Abstract
Among the various radionuclides of ruthenium, 97Ru and 103Ru have proven to be quite attractive for in vitro and in vivo research investigations. Ruthenium-97, in particular, has excellent nuclear decay characteristics (t1/2 69.6 h; deday mode by electron capture; 216 keV gamma, 86%; no betas) and thus is a promising radionuclide for diagnostic imaging applications. Compared to other commonly used intermediate half-life nuclides (e.g., 67Ga, 111In), 97Ru provides marked improvement in image quality and imparts significantly less radiation dose to the patient. No-carrier-added 97Ru is routinely prepared at the Brookhaven Linac Isotope Producer (BLIP) from proton spallation of high-purity rhodium, using the 103Rh (p, 2p5n) 97Ru reaction. Ruthenium-103 (available commercially as a fission product), although not particularly appropriate for imaging, has nonetheless proven useful for chemical, in vitro, and preclinical studies.
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Srivastava, S.C., Mausner, L.F., Clarke, M.J. (1989). Radioruthenium-Labeled Compounds for Diagnostic Tumor Imaging. In: Baulieu, E., et al. Ruthenium and Other Non-Platinum Metal Complexes in Cancer Chemotherapy. Progress in Clinical Biochemistry and Medicine, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74760-1_6
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