Abstract
It is postulated by Jerne and his associates that a network of mutually interacting idiotypes (ids) and anti-idiotypes (anti-ids) is a major factor in regulating the immune response [1]. Analogous to the nervous system wherein an environmental stimulus becomes information as a result of setting into motion self-connected neural networks, the environmental stimulus of the immune system, the antigen, acquires meaning by impinging on self-recognizing id-anti-id networks. Although the id-anti-id hypothesis does not explain or necessitate other demonstrably important immune system factors such as MHC molecules or helper T cells, the notion has fruitfully roused the neural networks of many immunologists.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
N.K. Jerne: Ann. Immunol. (Inst. Pasteur) 125C, 373 (1974).
K. Sege, P.A. Peterson: Proc. Natl. Acad. Sci. USA 75, 2443 (1978).
Y. Schecter, R. Maron, D. Elias, I.R. Cohen: Science 216, 542 (1982).
Y. Schecter, D. Elias, R. Maron, I.R. Cohen: J. Biol. Chem. 259, 6411 (1984).
D. Elias, R. Maron, I.R. Cohen, Y. Shechter: J. Biol. Chem. 259, 6416 (1984).
I.R. Cohen, D. Elias, R. Maron, Y. Shechter: In Idiotypy in Biology and Medicine. ed. by H. Kohler, J. Urbain, P.A. Cazenave 20, 385 (Academic Press, New York, 1984).
Y. Shechter, D. Elias, R. Bruck, R. Maron, I.R. Cohen: In Anti-idiotvpes. Receptors and Molecular Mimicry. ed. by D. S. Linthicum, N.R. Farid, 73 (Springer-Verlag, 1988).
R.W. Neville, B.J. Weir, N.R. Lazarus:Diabetes 22, 851 (1973).
I.R. Cohen, D. Elias, M. Rapopport, Y. Shechter: Methods in Enzymology (in press 1989).
D. Elias, M. Rapopport, I.R. Cohen, Y. Shechter: J. Clin. Invest. 81, 1979 (1988).
D. Elias et al in preparation.
D. Elias, I.R. Cohen, Y. Shechter, Z. Spirer, A. Golander: Diabetes 36, 348 (1987).
N.H. Wassermann et al: Proc. Natl. Acad. Sci. USA 79, 4810 (1982).
G.N. Beall, B. Rapoport, I.J. Chopra, S.R. Kruger: J. Clin. Invest. 75, 1435 (1985).
S. Mendlovic, S. Brocke, Y. Shoenfeld, M. Ben-Bassat, A. Meshorer, R. Bakimer, E. Mozes: Proc. Natl. Acad. Sci. USA. 85, 2260 (1988).
M. Lugate et al: J. Clin. Endocrinol. Metab. (in press).
S.J. Yeaman et al: Lancet I, 1067 (1988).
M. Guegen et al: J. Exp. Med. 168, 801 (1988).
J.H. Shero et al: Science 231, 737 (1987).
D. Young, R. Lathigra, R. Hendrix, D. Sweetser, R.A. Young: Proc. Natl. Acad. Sci. USA 85, 4267 (1988).
W. van Eden, J. Thole, R. Van Der Zee, A. Noordzij, J.D.A. van Embden, E.J. Hensen, I.R. Cohen: Nature 331, 171 (1988).
P.C.M. Res, C.G. Schaar, F.C. Breedveld, W. van Eden, J.D.A. van Embden, I.R. Cohen, R.R.P. de Vries: The Lancet II, 478 (1988).
I.R. Cohen, H. Atlan: J. Autoimmunity, in press.
H. von Boehmer, H.S. Teh, P. Kisielow: Immunology Today 10, 57 (1989).
P.J. Bjorkman et al: Nature 329, 506 (1987).
I.R. Cohen: Immunological Rev. 94, 5 (1986).
O. Lider, E. Beraud, T. Reshef, I.R. Cohen: Science 239, 181 (1988).
I.R. Cohen, H.L. Weiner: Immunology Today 9. 322 (1988).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin, Heidelberg
About this paper
Cite this paper
Cohen, I.R. (1989). Natural Id-Anti-Id Networks and the Immunological Homunculus. In: Atlan, H., Cohen, I.R. (eds) Theories of Immune Networks. Springer Series in Synergetics, vol 46. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83935-1_2
Download citation
DOI: https://doi.org/10.1007/978-3-642-83935-1_2
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83937-5
Online ISBN: 978-3-642-83935-1
eBook Packages: Springer Book Archive