Abstract
Nonsteroidal anti-inflammatory compounds (NSAIDS) have been used since 1763, when Edward Stone described the therapeutic properties of an extract of willow bark upon ague. Although almost four centuries have passed since the first medical use of aspirin and more than four decades since its use for ocular conditions (Gifford 1947; for review see Sears 1974; Leopold and Murray 1979), the mechanism of the anti-inflammatory action of NSAIDS has yet to be clarified. The strong influence of these drugs on the phenomena of fever, pain, and inflammation, taken together with the known undesirable side effects of steroids, has made them of prime interest in ophthalmic therapeutics (Leopold and Murray 1979).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Abrishami MA, Thomas J (1977) Aspirin intolerance — a review. Ann Allergy 39:28
Anderson JA, Chen CC, Vita JB, Shackleton M (1982) Disposition of topical flurbiprofen in normal and aphakic rabbit eyes. Arch Ophthalmol 100:642–645
Arai Y, Shimoji K, Konno M, Konishi Y, Okuyama S, Iguchi S, Hayashi M, Miyamoto T, Toda M (1983) Synthesis and 5-lipoxygenase inhibitory activities of eicosanoid compounds. J Med Chem 26:72–78
Arnaud B (1971) The prevention of postoperative inflammation in ocular surgery by the use of Tandearil. Arch Ophthalmol (Paris) 31:349
Bhattacherjee P, Eakins KE (1974 a) Inhibition of the prostaglandin synthetase systems in ocular tissues by indomethacin. Br J Pharmacol 50:227–230
Bhattacherjee P, Eakins KE (1974 b) A comparison of the inhibitory activity of compounds on ocular prostaglandin biosynthesis. Invest Ophthalmol 13:967
Bhattacherjee P, Hammond BR, Williams RN, Eakins KE (1980) Arachidonic acid lipoxygenase products in ocular tissues and their effect on leukocyte infiltration in vivo. Proc Int Soc Eye 1:32
Bhattacherjee P, Hammond BR, Salmon J A, Stepney R, Eakins KE (1981) Chemotactic response to some arachidonic acid lipoxygenase products in the rabbit eye. Eur J Pharmacol 73:21–28
Borgeat P, Samuelsson B (1979 a) Metabolism of arachidonic acid in polymorphonuclear leukocytes: structure analysis of novel hydroxylated compounds. J Biol Chem 254:7865–7869
Borgeat P, Samuelsson B (1979 b) Arachidonic acid metabolism in polymorphonuclear leukocytes: unstable intermediate in formation of dihydroxy acids. Proc Natl Acad Sci USA 76:3213–3217
Brune K (1977) The importance of pharmacokinetics for the action of nonsteroid anti-inflammatory drugs. In: Ritshel WA (ed) Clinical pharmacokinetics, proceedings of an international sysmposium at Salzgitter-Rinzelheim (Germany). Fischer, Stuttgart, p 96
Burns CA (1968) Indomethacin, reduced retinal sensitivity, and corneal deposit. Am J Ophthalmol 66:825
Carr RE, Siegel IM (1973) Retinal function in patients treated with indomethacin. Am J Ophthalmol 75:302
Chavis RM, Uygantas CM, Uygantas A (1976) Experimental inhibition of prostaglandin-like inflammation after cryotherapy. Am J Ophthalmol 82:310
Cooper CA, Bergamini MVW, Leopold IH (1980) Use of flurbiprofen to inhibit corneal neovascularization. Arch Ophthalmol 98:1102–1105
Crawford JS, Lewandowski RL, Chan W (1975) The effect of aspirin on rebleeding in traumatic hyphema. Am J Ophthalmol 80:543–545
Crook D, Collins AJ, Rose AJ (1976) A comparison of the effects of flurbiprofen on prostaglandin synthetase from human rheumatoid synovium and enzymatically active animal tissues. J Pharm Pharmacol 28:535
Dewar AJ, Gillian B, Readin HW (1975) The effect of retinol and acetylsalicylic acid on the release of lysosomal enzymes from rat retina in vitro. Exp Eye Res 20:63
Dyster-Aas K (1973) Oxyphenbutazone eye ointment in the treatment of foreign bodies in the cornea. Acta Ophthalmol 51:791
Eakins KE (1974) Prostaglandins and prostaglandin synthetase inhibitors: actions in ocular disease: In: Robinson HJ, Vane JR (eds) Prostaglandin synthetase inhibitors. Raven, New York, p 343
Flower RJ, Blackwell GJ (1979) Anti-inflammatory steroids induce biosynthesis of a phos-pholipase A2 inhibitor which prevents prostaglandin production. Nature 278:456
Flower RJ, Vane JR (1972) Inhibition of prostaglandin synthetase in brain explains the antipyretic activity of paracetamol (4-acetamido-phenol). Nature 238:104
Fowler PD, Wildinson P (1973) Treatment of anterior uveitis, comparison of oral oxyphenbutazone and topical steroids. Br J Ophthalmol 57:892
Gieser DK, Hodapp E, Goldberg I, Kass MA, Becker B (1981) Flurbiprofen and intraocular pressure. Ann Ophthalmol 13:831–833
Gifford SR (1947) A handbook of ocular therapeutics. Lea and Febinger, Philadelphia, p 92
Goetzl EJ, Sun FF (1979) Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils. J Exp Med 150:406
Goetzl EJ, Hill HR, Gorman RR (1980) Unique aspects of the modulation of human neutrophil function by 12-L-hydroperoxy-5,8,10,14-eicosatetraenoic acid. Prostaglandins 19:71
Ham EA, Cirillo VJ, Zanetti M, Shen TY, Kuehl FA (1972) Studies on the mode of action of non-steroidal anti-inflammatory agents. In: Ramwell PW, Pharriss BB (eds) Prostaglandins in cellular biology. Plenum, New York, p 345
Hanna C, Sharp JD (1972) Ocular absorption of indomethacin by rabbit. Arch Ophthalmol 88:196–198
Hayasaka S, Masuda K, Sears ML (1981) Nonsteroid anti-inflammatory drugs stabilize the blood-aqueous barrier and lysosomal enzymes in the rabbit eye. Jpn J Ophthalmol 25:210–216
Huang K, Peyman GA, McGetrick J, Janevicius R(1977) Indomethacin inhibition of prostaglandin-mediated inflammation following intraocular surgery. Invest Ophthalmol 16:760–762
Ishii H, Sakai Y, Masuda K, Matsumura Y, Masuda K, Takase M (to be published) Nonsteroid anti-inflammatory drugs: basic studies on flurbiprofen eye drop. Jpn J Ophthalmol 25
Kass MA, Neufeld AH, Sears ML (1975) Systemic aspirin and indomethacin do not prevent the response of the monkey eye to trauma. Invest Ophthalmol 14:604–606
Katz I (1981) Indomethacin. Ophthalmology 88:455–458
Kramer SG, Oyakawa RT, Drake M (1976) Enhancement of pupillary dilation during intraocular surgery by prostaglandin inhibition. Association for research in vision and ophthalmology meeting, 25-29 April 1976, Sarasota
Kulkarni PS, Bhattacherjee P, Eakins, KE, Srinivasan BD (1981) Anti-inflammatory effects of betamethasone phosphate, dexamethasone phosphate and indomethacin on rabbit ocular inflammation induced by bovine serum albumin. Curr Eye Res 1:43
Lee RE (1974) The influence of psychotropic drugs on prostaglandin biosynthesis. Prostaglandins 5:63
Leopold IH, Murray D (1979) Noncorticosteroidal anti-inflammatory agents in ophthalmology. Ophthalmology 86:142–155
Martin NF, Green WR, Martin LW (1977) Retinal phlebitis in the Irvine-Gass syndrome. Am J Ophthalmol 83:377–386
Masuda K, Izawa Y, Mishima S (1977) Breakdown of the blood-aqueous barrier and prostaglandins. Bibl Anat 16:99
McGill JI, Easty DL, Levuy I, Holt-Wilson AD, Shilling J (1971) The etiology and treatment of marginal corneal ulcers. Trans Ophthalmol Soc UK 91:501
Miami Study Group (1979) Cystoid macular edema in aphakic and pseudophakic eyes. Am J Ophthalmol 88:45–48
Miller JD, Eakins KE, Atwal M (1973) The release of PGE2-like activity into aqueous humor after paracentesis and its prevention by aspirin. Invest Ophthalmol 12:939
Mishima S, Masuda K (1977) Clinical implication of prostaglandins and synthesis inhibitors. In: Burns RP, Leopold IH (eds) Symposium on ocular therapy, vol 10. Wiley, New York, pp 1–19
Mishima S, Masuda K (1979) Prostaglandins and the eye: a review on clinical implications. Metab Pediatr Ophthalmol 3:179
Mishima S, Masuda K, Tamura T (1977) The drugs influencing the intraocular pressure. In: Dikstein S (ed) Drugs and ocular tissues. Karger, Basel, p 128
Miyake K (1977) Prevention of cystoid macular edema after lens extraction by topical indomethacin: a preliminary report. Albrecht von Graefes Arch Klin Exp Ophthalmol 203:81–88
Miyake K (1978) Prophylaxis of aphakic cystoid macular edema using topical indomethacin. Am Intra-Ocular Implant Soc J 4:174
Miyake K, Sugiyama S, Norimatsu I, Ozawa T (1978) Prevention of macular cystoid macular edema after lens extraction by topical indomethacin (III) radio-immunoassay measurement of prostaglandins in the aqueous during and after lens extraction procedure. Albrecht von Graefes Arch Ophthalmol 209:83
Mochizuki M (1980) Transport of indomethacin in the anterior uvea of the albino rabbit. Jpn J Ophthalmol 24:363
Mochizuki M, Sawa M, Masuda K (1977) Topical indomethacin in intracapsular extraction of senile cataract. Jpn J Ophthalmol 21:215
Mortada A, Abboud I (1973) Retinal haemorrhages after prolonged use of salicylates. Brit J Ophthalmol 57:199–200
Neufeld AH, Jampol LM, Sears ML (1972) Aspirin prevents the disruption of the bloodaqueous barrier in the rabbit eye. Nature 238:158–159
Norru MS (1973) Oxyphenbutazone (Tandearil R) as an adjuvant in treatment of dendritic keratitis, double blind trial using fluorescein-rose Bengal vital staining. Acta Ophthalmol 51:591
Nozu K (1978) Flurbiprofen: highly potent inhibitor of prostaglandin synthesis. Biochimica Biophysica Acta 529:493
Palimeris G, Koliopoulos J, Velissaropoulos P (1972) Ocular side effects of indomethacin. Ophthalmologica 164:339
Perkins ES (1975) Prostaglandins and the eye. Adv Ophthalmol 29:2
Podos SM, Becker B (1976) Comparison of ocular prostaglandin synthesis inhibitors. Invest Ophthalmol 15:841–844
Podos SM, Sugar A (1980) The use of nonsteroidal anti-inflammatory drugs in ocular conditions. In: Srinivasan BD (ed) Ocular therapeutics. Masson, New York, Chap 9, pp 73–81
Podos SM, Becker B, Kass MA (1973) Indomethacin blocks arachidonic acid-induced elevation of intraocular pressure. Prostaglandins 3:7–15
Rabey JM, et al. (1977) Ophthalmoplegic migraine: amelioration by flufenamic acid, a prostaglandin inhibitor. Ophthalmologica 175:158
Sawa M, Masuda K (1976) Topical indomethacin in soft cataract aspiration. Jpn J Ophthalmol 20:514
Sears ML (1974) The use of aspirin and aspirin-like drugs in ophthalmology. In: Leopold IH (ed) Symposium on ocular therapy, vol 7. Mosby, St. Louis, Chap 10, pp 104–115
Sears ML, Neufeld AH, Jampol LM (1973) Prostaglandins. Invest Ophthalmol 12:161–164
Sears D, Sears M (1974) Blood-aqueous barrier and alpha chymotrypsin glaucoma in rabbits. Am J Ophthalmol 77:378–383
Soloway HR, Stjernschantz J, Sears ML (1981) The miotic effect of substance P on the isolated rabbit iris. Invest Ophthalmol Vis Sci 20:47–52
Stjernschantz J, Sears M, Stjernschantz L (1981) Intraocular effects of substance P in the rabbit. Invest Ophthalmol Vis Sci 20:53–60
Stone E (1763) An account of the success of the bark of the willow in the cure of agues. Philos Trans R Soc Lond 53:195
Sukamoto H (1976) Clinical use of flurbiprofen as a postoperative anti-inflammatory agent. Folia Ophthalmol Jpn 27:87
Tennant JL (1978) Prostaglandins in ophthalmology. In: Emery JM (ed) Current concepts in cataract surgery. Selected proceedings of the fifth biennial cataract congress. Mosby, St. Louis, pp 360–362
Thomas AH, Hanna C (1973) Oxyphenbutazone in ocular inflammation. Arch Ophthalmol 89:340–341
Unger WG, Cole DF, Hammond B (1975) Disruption of the blood-aqueous barrier following paracentesis in the rabbit. Exp Eye Res 20:255–270
Vane JR (1971) Inhibition of prostaglandin-synthesis as a mechanism of action for aspirin-like drugs. Nature [New Biol] 231:232
Vane JR (1976) The mode of action of aspirin and similar compounds. J Allergy Clin Immun 58:691
Watson PG, Hayreh SS, Awdry PN (1968) Episcleritis and scleritis. Br J Ophthalmol 52:348–349
Watson PG, MacKay DAR, Clement RS, Wilkinson P (1973) Treatment of episcleritis, a double blind trial comparing betamethasone 0.1 percent, oxyphenbutazone 10 percent and placebo eye ointments. Br J Ophthal 57:866–870
Williamson J, Sim AK, Chawla JC, Tham HM, Forrester JV, Mammo NV (1976) Estimation of oxyphenbutazone concentrations in human serum and aqueous humor. Eye Ear Nose Throat Mon 55:176
Woods AC (1961) Endogenous inflammation of the uveal tract. Williams and Wilkins, Baltimore, p 458
Yannuzzzi LA, Klein RM, Wallyn RH, Cohen N, Katz I (1977) ineffectiveness of indomethacin in the treatment of chronic cystoid macular edema. Am J Ophthalmol 84:517-519
Zimmerman TJ, Gravenstein N, Sugar A, Kaufman HE (1975) Aspirin stabilization of the blood-aqueous barier in the human eye. Am J Ophthalmol 79:817–819
Zimmerman TJ, Binder P, Abel RA, Kaufman H (1976) Asprin and the intraocular pressure rise following aphakic penetrating keratoplasty: a negetive report. Ann Ophthalmol 8:611–s613
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Masuda, K. (1984). Anti-Inflammatory Agents: Nonsteroidal Anti-Inflammatory Drugs. In: Sears, M.L. (eds) Pharmacology of the Eye. Handbook of Experimental Pharmacology, vol 69. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69222-2_12
Download citation
DOI: https://doi.org/10.1007/978-3-642-69222-2_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-69224-6
Online ISBN: 978-3-642-69222-2
eBook Packages: Springer Book Archive