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Integrins and Their Ligands

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Adhesion in Leukocyte Homing and Differentiation

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 184))

Abstract

The interactions of cells with extracellular matrices is of fundamental importance in many biological processes such as embryological development would healing and the maintenance of tissue integrity. Cells adhere to the extracellular matrix via specific cell surface receptors, most of which belong to a family of structurally related glycoproteins called integrins (Hynes 1987; Ruoslahti 1987). Integrins are heterodimers composed of an α subunit noncovalently associated with a β subunit. Fourteen different a subunits and eight different β subunits have thus far been identified, forming 20 different heterodimeric complexes (Fig. 1).

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Authors and Affiliations

  1. Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

    A. Sonnenberg

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  1. A. Sonnenberg
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  1. Basel Institute for Immunology, Grenzacherstr. 487, 4005, Basel, Switzerland

    Dominique Dunon Ph.D. , Charles R. Mackay Ph.D.  & Beat A. Imhof Ph.D. ,  & 

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© 1993 Springer-Verlag Berlin · Heidelberg

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Sonnenberg, A. (1993). Integrins and Their Ligands. In: Dunon, D., Mackay, C.R., Imhof, B.A. (eds) Adhesion in Leukocyte Homing and Differentiation. Current Topics in Microbiology and Immunology, vol 184. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78253-4_2

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  • DOI: https://doi.org/10.1007/978-3-642-78253-4_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78255-8

  • Online ISBN: 978-3-642-78253-4

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