Abstract
Screening for metabolic defects as a public health program should only be performed when the following premises are fulfilled:
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a)
The disease in question has serious complications or consequences.
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b)
It should have a reasonable incidence rate.
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c)
The natural course should be well known.
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d)
Treatment should be unquestionably effective with better results when the treatment is started early.
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e)
Screening methods should be reliable with almost no false negatives and few false positives necessitating recalls.
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Halvorsen, S. (1980). Screening for Disorders of Tyrosine Metabolism. In: Bickel, H., Guthrie, R., Hammersen, G. (eds) Neonatal Screening for Inborn Errors of Metabolism. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67488-4_5
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DOI: https://doi.org/10.1007/978-3-642-67488-4_5
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