Abstract
Irritant contact dermatitis (ICD), defined as “a nonim-munologic local inflammatory reaction characterised by erythema, oedema or corrosion following single or repeated application of a chemical substance to an identical cutaneous site” (Mathias and Maibach 1978), is a leading cause of occupational disease in dermatology and causes economic damage to workers, companies, and social-security systems worldwide. The perception of ICD as more trivial than the more intellectually appealing problem of allergic sensitisation has recently changed dramatically. In Germany, skin diseases are the second most frequent occupational disease following musculoskeletal disorders, and most occupational dermatoses are cases of contact dermatitis. Among these, ICD is probably more frequent than allergic contact dermatitis (ACD), although reliable data are still very limited. In contrast to ACD, ICD is defined as being the result of primarily nonspecific damage to the skin. It is not a clinical entity but rather a spectrum of diseases.
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References
Aoki T, Kageyama R (1989) Three cases of dry cleaning dermatitis. Nippon Hifuka Gakkai Zasshi 9:1035–1038
Ashworth J, Rycroft RJG, Waddy RS (1993) Irritant contact dermatitis in warehouse employees. Occup Med 43:32–34
Avnstorp C (1996) Irritant cement eczema. In: van der Valk PGM, Maibach HI (eds) The irritant contact dermatitis syndrome. CRC, New York, pp 111–119
Basketter DA, Reynolds FS, York M (1997) Predictive testing in contact dermatitis: irritant dermatitis. Clin Dermatol 15: 637–644
Berardesca E, Distante F (1995) Mechanisms of skin irritation. In: Eisner P, Maibach HI (eds) Irritant dermatitis: new clinical and experimental aspects. Karger, Basel, pp 1–8
Berardesca E, Maibach HI (1988) Racial differences in sodium lauryl sulphate induced cutaneous irritation: black and white. Contact Dermatitis 18:65–70
Berndt U, Hinnen U, Iliev D, Eisner P (1999) Risk factors for hand eczema in metal worker trainees (in German). Allergologie 22:195
Binnick AN (1981) Allergic and irritant contact dermatitis. Compr Ther 1:17–21
Brasch L, Burgard J, Sterry W (1992) Common pathogenetic pathways in allergic and irritant contact dermatitis. J Invest Dermatol 98:166–170
Cleenewerck MB, Martin P (1996) Irritants: food. In: van der Valk PGM, Maibach HI (eds) The irritant contact dermatitis syndrome. CRC, New York, pp 157–184
Coenraads PJ, Smit J (1995) Epidemiology. In: Rycroft RJG, Menné T, Frosch PJ (eds) Textbook of contact dermatitis. Springer, Berlin Heidelberg New York, pp 133–150
Conde-Salazar L, Gomez J, Meza B, Guimaraens D (1993) Artefactual irritant contact dermatitis. Contact Dermatitis 28:246
Cronin E (1980) Contact dermatitis. Churchill Livingston, Edingburgh
Cronin E (1987) Dermatitis of the hands in caterers. Contact Dermatitis 17:265–269
Cronin E (1995) Hand eczema. In: Rycroft RJG, Menné T, Frosch PJ (eds) Textbook of contact dermatitis. Springer, Berlin Heidelberg New York, pp 207–218
Darre E, Vedel P, Jensen JS (1987) Skin protection against methylmethacrylate. Acta Orthop Scand 58:236–238
de Boer EM, van Ketel WG, Bruynzeel DP (1989) Dermatoses in metal workers I: Irritant contact dermatitis. Contact Dermatitis 20:212–218
Diepgen TL, Coenraads PJ (1995) What can we learn from epidemiological studies on irritant contact dermatitis? In: Eisner P, Maibach HI (eds) Irritant dermatitis: new clinical and experimental aspects. Karger, Basel, pp 18–27
Dooms-Goossens AE, Debusschere KM, Gevers DM, Dupre KM, Degreef HJ, Loncke JP, Snauwoert JE (1986) Contact dermatitis caused by airborne agent. A review and case reports. J Am Acad Dermatol 15:1–10
Eichmann A, Amgwerd D (1992) Toxische Kontaktdermatitis. Schweiz Rundsch Med Prax 19:615–617
Eisner P (1994) Irritant dermatitis in the workplace. Dermatol Clin 12:461–467
Eisner P, Maibach HI (1993) Irritant and allergic contact dermatitis. In: Eisner P, Martius J (eds) Vulvovaginitis. Dekker, New York
Eisner P, Baxmann F, Liehr HM (1995) Metal working fluid dermatitis: a comparative follow-up study in patients with irritant and non-irritant hand dermatitis. In: Eisner P, Maibach HI (eds) Irritant dermatitis: new clinical and experimental aspects. Karger, Basel, pp 77–86
Emtestam L, Ollmar S (1993) Electrical impedance index in human skin: measurements after occlusion in 5 anatomical regions and in mild irritant contact dermatitis. Contact Dermatitis 28:104–108
Estlander T, Jolanki R (1988) How to protect the hands. Dermatol Clin 6:105–114
Foulds IS, Koh D (1990) Dermatitis from metalworking fluids. Clin Exp Dermatol 15:157–162
Frosch PJ (1989) Irritant contact dermatitis. In: Frosch PJ, Dooms-Goossens A, Lachapelle JM, Rycroft RJG, Scheper RJ (eds) Current topics in contact dermatitis. Springer, Berlin Heidelberg New York, pp 385–403
Frosch PJ (1995) Cutaneous irritation. In: Rycroft RJG, Menné T, Frosch PJ (eds) Textbook of contact dermatitis. Springer, Berlin, pp 28–61
Frosch PJ, Kligman AM (1977) A method for appraising the stinging capacity of topically applied substances. Soc Cosmetic Chem 28:197–209
Gan SL, Goh CL, Lee CS (1987) Occupational dermatitis among sanders in the furniture industry. Contact Dermatitis 17: 237–240
Gaspari AA (1997) The role of keratinocytes in the pathophysiology of contact dermatitis. Immunol Allergy Clin North Am 17:377–405
Gawkrodger DJ, Lloyd MH, Hunter JA (1986) Occupational skin disease in hospital cleaning and kitchen workers. Contact Dermatitis 15:132–135
Ghadially R, Brown BE, Sequeira-Martin SM, Feingold KR, Elias PM (1995) The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model. J Clin Invest 95:2281–2290
Goh CL (1987) Occupational skin disease in Singapore: epidemiology and causative agents. Ann Acad Med Singapore 16: 303–305
Goh CL (1995) Noneczematous contact reactions. In: Rycroft RJG, Menné T, Frosch PJ (eds) Textbook of contact dermatitis. Springer, Berlin Heidelberg New York, pp 221–236
Goh CL (1997) Prognosis of contact and occupational dermatitis. Clin Dermatol 15:655–659
Goh CL, Yuen R (1994) A study of occupational skin disease in the metal industry (1986–1990). Ann Acad Med Singapore 23:639–644
Goldner R (1994) Work-related irritant contact dermatitis. Occup Med 9:37–44
Goldschmidt H, Panizzon RG (1991) Radiation therapy of benign tumors, hyperplasias, and dermatoses. Springer, Berlin Heidelberg New York
Hafner J, Rüegger M, Kralicek P, Eisner P (1995) Airborne irritant contact dermatitis from metal dust adhering to semisynthetic working suits. Contact Dermatitis 32:285–288
Henriksen H (1982) Selection of materials for protective gloves. Polymer membranes for protection against contact with epoxy preparations. Danish Directorate of Labour Inspection Services, Copenhagen
Hogan DJ (1996) The prognosis of irritant contact dermatitis. In: van der Valk PGM, Maibach HI (eds) The irritant contact dermatitis syndrome. CRC, New York, pp 9–15
Hogan DJ, Dannaker CJ, Maibach HI (1990) The prognosis of contact dermatitis. J Am Acad Dermatol 23:300–307
Hurwitz RM, Rivera HP, Guin JD (1984) Black-spot poison ivy dermatitis. An acute irritant contact dermatitis superimposed upon an allergic contact dermatitis. Am J Dermatopathol 6:319–322
Iliev D, Eisner P (1997) Clinical irritant contact dermatitis syndromes. Immunol Allergy Clin North Am 17:365–375
Iliev D, Hinnen U, Eisner P (1998) Skin bioengineering methods in occupational dermatology. In: Eisner P, Barel AO, Berardesca E, Gabard E, Serup J (eds) Skin bioengineering techniques and applications in dermatology and cosmetology. Karger, Basel, pp 145–150
Itschner L, Hinnen U, Eisner P (1996) Prevention of hand eczema in the metal-working industry: Risk awareness and behaviour of metal worker apprentices. Dermatology 193:226–229
Kanerva L, Estlander T, Jolanki R (1988) Occupational skin disease in Finland. An analysis of 10 years of statistics from an occupational dermatology clinic. Int Arch Occup Environ Health 60:89–94
Kassis V, Vedel P, Darre E (1984) Contact dermatitis to methyl methacrylate. Contact Dermatitis 11:26–28
Lachapelle JM (1986) Industrial airborne irritant or allergic contact dermatitis. Contact Dermatitis 14:137–145
Lachapelle JM (1995a) Histopathological and immunohistopathological features of irritant and allergic contact dermatitis. In: Rycroft RJG, Menné T, Frosch PJ (eds) Textbook of contact dermatitis. Springer, Berlin Heidelberg New York, pp 91–101
Lachapelle JM (1995b) Principles of prevention and protection in contact dermatitis (with special reference tp occupational dermatology). In: Rycroft RJG, Menné T, Frosch PJ (eds) Textbook of contact dermatitis. Springer, Berlin Heidelberg New York, pp 695–702
Lammintausta K, Maibach HI (1990) Contact dermatitis due to irritation: general principles, etiology, and histology. In: Adams RM (ed) Occupational skin disease. Saunders, Philadelphia, pp 1–15
Lammintausta K, Maibach HI, Wilson D (1987) Irritant reactivity in males and females. Contact Dermatitis 17:276–280
Lammintausta K, Maibach HI, Wilson D (1988) Mechanisms of subjective (sensory) irritation. Propensity to non-immuno-logic contact urticaria and objective irritation in stingers. Derm Beruf Umwelt 36:45–49
Lauerma AI, Stein BD, Homey B, Lee CH, Bloom E, Maibach HI (1994) Topical FK506: suppression of allergic and irritant contact dermatitis in the guinea pig. Arch Dermatol Res 286:337–340
Lee CH, Maibach HI (1994) Study of cumulative irritant contact dermatitis in man utilizing open application on subclinically irritated skin. Contact Dermatitis 30:271–275
Malten KE (1981) Thoughts on irritant contact dermatitis. Contact Dermatitis 7:238–247
Malten KE, den Arend JA (1985) Irritant contact dermatitis: traumiterative and cumulative impairment by cosmetics, climate, and other daily loads. Derm Beruf Umwelt 33:125–132
Malten KE, den Arend JA, Wiggers RE (1979) Delayed irritation: hexanediol diacrylate and butanediol diacrylate. Contact Dermatitis 3:178–184
Mathias CG (1990) Prevention of occupational contact dermatitis. J Am Acad Dermatol 23:742–748
Mathias CGT, Maibach HI (1978) Dermatotoxicology monographs. I. Cutaneous irritation: factors influencing the response to irritants. Clin Toxicol 13:333–346
Meding B (1990) Epidemiology of hand eczema in an industrial city. Acta Derm Venereol Suppl (Stockh) 153:1–43
Meding B, Swanbeck G (1990) Occupational hand eczema in an industrial city. Contact Dermatitis 22:13–23
Mellström GA (1996) Prevention of irritant dermatitis by gloves. In: van der Valk PGM, Maibach HI (eds) The irritant contact dermatitis syndrome. CRC, New York, pp 367–377
Mellström GA, Wahlberg JE, Maibach HI (1994) Protective gloves for occupational use. CRC, Boca Raton
Mize N, Johnson J, Hansch C (1995) Quantitative structure-activity relationship and cytotoxicity. In: Eisner P, Maibach HI (eds) Irritant dermatits. New clinical and experimental aspects. Karger, Basel, pp 224–229
Moshell AN (1997) Workshop on irritant contact dermatitis. Am J Contact Dermatitis 8:79–105
Mozzanica N (1992) Pathogenetic aspects of allergic and irritant contact dermatitis. Clin Dermatol 10:115–121
Nilsson E (1986) Individual and environmental risk factors for hand eczema in hospital workers. Acta Derm Venereol Suppl (Stockh) 128:1–63
Patil S, Maibach HI (1994) Effect of age and sex on the elicitation of irritant contact dermatitis. Contact Dermatitis 30:257–264
Pinnagoda J, Tupker RA, Smit JA, Coenraads PJ, Nater JP (1989) The intra- and inter-individual variability and reliability of transepidermal water loss measurements. Contact Dermatitis 21:255–259
Rietschel RL (1997) Comparison of allergic and irritant dermatitis. Immunol Allergy Clin North Am 17:359–364
Roguet R, Cohen C, Rougier A, Leclaire J (1995) Measurement of proinflammatory mediator production by cultured keratinocytes. In: Eisner P, Maibach HI (eds) Irritant dermatitis. New clinical and experimental aspects. Karger, Basel, pp 230–242
Rycroft RJG (1995) Occupational contact dermatitis. In: Rycroft RJG, Menné T, Frosch PJ (eds) Textbook of contact dermatitis. Springer, Berlin Heidelberg New York, pp 343–400
Rycroft RJG (1997) Metal working industry. Clin Dermatol 15: 565–566
Rystedt I (1985) Work-related hand eczema in atopics. Contact Dermatitis 12:164–171
Seidenari S (1996) Skin sensitivity, interindividual factors: atopy. In: van der Valk PGM, Maibach HI (eds) The irritant contact dermatitis syndrome. CRC, New York, pp 267–277
Singgih SI, Lantingha H, Nater JP, Woest TE, Kruyt-Gaspersz JA (1986) Occupational hand dermatoses in hospital cleaning personnel. Contact Dermatitis 14:14–19
Skogstad M, Levy F (1994) Occupational irritant contact dermatitis and fungal infection in construction workers. Contact Dermatitis 31:28–30
Soschin D, Kligman AM (1982) Adverse subjective reactions. In: Kligman AM, Leyden JJ (eds) Safety and efficacy of topical drugs and cosmetics. Grune and Stratton, New York, pp 377–388
Suter-Widmer J, Eisner P (1994) Age and irritation. In: van der Valk PGM, Maibach HI (eds) The Irritant contact dermatitis syndrome. CRC, Boca Raton, pp 257–261
Uter W, Gefeller O, Schwanitz HJ (1995) Occupational dermatitis in hairdressing apprentices. In: Eisner P, Maibach HI (eds) Irritant dermatitis. New clinical and experimental aspects. Karger, Basel, pp 49–55
van der Valk PGM, Maibach HI (1989) Do topical corticosteroids modulate skin irritation in human beings? Assessment by transepidermal water loss and visual scoring. J Am Acad Dermatol 21:519–522
van der Valk PGM, Nater JP, Bleumink E (1985) Vulnerability of the skin to surfactants in different groups of eczema patients and controls as measured by water vapour loss. Clin Exp Dermatol 10:98–103
van der Walle HB, Brunsveld VM (1994) Dermatitis in hairdressers. I. The experience of the past 4 years. Contact Dermatitis 30:217–221
Wahlberg JE, Maibach HI (1994) Prevention of contact dermatitis. In: Mellström GA, Wahlberg JE, Maibach HI (eds) Protective gloves for occupational use. CRC, New York, pp 7–9
Wall L, Gebauer K (1991) A follow-up study of occupational skin disease in Western Australia. Contact Dermatitis 524: 241–243
Wigger-Alberti W, Eisner P (1997) Preventive measures in contact dermatitis. Clin Dermatol 15:661–665
Wigger-Alberti W, Eisner P (1998) Do barrier creams and gloves prevent or provoke contact dermatitis? Am J Contact Dermat 9:100–106
Wigger-Alberti W, Hinnen U, Eisner P (1997) Predictive testing of metalworking fluids: a comparison of 2 cumulative human irritation models and correlation to epidemiological data. Contact Dermatitis 36:14–20
Wilhelm KP (1995) Irritant dermatitis: Experimental aspects. In: Eisner P, Maibach HI (eds) Irritant dermatitis. New clinical and experimental aspects. Karger, Basel, pp 144–151
Wilhelm KP, Surber C, Maibach HI (1989) Quantification of sodium lauryl sulphate irritant dermatitis in man: comparison of four techniques: skin color, reflectance, transepidermal water loss, laser Doppler flow measurement and visual scores. Arch Dermatol Res 281:293–295
Wilkinson JD, Willis CM (1998) Contact dermatitis: irritant. In: Champion RH, Burton JL, Burns DA, Breathnach SM (eds) Textbook of dermatology, 6th edn. Blackwell, London, PP 709–731
Williams H (1996) Relative and attributable risk and its relevance in the prevention of contact dermatitis. In: Eisner P, Lachapelle J, Wahlberg J, Maibach H (eds) Prevention of contact dermatitis. Karger, Basel, pp 10–17
Willis CM (1996) The histopathology of irritant contact dermatitis. In: van der Valk PGM, Maibach HI (eds) The irritant contact dermatitis syndrome. CRC, New York, pp 291–303
Wood BP, Greig DE (1997) Catering industry. Clin Dermatol 15:567–571
Wrangsjö K, Meding B (1997) Hospital workers. Clin Dermatol 15:573–578
Zaza S, Reeder JM, Charles LE, Jarvis WR (1994) Latex sensitivity among perioperative nurses. AORN J 60:806–812
Zugerman C (1990) Chloracne. Clinical manifestations and etiology. Dermatol Clin 8:209–213
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Wigger-Alberti, W., Elsner, P. (2000). Contact Dermatitis Due to Irritation. In: Kanerva, L., Wahlberg, J.E., Elsner, P., Maibach, H.I. (eds) Handbook of Occupational Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07677-4_11
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