Summary
It has been recognized that, in some circumstances, brain tissues can be damaged by oxidative stress. The data presented here demonstrate that stress in animals, as well as strong emotional strain in healthy men, can initiate lipid peroxidation (LPO).
Experiments on rats have shown that activation of lipid peroxidation in the brain due to stress can be the key factor in the damage of a number of membrane-bound structures (receptors, enzymes) of the neurons from the cerebral cortex. It has also been demonstrated that the level of lipid peroxidative products significantly increased in the serum of patients with manic depressive disorders and schizophrenia. The author considers the possibility of applying antioxidants as an important component in the combined treatment of some mental disorders, as well as for the prevention of stress-induced brain damage.
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© 1992 Springer-Verlag Berlin Heidelberg
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Prilipko, L. (1992). The Possible Role of Lipid Peroxidation in the Pathophysiology of Mental Disorders. In: Packer, L., Prilipko, L., Christen, Y. (eds) Free Radicals in the Brain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77609-0_12
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DOI: https://doi.org/10.1007/978-3-642-77609-0_12
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