2008) Amiloride-sensitive channels in type I fungiform taste cells in mouse. BMC Neurosci 9: 1
Volkow ND, O’Brien CP (2007) Issues for DSM-V: should obesity be included as a brain disorder? Am J Psychiatry 164(5): 708–10
Wang FB, Powley TL (2000) Topographic inventories of vagal afferents in gastrointestinal muscle. J Comp Neurol 421(3): 302–24
Wang R, Liu X, et al. (2004) The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptides. Diabetes 53(8): 1959–65
Wang Y, Erickson RP, et al. (1993) Selectivity of lingual nerve fibers to chemical stimuli. J Gen Physiol 101(6): 843–66
Werther GA, Hogg A, et al. (1987) Localization and characterization of insulin receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry. Endocrinology 121(4): 1562–70
Willesen MG, Kristensen P, et al. (1999) Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology 70(5): 306–16
Wilson CS (2002) Reasons for eating: personal experiences in nutrition and anthropology. Appetite 38(1): 63–7
Wise RA (2006) Role of brain dopamine in food reward and reinforcement. Philos Trans R Soc Lond B Biol Sci 361(1471): 1149–58
Wong GT, Gannon KS, et al. (1996) Transduction of bitter and sweet taste by gustducin. Nature 381(6585): 796–800
Woolley JD, Lee BS, et al. (2006) Nucleus accumbens opioids regulate flavor-based preferences in food consumption. Neuroscience 143(1): 309–17
Yang R, Crowley HH, et al. (2000) Taste cells with synapses in rat circumvallate papillae display SNAP-25-like immunoreactivity. J Comp Neurol 424(2) 205–15
Yasui Y, Breder CD, et al. (1991) Autonomic responses and efferent pathways from the insular cortex in the rat. J Comp Neurol 303(3): 355–74
Zaborszky L, Beinfeld MC, et al. (1984) Brainstem projection to the hypothalamic ventromedial nucleus in the rat: a CCK-containing long ascending pathway. Brain Res 303(2): 225–31
Zaborszky L, Makara GB (1979) Intrahypothalamic connections: an electron microscopic study in the rat. Exp Brain Res 34(2): 201–15
Zhang Y, Hoon MA, et al. (2003) Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell 112(3): 293–301
Zhang Y, Proenca R, et al. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372(6505): 425–32
Zhao GQ, Zhang Y, et al. (2003) The receptors for mammalian sweet and umami taste. Cell 115(3): 255–66
Zheng H, Berthoud HR (2008) Neural systems controlling the drive to eat: mind versus metabolism. Physiology (Bethesda) 23: 75–83
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Oliveira-Maia, A.J., Roberts, C.D., Simon, S.A., Nicolelis, M.A.L. (2011). Gustatory and reward brain circuits in the control of food intake. In: Pickard, J.D., et al. Advances and Technical Standards in Neurosurgery. Advances and Technical Standards in Neurosurgery, vol 36. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0179-7_3
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