Abstract
Cas-Br-M is a biologically-cloned ecotropic murine leukemia virus (MuLV) isolated from wild mice of the Lake Casitas region of California (1). This virus induces both hind limb paralysis and hematopoietic neoplasms when inoculated into newborn mice (2,3). The tumors of mice inoculated with Cas-Br-M are first evident at 18–30 weeks and include T- and B-cell lymphomas, lymphoblastic lymphomas, erythroleukemias, myelogenous leukemias and megakaryocytic leukemias (4). Cas-Br-M therefore appears to be unique among murine retroviruses in its ability to cause a wide spectrum of hematopoietic tumors. The mechanisms involved in generating this range of tumors are not known, however mink lung cell focus-inducing (MCF) MuLVs may play a role since these viruses appear rapidly in the tissues of Cas-Br-M infected mice (5).
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References
Hartley, J.W., Rowe, W.P.: Naturally occurring murine leukemia viruses in wild mice: characterization of a new “amphotropic” class. J. Virol. 19, 19–25 (1976).
Gardner, M.B.: Type C viruses of wild mice: characterization and natural history of amphotropic, ecotropic, and xenotropic MuLV. Curr. Top. Microbiol. Immunol. 79, 215–259 (1978).
Gardner, M.B., Klement, V., Henderson, B.E., Casagrande, J., Bryant, M.L., Daugherty, M.F., Estes, J.D.: Lymphoma, paralysis, and oncornaviruses of wild mice. In: Tumors of Early Life in Man and Animals. Severi, L. (ed.), Perugia Quadrennial International Conferences on Cancer, Montelvce, Italy, 1978, pp. 343–356.
Fredrickson, T.N., Langdon, W.Y., Hoffman, P.M., Hartley, J.W., Morse, H.C. III: Histologic and cell surface antigen studies of hematopoietic tumors induced by Cas-Br-M murine leukemia virus. J. Natl. Cancer Inst. 72, 447–454 (] 984).
Hoffman, P.M., Davidson, W.F., Ruscetti, S.K., Chused, T.M., Morse, H.C. III: Wild mouse ecotropic murine leukemia virus infection of inbred mice: Dual-tropic virus expression precedes the onset of paralysis and lymphoma. J. Virol. 39, 597–602 (1981).
Langdon, W.Y., Hoffman, P.M., Silver, J.E., Buckler, C.E., Hartley, J.W., Ruscetti, S.K., Morse, H.C. Ill: Identification of a spleen focus-forming virus in erythroleukemic mice infected with a wild mouse ecotropic MuLV. J. Virol. 46, 230–238 (1983).
Rowe, W.P., Pugh, W.E., Hartley, J.W.: Plaque assay techniques for murine leukemia viruses. Virology 42, 1136–1139 (1970).
Hartley, J.W., Wolford, N.K., Old, L.J., Rowe, W.P.: A new class of murine leukemia virus associated with the development of spontaneous lymphomas. Proc. Natl. Acad. Sci., U.S.A. 74, 789–792 (1977).
Morse, H.C. III, Chused, T.M., Boehm-Truitt, M., Mathieson, B.J., Sharrow, S.O., Hartley, J.W.: XenCSA: Cell surface antigens related to the major glycoproteins (gp70) of xenotropic murine leukemia virus. J. Immunol. 122, 433–454 (1979).
Stroham, R.C., Moss, P.S., Micou-Eastwood, J., Spector, D., Przybyla, A., Paterson, B.: Messenger RNA from myosin polypeptides: Isolation from single myogenic cultures. Cell 10, 265–273 (1977).
Thomas, P.S.: Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc. Natl. Acad. Sci. U.S.A. 77, 5201–5205 (1980).
Hager, G.L., Chang, E.H., Chan, H.W., Garon, C.F., Israel, M.A., Scolnick, E.M., Lowy, D.R.: Molecular cloning of the Harvey sarcoma virus closed circular DNA intermediates: Initial structural and biological characterization. J. Virol. 31, 795–809 (1979).
Buckler, C.E., Hoggan, M.D., Chan, H.W., Sears, J.F., Khan, A.S., Moore, J.L., Hartley, J.W., Rowe, W.P., Martin, M.A.: Cloning and characterization of an envelope-specific probe from xenotropic murine leukemia proviral DNA. J. Virol. 41, 228–236 (1982).
Chan, H.W., Bryan, T., Moore, J.L., Staal, S.P., Rowe, W.P., Martin, M.A.: Identification of ecotropic proviral sequences in inbred mouse strains with a subgenomic DNA fragment. Proc. Natl. Acad. Sci., U.S.A. 77, 5779–5783 (1980).
Srinivasan, A., Reddy, E.P., Aaronson, S.A.: Abelson murine leukemia virus: Molecular cloning of infectious integrated proviral DNA. Proc. Natl. Acad. Sci., U.S.A. 78, 2077–2081 (1981).
Robins, T., Bister, K., Garon, C., Papas, T., Deusberg, P.: Structural relationship between a normal chicken DNA locus and the transforming gene of the avian acute leukemia virus MC29. J. Virol. 41, 63 5–642 (1982).
Perbal, B., Baluda, M.A.: Avian myeloblastosis virus transforming gene is related to unique chicken DNA regions separated by at least one intervening sequence. J. Virol. 41, 250–257 (1982).
Chang, E.H., Gonda, M.A., Ellis, R.W., Scolnick,. E.M., Lowy, D. R.: Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses. Proc. Natl. Acad. Sci., U.S.A. 79, 4848–4852 (1982).
Reddy, E.P., Smith, M.J., and Aaronson, S.A.: Complete nucleotide sequence and organization of the Moloney murine sarcoma virus genome. Science 214, 445–450 (1981).
Maniatis, T., Jeffrey, A., Kleid, D.G.: Nucleotide sequence of the rightward operator of phage λ. Proc. Natl. Acad. Sci., U.S.A. 72, 1184–1188 (1975).
Wahl, G.M., Stern, M., Stark, G.R.: Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl- paper and rapid hybridization by using dextran sulfate. Proc. Natl. Acad. Sci., U.S.A. 76, 3683–3687 (1979).
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Langdon, W.Y., Hartley, J.W., Holmes, K.L., Fredrickson, T.N., Morse, H.C. (1984). Identification of a Transforming Virus from a Lymphoma of a Mouse Infected with a Wild Mouse Retrovirus. In: Potter, M., Melchers, F., Weigert, M. (eds) Oncogenes in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 113. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69860-6_41
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DOI: https://doi.org/10.1007/978-3-642-69860-6_41
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