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The Amino Acid-Induced Secretion of Glucagon

  • Chapter
Glucagon II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 66 / 2))

Abstract

An increase in the amino acid concentration in contact with pancreatic A-cells is followed by a stimulation of glucagon release. This phenomenon is observed not only in vitro at some pharmacologic concentrations of amino acid, but also in vivo, during the rise in blood amino acid which follows a protein meal. The magnitude of the A-cell secretory response is modulated by the concomitant physiologic status, i.e., mainly the plasma glucose and insulin concentrations, and by the nutritional status in the preceding days: short-term and long-term influences can modify amino acid-induced glucagon release. As a clinical consequence of this phenomenon, the administration of an amino acid, or a mixture of amino acids has become a standard functional test for exploration of A-cells in vivo as well as in vitro.

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Authors
  1. R. Assan
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  2. M. Marre
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  3. M. Gormley
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Editor information

Editors and Affiliations

  1. University of Liège, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  2. University of Brussels (V.U.B.), Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  3. Royal Academy of Medicine of Belgium, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  4. Medical Policlinics, University of Liège, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  5. Division of Diabetes, University of Liège, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  6. Institut de Médecine, Hôpital de Bavière, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

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© 1983 Springer-Verlag Berlin Heidelberg

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Assan, R., Marre, M., Gormley, M. (1983). The Amino Acid-Induced Secretion of Glucagon. In: Lefebvre, P.J. (eds) Glucagon II. Handbook of Experimental Pharmacology, vol 66 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69019-8_2

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  • DOI: https://doi.org/10.1007/978-3-642-69019-8_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69021-1

  • Online ISBN: 978-3-642-69019-8

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