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Abstract

The contact urticaria syndrome (CUS) (immediate-contact reactions), first defined as a biological entity in 1975 by Maibach and Johnson [1], comprises a heterogeneous group of inflammatory reactions that usually appear within minutes after cutaneous or mucosal contact with the eliciting agent — although delayed-onset reactions are sometimes observed [2] — and disappear within 24 h, usually within a few hours. The term “syndrome” clearly illustrates the biological and clinical polymorphism of this entity, which may be either localized or generalized and may involve organs other than the skin, such as the respiratory or the gastrointestinal tract, as well as the vascular system, displaying a wide spectrum of clinical manifestations, ranging from mild erythema and/or itching, to death [3–5]. Numerous cases of CUS continue to be reported and the list of etiologic agents constantly increases, providing evidence for the high frequency of these entities [6–10]. A complete overview of CUS is found in Amin et al. [10].

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Ale, S.I., Maibach, H.I. (2000). Occupational Contact Urticaria. In: Kanerva, L., Wahlberg, J.E., Elsner, P., Maibach, H.I. (eds) Handbook of Occupational Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07677-4_24

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