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Ex Vivo and in Vitro Models in Acetaminophen Hepatotoxicity Studies. Relationship between Glutathione Depletion, Oxidative Stress and Disturbances in Calcium Homeostasis and Energy Metabolism

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Toxicology in Transition

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 17))

Abstract

The hepatotoxicity of acetaminophen (APAP) seems to be linked to several biochemical perturbations such as glutathione depletion, oxidative stress, Ca2+ homeostasis disturbances and/or changes in energy metabolism.

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Author information

Authors and Affiliations

  1. Paris V, Faculté de Pharmacie, Laboratoire de Toxicologie, EA 207, Université René-Descartes, 4 Avenue de l’Observatoire, 75270, Paris Cedex 06, France

    S. Ellouk-Achard, V. Levresse, C. Martin, C. Pham-Huy, H. Dutertre-Catella, M. Thevenin, J.-M. Warnet & J. R. Claude

Authors
  1. S. Ellouk-Achard
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  2. V. Levresse
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  3. C. Martin
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  4. C. Pham-Huy
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  5. H. Dutertre-Catella
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  6. M. Thevenin
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  7. J.-M. Warnet
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  8. J. R. Claude
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Editor information

Editors and Affiliations

  1. Institut für Arbeitsphysiologie an der Universität Dortmund, Ardeystr. 67, D-44139, Dortmund, Germany

    Gisela H. Degen

  2. Interkantonale Kontrollstelle für Heilmittel, Erlachstr. 8, CH-3000, Bern 9, Switzerland

    Jürg P. Seiler

  3. Ciba-Geigy Ltd., K-136.3.23, CH-4002, Basel, Switzerland

    Philip Bentley

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© 1995 Springer-Verlag Berlin Heidelberg

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Ellouk-Achard, S. et al. (1995). Ex Vivo and in Vitro Models in Acetaminophen Hepatotoxicity Studies. Relationship between Glutathione Depletion, Oxidative Stress and Disturbances in Calcium Homeostasis and Energy Metabolism. In: Degen, G.H., Seiler, J.P., Bentley, P. (eds) Toxicology in Transition. Archives of Toxicology, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79451-3_18

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  • DOI: https://doi.org/10.1007/978-3-642-79451-3_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79453-7

  • Online ISBN: 978-3-642-79451-3

  • eBook Packages: Springer Book Archive

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