Abstract
The effect of mercury chloride (HgCl2) and methyl mercury chloride (MeHg) on brain synaptosomal Na+/K+-ATPase was determined in vitro. It was shown that HgC12 is a more powerful inhibitor than MeHg. The IC50 were 5 × 10−7 M for HgC12 and 2.3 × 10−6 M for MeHg. A non-competitive type of inhibition was observed with the two mercurials. Removal of contaminating lipids with the non-ionic detergent Lubrol® did not affect the inhibition of either mercurial. It is concluded that non-essential lipids do not play a significant role in the inhibitory effect of MeHg and that the potency of these mercurials on to inhibit brain synaptosomal Na+/K+-ATPase largely depends on their capacity to block sulfhydryl groups.
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© 1986 Springer-Verlag
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Magour, S. (1986). Studies on the Inhibition of Brain Synaptosomal Na+/K+-ATPase by Mercury Chloride and Methyl Mercury Chloride. In: Chambers, C.M., Chambers, P.L., Tuomisto, J. (eds) Toxic Interfaces of Neurones, Smoke and Genes. Archives of Toxicology, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71248-7_77
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DOI: https://doi.org/10.1007/978-3-642-71248-7_77
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