Abstract
The term gene amplification refers to the selective increase of the gene copy number and is better designated as DNA amplification. It should not be confused with elevated gene expression, although amplification generally does result in enhanced levels of the products encoded by the amplified gene. Amplification is one of the mechanisms by which cells can meet the demand for synthesis of specific gene products in amounts exceeding the transcriptional capacity of a single copy gene.
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Schwab, M. (1986). Amplification of Proto-Oncogenes and Tumor Progression. In: Kahn, P., Graf, T. (eds) Oncogenes and Growth Control. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73325-3_46
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DOI: https://doi.org/10.1007/978-3-642-73325-3_46
Publisher Name: Springer, Berlin, Heidelberg
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