Abstract
The effectiveness of pharmacological interventions to protect the ischaemic myocardium from irreversible injury, i.e. infarction, is a matter of controversy. While it is clear that the only effective therapeutic measure to prevent cell death is the restoration of coronary blood flow, for example by early thrombolysis, it is also evident that initially this might even aggravate the severity of cellular lesions by an inflammation-like process, originally described by Sommers and Jennings [28]. Therefore, pharmacological interventions for reducing ultimate infarct size or even preventing irreversible necrosis might be effective if they occur early after occlusion and/or improve the resistance of the injured myocardium against the two major detrimental factors: cellular calcium overload and oxygen toxicity [8, 25].
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Schrör, K., Thiemermann, C., Löbel, P. (1989). Stimulation of Vascular Prostacyclin Formation by Defibrotide: A New Strategy for Treatment of Acute Myocardial Ischaemia. In: Schmutzler, H., Rutsch, W., Dougherty, F.C. (eds) Limitation of Infarct Size. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73585-1_12
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DOI: https://doi.org/10.1007/978-3-642-73585-1_12
Publisher Name: Springer, Berlin, Heidelberg
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