Abstract
Until recently, information on anti-inflammatory agents of plant origin was sparse. The first reviews dealt primarily with the phenylbenzo-γ-pyrones (flavonoids) (Gábor, 1972 a, 1975); however, there are other substances of plant origin with antiinflammatory action. Although these are not as potent as the non-steroid antiinflammatory agents knowledge of the structure activity relationships may lead to newer and more effective preparations.
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Akhter, M.H., Sabir, M., Bhide, N.K.: Anti-inflammatory effect of berberine in rats injected locally with cholera toxin. Indian J. Med. Res. 65, 133–141 (1977)
Andersen, N.H., Ramwell,P.W.: Biological aspects of prostaglandins. Arch, intern. Med. 133, 30–50(1974)
Antal, A., Gábor, M.: UV erythema értékelésére szolgáló késziilék (Apparat für die Bewertung des UV-Erythems). Kisérl. Orvostud. 23, 478–481 (1971). Cited in: Gábor, M.: The Anti-Inflammatory Action of Flavonoids. Budapest: Akadémiai Kiadó 1972
Armentano, L., Bentsáth, A., Béres, T., Rusznyák, St., Szent-Györgyi, A.: Über den Einfluß von Substanzen der Flavongruppe auf die Permeabilität der Kapillaren. Vitamin P. Dtsch. med. Wschr. 62, 1325–1328 (1936)
Arnold, W.: Über Kamille, Pfefferminze und Fenchel. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 123, 129–159 (1927)
Arora, S., Lahiri, P.K., Sanyal, R.K.: The role of Prostaglandin E1 in inflammatory process in the rat. Int. Arch. Allergy 39, 186–191 (1970)
Ascher, P.W.: Untersuchung der Pharmakodynamik und Pharmakokinetik des Aescins am Beispiel des Hirnödems. Wien. med. Wschr. 118, 1050–1051 (1968)
Back, N., Sicuteri, F. (Eds.): Vasopeptides: Chemistry, Pharmacology, and pathophysiology. Proceedings of the Symposium on Vasopeptides. Florence, Italy, 1971. New York-London: Plenum Press 1972
Baeckeland, E., Lecomte, J.: Dérivés hydroxyetilés du rutoside isolés du rat. C.R. Soc. Biol. (Paris) 163, 2226–2229(1969)
Bartlett, G.R.: Inhibition of succinoxydase by the vitamin P-like flavonoid 2′,3,4-trihydroxy chalcone. J. Pharmacol, exp. Ther. 93, 329–337 (1948)
Beitch, B.R., Eakins, K. E.: The effects of prostaglandins on the intraocular pressure of the rabbit. Brit. J. Pharmacol. 37, 158–167 (1969)
Bogs, U., Meinhard, J.: Zur Herstellung von Kamillen-Fluidextrakt. Pharmazie 10, 653–658 (1955)
Böhm, K.: The Flavonoids. A Review of Their Physiology, Pharmacodynamics and Therapeutic Uses. Aulendorf, Württ.: Editio Cantor KG. 1968
Bonta, I.L.: Microvascular lesions as a target of anti-inflammatory and certain other drugs. Acta physiol. Pharmacol, neerl. 15, 188–222 (1969)
Breinlich, J., Scharnagel, K.: Pharmakologische Eigenschaften des EN-IN-Dizykloäthers aus Matricaria chamomilla. Arzneimittel-Forsch. 18, 429–431 (1968)
Brock, N., Kottmeier, J., Lorenz, D., Veigel, H.: Zur Frage der antiphlogistischen Wirkung von Azulenen im Tierversuch. Ein Beitrag zur Prüfungsmethodik entzündungswidriger Substanzen. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 223, 450–464 (1954)
Bundy, G., Lincoln, F., Nelson, N., Pike, J., Schneider, W.: Novel prostaglandin syntheses. Ann. N.Y. Acad. Sci. 180, 76–90 (1971)
Casley-Smith, J.R.: The actions of the benzo-pyrones on the blood-tissue-lymph-system. Folia Angiol. 24, 7–22(1976)
Casley-Smith, J., Piller, N.B.: The pathogenesis of oedemas, and the therapeutic action of coumarin and related compounds. In: Foldi, M. (Ed.): Folia angiologica Supplementa, Basic Lymphology, Second Ringelheim Symposion, Vol.III, pp.33–59. Berlin-Wien: Haupt & Koska HG. 1974
Chang, Y.-H.: Mechanism of action of colchicine. I. Effects of colchicine and its analogs on the reversed passive Arthus reaction and the carragenan-induced hindpaw edema in the rat. J. Pharmacol. exp. Ther. 194, 154–158 (1975a)
Chang, Y.-H.: Mechanism of action of colchicine. II. Effect of colchicine and its analogs on phagocytosis and Chemotaxis in vitro. J. Pharmacol. exp. Ther. 194, 159–164 (1975 b)
Chang, Y.-H.: III. Anti-inflammatory effects of colchicine compared with phenylbutazone and indomethacin. Arthritis Rheum. 18, 493–496 (1975 c)
Chaturvedi, G.N., Singh, R.H.: Experimental studies on the anti-arthritic effect of certain indigenous drugs. Indian J. med. Res. 53, 71–80 (1965)
Chaturvedi, A.K., Parmar, S.S., Bhatnagar, S.C., Misra, G., Nikam, S.K.: Anticonvulsant and anti-inflammatory activity of natural plant coumarins and triterpenoids. Res. Commun, chem. path. Pharmacol. 9, 11–22 (1974)
Chaturvedi, A.K., Parmar, S.S., Nigam, S.K., Bhatnagar, S.C., Misra, G., Sastry, B.V.R.: Anti-inflammatory and anticonvulsant properties of some natural plant triterpenoids. Pharmacol. Res. Commun. 8, 199–210 (1976)
Chau, T.T., Haley, T.J.: Flavonoid antagonism of the spasmogenic effect of angiotensin, bradykinin and eledoisin of guinea pig ileum. J. pharm. Sci. 58, 621–623 (1969)
Chayen, J., Bitensky, L.: Lysosomal enzymes and inflammation with particular reference to rheumatoid diseases. Ann. rheum. Dis. 30, 333–405 (1969)
Chevillard, L., Ranson, M., Senault, B.: Activité anti-inflammatoire d’extraits de fragon épineux (Ruscus aculeatus L.). Méd. Pharmacol. exp. 12, 109–114 (1965)
Courbat, P.: Quelques généralités sur les composés flavonoïdes. In: Clinical Pharmacology: Flavonoids and vascular wall. Symposia angiologica Santoriana, 4 th International Symposium, Fribourg-Nyon, 1972, pp.3–29. Basel-München-Paris-London-New York-Sydney: S. Karger 1972
Courbat, P., Favre, J., Guerne, R., Uhlmann, G.: Contribution à l’étude d’un produit de β-hydro-xyéthylation du rutoside. Partie 1. Isolement et identification des constituants majeurs par Chromatographie sur papier. Helv. chim. Acta 49, 1203–1211 (1966 a)
Courbat, P., Uhlmann, G., Guerne, R.: Contribution à l’étude d’un produit de β-hydroxyéthylation du rutoside. Identification des constituants majeurs par spectrophotométrie ultraviolette. Helv. chim. Acta 49, 1420–1424 (1966 b)
Crutchley, D.J., Piper, P.J.: Inhibition of the inactivation of prostaglandins in guinea pig lungs. Naunyn-Schmiedebergs Arch. Pharmacol. 279, 27 (1973)
Dale, H.H., Laidlaw, P.P.: The physiological action of β-iminazolylethylamine. J. Physiol. (Lond.) 41, 318–344(1910)
D’Arcy, P.F, Kellett, D.N.: Glycyrrhetinic acid. Brit. med. J. 1, 647 (1957)
Dean, F.M.: Naturally occuring oxygen ring compounds. London: Butterworths 1963
Denko, C.W., Whitehouse, M.W.: Effects of colchicine in rats with urate crystal-induced inflammation. Pharmacology (Basel) 3, 229–242 (1970)
Dhawan, B.N., Srimal, R.C: Anti-inflammatory and some other pharmacological effects of 3,4-trans–2,2-dimethyl-3-phenyl-4-[p-(β-pyrrolidinoethoxy)-phenyl]-7-methoxy-chroman (Centchroman) Brit. J. Pharmacol. 49, 64–73 (1973)
Diczfalusy, E., Fernö, O., Fex, H., Högberg, B., Linderot, T., Rosenberg, Th.: Synthetic high molecular weight enzyme inhibitors. I. Polymeric phosphates of phloretin and related compounds. Acta chem. scand. 7, 913–920 (1953)
Dingle, J.T., Fell, H.B. (Eds.): Lysosomes in Biology and Pathology. Amsterdam: North-Holland 1969
Doll, R., Hill, I.D., Hutton, C., Underwood, D.J.: Clinical trial of a triterpenoid liquorice compound in gastric and duodenal ulcer. Lancet II, 793 (1962)
Eakins, K.E.: Prostaglandin antagonism by polymeric phosphates of phloretin and related compounds. Ann. N.Y. Acad. Sci. 180, 386–395 (1971)
Eakins, K. E., Karim, S. M. M.: Polyphloretinphosphate–a selective antagonist for prostaglandin F1α and F2αLife Sci. 9, 1–5 (1970)
Eakins, K.E., Karim, S.M.M., Miller, J.D.: Antagonism of some smooth muscle reactions of prostaglandins by polyphloretin phosphate—a selective antagonist for prostaglandins F1α and F2α. Life Sci. 9, 1–5 (1970)
Eakins, K.E., Miller, J.D., Karim, M.M.: The nature of the prostaglandin-blocking activity of polyphloretin phosphate. J. Pharmacol. exp. Ther. 176, 441–447 (1971)
Eakins, K.E., Sanner, J.H.: Prostaglandin antagonists. In: Karim, S.M.M. (Ed.): The Prostaglandins, pp.263–292. New York: Wiley-Interscience 1972
Erdös, E.G.: Effect of nonsteroidal anti-inflammatory drugs in endotoxin shock. Biochem. Pharmacol. Suppl., 283–291 (1968)
Erspamer, V. (Ed.): 5-Hydroxytryptamine and Related Indolealkylamines. Handbook experimental Pharmakology. Berlin-Heidelberg-New York: Springer 1966
Farkas, L., Gábor, M., Kallay, F. (Eds.): Topics in Flavonoid Chemistry and Biochemistry. Proceedings of the Fourth Hungarian Bioflavonoid Symposium Keszthely, 1973. Budapest: Akadémiai Kiadö 1975
Fassbender, H.G., Pippert, H.K.: Die allergisch-hyperergische Entzündung von Haut und Gelenken unter dem Einfluß von Hyaluronidase und Rutin. Z. ges. exp. Med. 123, 210–218 (1954)
Felix, W.: Wirkungsmechanismus der internen Therapie mit „Venopharmaka“. Dtsch. med. Wschr. 21, 456–466 (1970)
Feuer, G.: The metabolism and biological actions of Coumarins. In: Ellis, G.P., West, G.B. (Eds.): Progress in Medicinal Chemistry, Vol. 10, pp.85–158. Amsterdam-London: North-Holland 1974
Finney, R.S.H., Somers, G.F.: The anti-inflammatory activity of glycyrrhetinic acid and derivatives. J. Pharm. (Lond.) 10, 613–620 (1958)
Finney, R.S.H., Tarnoky, A.L.: The pharmacological properties of glycyrrhetinic acid hydrogen succinate (disodium salt). J. Pharm. (Lond.) 12, 49–58 (1960)
Fitzgerald, T.J., Williams, B., Uyeki, E.H.: Colchicine on sodium urate-induced paw swelling in mice: structure-activity relationships of colchicine derivatives. Proc. Soc. exp. Biol. (N.Y.) 136, 115–120(1971)
Flower, R.J.: Drugs which inhibit prostaglandin biosynthesis. Pharmacol. Rev. 26, 33–67 (1974)
Földi, M., Zoltán, Ö.T.: Experimentelle Thrombophlebitis und deren therapeutische Beeinflussung. Arzneimittel-Forsch. 15, 901–903 (1965)
Földi, M., Zoltán, Ö.T., Piukovich, I.: Die Wirkung von Rutin und Cumarin auf den Verlauf einer experimentellen Thrombophlebitis. Arzneimittel-Forsch. 20, 1629–1635 (1970)
Földi-Börcsök, E.: Effect of external lymph drainage and of coumarin treatment injury in the rat hind leg. Brit. J. Pharmacol. 46, 254–259 (1972)
Földi-Börcsök, E., Bedall, F.K., Rahlfs, V.W.: Die antiphlogistische und ödemhemmende Wirkung von Cumarin aus Melilotus officinalis. Arzneimittel-Forsch. 21, 2025–2030 (1971)
Fontaine, L., Grand, M., Molho, D., Boschetti, E.: Activité anti-inflammatoire expérimentale de coumarins, indane-diones et acyl-indan-diones apparentées aux anticoagulants oraux. Méd. Pharmacol. exp. 17, 497–507 (1967)
Formanek, K., Holler, H.: Über den Einfluß von Trioxyäthylrutin auf das experimentell erzeugte Ödem der Rattenpfote. Wien. med. Wschr. 110, 697–699 (1960)
Fries, B.: The edema-inhibiting action of polyphloretin-phosphate (PPP) in some types of capillary damage. An experimental investigation. Acta chir. scand. 119, 1–7 (1960)
Frimmer, M.: Biochemie und Pathophysiologie von Entzündungsmediatoren. Int. Z. klin. Pharmakol. Ther. Toxikol. 2, 144–151 (1971)
Gábor, M.: The Anti-Inflammatory Action of Flavonoids. Budapest: Akadémiai Kiadó 1972a
Gábor, M.: Pharmacologie effects of flavonoids on blood vessels. In: Comèl, M., Laszt, L. (Eds.): Clinical Pharmacology: Flavonoids and Vascular Wall. Symposia angiologica santoriana. 4 th International Symposium, Fribourg-Nyon 1972. Basel-München-Paris-London-New York-Sydney: Karger 1972b
Gabor, M.: Influence of flavonoids on decrease of capillary resistance in inflammation caused by red paprika (Capsicum annuum L. Solanaceae). In: Gábor, M.: The Anti-Inflammatory Action of Flavonoids, pp.78–83. Budapest: Akadémiai Kiadó 1972 c
Gábor, M.: Pathophysiology and Pharmacology of Capillary Resistance. Budapest: Akadémiai Kiadó 1974
Gábor, M.: Abriß der Pharmakologie von Flavonoiden unter besonderer Berücksichtigung der antiödematösen und antiphlogistischen Effekte. Budapest: Akadémiai Kiadó 1975
Gábor, M., Antal, A.: Influence of O-(β-hydroxyethyl)rutin on erythema induced by UV radiation. In: Gábor, M.: The Anti-Inflammatory Action of Flavonoids, pp.84–93. Akadémiai Kiadó 1972
Gábor, M., Blazsö, G.: In: Gábor, M.: Abriß der Pharmakologie von Flavonoiden, unter besonderer Berücksichtigung der antiödematösen und antiphlogistischen Effekte. Budapest: Akadémiai Kiadö 1975
Gábor, M., Iván, J.: Effect of O-(β-hydroxyethyl)rutin on the oedema-preventing action of butazolidin. In: Gábor, M.: The Anti-Inflammatory Action of Flavonoids, pp.94–100. Budapest: Akadémiai Kiadó 1972
Gábor, M., Szórády, J.: Die Beeinflussung der experimentellen Senfölentzündungen mit Hematoxylin. Acta physiol. Acad. Sci. hung. 3, 405–407 (1952)
Gábor, M., Szórády, I., Dirner, Z.: The inhibiting effect of the members of the haematoxylin group on the action of histidin-decarboxylase. Acta physiol. Acad. Sci. hung. 3, 595–600 (1952)
Ganesan, P.A., Karim, S.M.M.: Polyphloretin phosphate temporarily potentiates prostaglandin E2 on the rat fundus, probably by inhibiting PG-15-hydroxyde-hydrogenase. J. Pharm. (Lond.) 25, 229–233(1973)
Garcia Lerne, J., Walaszek, E.J.: Antagonists of pharmacologically active peptides: effect on guinea pig ileum and inflammation. Pharmacologist 9, 242 (1967)
Garcia Lerne, J., Walaszek, E.J.: Antagonists of pharmacologically active peptides. Effect on guinea pig ileum and inflammation. Pharmacology and the Future of Man, Proceedings 5 th International Congr. Pharmacology, San Francisco 1972. Basel: Karger 1973, Vol.V, pp.328–335
Garattini, S., Valzelli, L.: Serotonin. Amsterdam-London-New York: Elsevier 1965
Gascon, A.L., Walaszek, E.J.: Inhibition of valyl5 angiotensinamide II by osajin. J. Pharm. (Lond.) 18, 478–479 (1966)
Gecse, Á., Zsilinszky, N., Horpácsy, G., Gabor, M.: Data on the mechanism of the anti-inflammatory effect of flavonoids. In: Gábor, M.: The Anti-Inflammatory Action of Flavonoids. Budapest: Akadémiai Kiadó 1972
Geissman, T.A.: The Chemistry of Flavonoid Compounds. Oxford-London-New York-Paris: Pergamon Press 1962
Goldyne, M.E.: Prostaglandins and cutaneous inflammation. J. invest. Derm. 64, 377–385 (1975)
Goodman, L.S., Gilman, A.: The pharmacological basis of therapeutics, 4 th ed. London: McMillan 1971
Gözsi, B., Kátó, L.: Balancing Mechanisms in Acute Inflammation. Montreal: Thérien Frères 1970
Griffith, J.G.Jr., Krewson, Ch. F., Naghski, J.: Rutin and Related Flavonoids. Chemistry—Pharmacology-Clinical applications. Easton, Pa.: Mack Publ. Co. 1955
Gross, F.: Unspezifische Beeinflussung entzündlicher Reaktionen. Schweiz. med. Wschr. 80, 697–701 (1950a)
Gross, F.: Zur Auslösung und Beeinflussung der Oedembildung nach Injektion von Hühnereiweiß an der Ratte. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 211, 421–426 (1950 b)
Gross, F., Meier, R.: Die Wirkung von synthetischen Antihistaminkörpern auf die Senfölchemosis am Kaninchenauge. Experientia (Basel) 4, 400–402 (1948)
Gugler, R., Dengler, H.J.: Inhibition of human liver catechol-O-methyltransferase. Naunyn-Schmiedebergs Arch. Pharmakol. 276, 223–233 (1973)
Gujral, M.L., Sareen, K., Tangri, K.K., Amma, M.K.P., Roy, A.K.: Anti-arthritic and anti-inflammatory activity of gum guggul (Balsamodendron mukul Hook). Ind. J. Physiol. Pharmacol. 4, 267–273 (1960)
Gupta, M.B., Bhalla, T.N., Gupta, G.P., Mitra, C.R., Bhargava, K.P.: Anti-inflammatory activity of natural products. I. Triterpenoids. Eur. J. Pharmacol. 6, 67–70 (1969)
Gupta, M.B., Bhalla, T.N., Gupta, G.P., Mitra, C.R., Bhargava, K.P.: Anti-inflammatory activity of taxifolin. Jap. J. Pharmacol. 21, 377–382 (1971)
Gupta, M.B., Bhalla, T.N., Tangri, K.K., Bhargava, K.P.: Biochemical study of the anti-inflammatory activity of α- and β-amyrin acetate. Biochem. Pharmacol. 20, 401–405 (1971)
Haagen-Smit, A. J.: Azulenes. In: Progress in the Chemistry of Organic Natural Products. Zechmeister, L. (Ed.). Wien: Springer-Verlag 1948, pp.40–71
Hammersen, F.: The fine structure of different types of experimental edemas for testing the effect of vasoactive drugs demonstrated with a flavonoid. In: Comèl, M., Laszt, L. (Eds.): Clinical Pharmacology: Flavonoids and Vascular wall. Symposia angiologica santoriana. 4th. International Symposium, Fribourg-Nyon 1972, pp.194–222. Basel-München-Paris-London-New York-Sydney: Karger 1972
Hammersen, F., Möhring, E.: Der Feinbau der Endstrombahn beim Dextran-Ödem und deren Beeinflussung durch HR. Fortschr. Med. 86, 925–927 (1968)
Hammersen, F., Möhring, E.: Das Dextran-Ödem der Ratte als morphologisches Modell zur Prüfung gefäßaktiver Pharmaka. Dtsch. med. Wschr. 21, 472–478 (1970)
Hammersen, F., Möhring, E.: Zum Feinbau enzymatisch bedingter Endothel- und Erythrozytenveränderungen (Phospholipase-Ödem) und deren Beeinflussung durch HR. Dtsch. med. Wschr. 23, 406–409 (1972)
Hansel, R., Rimpler, H., Walther, K.: Ein lipophiles Flavon aus der Kamille (Matricaria chamomilla L.). Naturwissenschaften 53, 19 (1966)
Harborne, J.B.: Comparative Biochemistry of the Flavonoids. London-New York: Academic Press 1967
Harborne, J.B., Mabry, T. J., Mabry, Y.H., Eds.: The Flavonoids. London: Chapman & Hall 1975
Hava, M., Janku, L: The pharmacology of camomile and juniper. Rev. Czech. Med. 3, 1–9 (1957)
Heubner, W., Albath, W.: Über die entzündungswidrige Wirkung des Rein-Azulens aus Matricaria chamomilla L. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 192, 383–388 (1939)
Heubner, W., Grabe, F.: Über die entzündungswidrige Wirkung des Kamillenöls. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 171, 329–339 (1933)
Hikino, H., Taguchi, T., Fujimura, H., Hiramatsu, Y.: Antiinflammatory principles of Caesalpinia sappan wood and of Haematoxylon Campechianum wood. Planta Med. 31, 214–220 (1977)
Hopf, G., Kaessmann, H.J., Pekker, I., Schäfer, E.A., Weber, H.G.: Experimentelle Untersuchungen der Beeinflussung des postoperativen Extremitätenödems am Hunde mit einem Cumarin-Präparat. Arzneimittel-Forsch. 21, 854–855 (1971)
Hörhammer, L., Wagner, H., Salfner, B.: Neue Flavonglykoside aus der Kamille (Matricaria chamomilla L.). 3. Mitteilung über Compositen- und Papilionaceenflavone. Arzneimittel-Forsch. 13, 33–36 (1963)
Horton, E.W.: Prostaglandins. Berlin-Heidelberg-New York: Springer Verlag 1972
Isaac, O.: Fortschritte in der Kamillenforschung. Dtsch. Apoth.-Ztg. 114, 255–260 (1974)
Isaac, O., Schimpke, H.: Alte und neue Erkenntnisse der Kamillenforschung. Mitt. dtsch. pharm. Ges. 35, 133–147, 157–170(1965)
Jakovlev, V., Schlichtegroll, A.: Zur entzündungshemmenden Wirkung von (-)-α-Bisabolol, einem wesentlichen Bestandteil des Kamillenöls. Arzneimittel-Forsch. 19, 615–616 (1969)
Jancsó, M.: Histamin: A reticulo-endotheliális sejtrendszer élettani aktivátora (Histamine, the biological activator of the reticuloendothelial cell system). Orv. Lapja 3, 1025–1030 (1947 a)
Jancso, N.: Histamine as a physiological activator of the reticuloendothelial system. Nature (Lond.) 160, 227–228 (1947 b)
Jancsó, M.: Idegi mechanizmusok szerepe a gyulladá sban. Orv. Hetil. 106, 289–296 (1965)
Jeličić-Hadžović, J., Stern, P.: Azulene und Bradykinin. Arzneimittel-Forsch. 22, 1210–1211 (1972)
Kaley, G., Weiner, R.: Prostaglandin E1: a potential mediator. Ann. N.Y. Acad. Sci. 180, 338–350 (1970)
Karim, S.M.M., Ed.: The Prostaglandins. New York: Wiley — Interscience 1972
Kátó, L., Gözsy, L.: Effets vasculaires des bioflavonoïdes chez le rat. Vie méd. 50, 33–42 (1969)
Kellner, M., Kovách, A.G.B., Földi, M.: Über die antiphlogistische Wirkung des Melilotusex-traktes Esberiven. Arzneimittel-Forsch. 15, 326–328 (1961)
Khadzay, Ya.I.: Biological properties and pharmacological activity of coumarins and furocumarins. Akad. Nauk SSSR, Ser.5, Rast. Syr’e 12, 25–30 (1965). See Chem. Abst. 64, 1185d
Khadzay, Ya.I., Obolentseva, G.V., Serdyuk, A.D.: On the pharmacology of acacetine. Farmakol. i Toksikol. 32, 451–453 (1969)
König, H.: Zur Chemie der Prostaglandine-Biogenese, Stoffwechsel, Totalsynthese. Klin. Wschr. 53, 1041–1048 (1975)
Koshland, D.E. Jr.: Conformation changes at the active site during enzyme action. Fed. Proc. 23, 719–726(1964)
Kraus, S.D.: Glycyrrhetinic acid—a triterpene with antioestrogenic and anti-inflammatory activity. J. Pharm. (Lond.) 12, 300–306 (1960)
Kristen, G., Schmidt, W.: Kamille und Azulene. Pharmakologie — Therapie — Galenik. Mitt, dtsch. pharm. Ges. 27, 105–114 (1957)
Küchle, H.J., Wegener, H.: Quantitative Untersuchungen über Wirksamkeit und Wirkungsstärke entzündungshemmender Substanzen. Z. ges. exp. Med. 118, 136–142 (1951)
Kuznecova, G.A.: Naturally oecuring coumarins and furocoumarins. Nauka 1967
Lavollay, J., Neumann, J.: Les substances actives contre la fragilité vasculaire. Expos. ann. Biochim. méd. 10, 59 (1949)
Lecomte, J.: Pouvoir amino-libérateur des bioflavonoïdes chez le rat. C.R. Soc. Biol. (Paris) 165, 433–435(1971)
Lecomte, J., Van Cauwenberge, H.: Le pouvoir amino-libérateur du quelques bioflavonoïdes chez le rat. In: Comèl, M., Laszt, L. (Eds.): Clinical Pharmacology: Flavonoids and Vascular Wall. Symposia angiologica santoriana, 4 th International Symposium, pp.179–193. Fribourg-Nyon 1972, Basel-München-Paris-London-New York-Sydney: Karger 1972
Lecomte, J., Van Cauwenberge, H.: Sur quelques propriétés pharmacologiques du mono (O.β.hydroxy éthyl) 7 rutoside chez le rat. Arch. int. Pharmacodyn. 208, 317–327 (1974)
Lespagnol, A., Lespagnol, Ch., Lesieur, D., Cazin, J.Cl., Cazin, M., Beerens, H., Romond, Ch.: Activités analgésique, antiinflammatoire et antimicrobienne des chalcones et dihydrochalcones dérivées de l’acide salicylique. Bull. Chim. thér. 365–369 (1972)
Leuschner, F.: Über die perkutane Beeinflussung von experimentellen Ödemen und Gewebsschäden bei Ratten. 2nd Czechoslovak Congress of Internal Medicine; Pathogenesis and Therapy in Edema, Bratislava 1970
Leuschner, F., Leuschner, A.: Über die perkutane Beeinflussung von experimentellen. Ödemen und Gewebeschäden bei Ratten. 56, 612–618 (1972)
Lewis, G.P.: Kinins in inflammation and tissue injury. In: Bradykinin, Kallidin and Kallikrein. In: Erdös, E.G. (Ed.): Handbook of Experimental Pharmacology. Berlin-Heidelberg-New York: Springer Verlag 1970, Vol. XXV, pp. 516–530
Lietti, A., Cristoni, A., Picci, M.: Studies on Vaccinium myrtillus anthocyanosides. I. Vasoprotective and antiinflammatory activity. Arzneimittel-Forsch. Drug Res. 26, 829–832 (1976)
Linde, H., Cramer, G.: (-)-α-Bisabolol and cis-2-[Hexadim-(2,4)-yliden]-l,6-dioxaspiro-[4,4]-no-nen-(3) in handelsüblichen Kamillen-Extrakten. Arzneimittel-Forsch. 22, 583–585 (1972)
Logeman, W., Lauria, F., Tosolini, G.: Über Ketole der 18α- und 18β-Glycyrrhetinsäure. Chem. Ber. 90, 601–604(1957)
Lorenz, W., Kusche, J., Barth, H., Mathias, Ch.: Action of several flavonoids on enzymes of histamine metabolism in vitro. In: Histamine. Mechanisms of Regulation of the Biogenic Amines Level in the Tissues With Special Reference to Histamine, Proceedings of Satellite Symposium of the XXVth International Congress of Physiological Sciences, Łodź, Poland 1971, Maslinśki, C. (Ed.)., pp.265–269, Stroudsburg, Penn.: Dowden, Hutchinson & Ross Inc. 1973
Lorenz, D., Marek, M.L.: Das therapeutisch wirksame Prinzip der Roßkastanie (Aesculus hippocastanum). 1. Mitt.: Aufklärung des Wirkstoffes. Arzneimittel-Forsch. 10, 263–272 (1960)
Lorenz, D., Reiffer, F.: Die oedemhemmende Wirksamkeit von Aescin und Buphenin bei cutaner Anwendung am Kaolin-Oedem der Rattenpfote. Arzneimittel-Forsch. 17, 1083–1084 (1967)
Makarov, V.A., Khadzai, Ya.I.: Antiphlogistic and P-vitaminogenic activity of blackthorn flavonols. Farmakol. i Toksikol. 32, 438–441 (1969)
Malawista, S.E.: Colchicine: a common mechanism for its anti-inflammatory and anti-mitotic effects. Arthr. Rheum. 11, 191–197 (1968)
Marrazzi, M.A., Matschinsky, F.M.: Properties of 15-hydroxyprostaglandin dehydrogenase: structural requirements for substrate binding. Prostaglandins 1, 373–388 (1972)
Martin, G.J., Brendel, R., Beiler, J.M.: Effects of parenterally administered trypsin and phosphorylated hesperidin. Arch. int. Pharmacodyn. 96, 124–129 (1953)
Martin, G.J., Graff, M., Brendel, R., Beiler, J.M.: Effect of vitamin P compounds on the action of histidine decarboxylase. Arch. Biochem. 21, 177–180 (1949)
Maslinsky, C., Ed.: Histamine. Mechanisms of Regulation of the Biogenic Amines Level in the Tissues With Special Reference to Histamine, Proceedings Satellite Symposium of the XXVth International Congress of Physiological Sciences, Łódź, Poland 1971. Stroudsburg, Penn.: Dowden, Hutchinson & Ross Inc. 1973
Menkin, V.: Effect of adrenal cortex extract on capillary permeability. Amer. J. Physiol. 129, 691–697(1940)
Menkin, V.: Anti-inflammatory activity of some water-soluble bioflavonoids. Amer. J. Physiol. 196, 1205–1210(1959)
Meyer, R., Schuler, W., Desaulles, P.: Zur Frage des Mechanismus der Hemmung des Bindege-webswachstums durch Cortisone. Experientia (Basel) 6, 469–471 (1950)
Mirkovitch, V., Borgeaud, J., Meyer, S., Niebes, P.: Prévention de thrombose expérimentale par O-(β-hydroxyéthyl)-rutosides. Helv. chir. Acta 39, 379–382 (1972)
Niebes, P.: Influence des flavonoïdes sur la métabolisme des mucopolysaccharides dans la paroi veineuse. In: Comèl, M., Laszt, L. (Eds.): Symposia Angiologica Santoriana, 4th International Symposium, Fribourg-Nyon, Clinical Pharmacology: Flavonoids and Vascular Wall, pp. 94–102. Basel-München-Paris-New York-Sydney: Karger 1972
Niebes, P., Ponard, G.: Stabilization of rat liver lysosomes by (+)-cyanidanol-3 in vivo. Biochem. Pharmacol. 24, 905–909 (1975)
Northover, B.J., Subramanian, G.: A study of possible mediators of inflammatory reactions in the mouse foot. Brit. J. Pharmacol. 18, 346–355 (1962)
Oettel, H., Wilhelm-Kollmansperger, G.: Zur Frage der antiphlogistischen Wirkung von Azulenen. I. Mitteilung. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 226, 473–485 (1955)
Oettel, H., Wilhelm-Kollmansperger, G.: Zur Frage der antiphlogistischen Wirkung von Azulenen. II. Mitteilung. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 228, 331–339 (1956)
Park, M.K., Dyer, D.C.: Effect of polyphloretinphosphate and 7-oxa-13 prostynoic acid on the vasoactive actions of prostaglandin E2 and 5-hydroxytryptamine on isolated human umbilical arteries. Prostaglandins 3, 913–920 (1973)
Parmar, N.S., Ghosh, M.N.: Some pharmacological studies of bioflavonoids in rats. Bull. Jipmer clin. Soc.10, 183–190(1974)
Pastan, J., Almqvist, S.: Purification and properties of mast cell protease. J. biol. Chem. 241, 5090–5094 (1966)
Patt, P., Winkler, W.: Das therapeutisch wirksame Prinzip der Roßkastanie (Aesculus hippocastanum). 2. Mitt: Zur Chemie des Wirkstoffes. Arzneimittel-Forsch. 10, 273–275 (1960)
Piller, N.B.: The resolution of thermal oedema at various temperatures under coumarin treatment. Brit. J. exp. Path. 56, 83–91 (1975)
Piller, N.B.: An integration of the modes of action of coumarin. An explanation of its effectiveness as a therapy for thermally injured tissue. Arzneimittel-Forsch. (Drug Res.) 27, 1135–1138 (1977 a)
Piller, N.B.: Benzopyrone treatment of mild thermal oedema: determination of the most effective doses. Arzneimittel-Forsch. (Drug Res.) 27, 1138–1141 (1977b)
Poethke, W., Bulin, P.: Phytochemische Untersuchung einer neue gezüchteten Kamillensorte. 1. Mitt.: Flavonglykoside und Cumarinderivate. Pharm. Zentralh. 108, 733–746 (1969a)
Poethke, W., Bulin, P.: Phytochemische Untersuchung einer neu gezüchteten Kamillensorte. 2. Mitt.: Ätherisches Öl. Pharm. Zentralh. 108, 813–823 (1969b)
Preziosi, P., Manca, P.: Die Antiödem- und die antiinflammatorische Wirkung von Aescin und ihre Beziehung zur Hypophysen-Nebennieren-Achse. Arzneimittel-Forsch. 15, 404–413 (1965)
Radouco-Thomas, S., Grumbach, P., Nosal, Gl., Radouco-Thomas, C.: Anti-inflammatory effect of trihydroxyethylrutoside assessed in the granuloma pouch. Life Sci. 3, 459–464 (1964)
Ramaswamy, A.S.: Pharmacological action of the biflavonoids from the Gymnosperms with special reference to Ginkgo biloba L. J. med. Ass. 55, 163–165 (1970)
Ramwell, P.W., (Ed.): The Prostaglandins. New York-London: Plenum Press 1973
Ramwell, P., Shaw, J.E., (Eds.): Prostaglandins. Ann. N.Y. Acad. Sci. 180, 1971
Riesterer, L., Jaques, R.: The influence of anti-inflammatory drugs on the development of an experimental traumatic paw oedema in the rat. Pharmacology (Basel) 3, 243–251 (1970)
Rocha e Silva, M.: Histamine. Its Role in Anaphylaxis and Allergy. Springfield, Illinois: Charles C. Thomas 1955
Rocha e Silva, M. (Ed.): Histamine and Anti-Histaminics, Handbook of Experimental Pharmacology. Berlin-Heidelberg-New York: Springer 1966, Vol. XVIII/1
Rocha e Silva, M., Garcia Lerne, J.: Chemical Mediators of the Acute Inflammatory Reaction. Oxford-New York: Pergamon Press 1972
Rothkopf, M., Vogel, G.: Neue Befunde zur Wirksamkeit und zum Wirkungsmechanismus des Roßkastaniensaponins Aescin. Arzneimittel-Forsch. (Drug Res.) 26, 225–235 (1976)
Salgado, E., Green, D.M.: Action of bioflavonoids on inflammation. J. appl. Physiol. 8, 647–650 (1955)
Samuelsson, B., Paoletti, R. (Eds.): Advances in Prostaglandin and Thromboxane Research. New York: Raven Press 1976
Schilcher, H.: Neuere Erkenntnisse bei der Qualitätsbeurteilung von Kamillenblüten bzw. Kamillenöl. Teil 1: Quantitative Gehaltsbestimmung des ätherischen Öles in Flores Chamomillae. Dtsch. Apoth.-Ztg. 112, 1497–1500 (1972)
Schilcher, H.: Neuere Erkenntnisse bei der Qualitätsbeurteilung von Kamillenblüten bzw. Ka-millenöl. Teil 2: Qualitative Beurteilung des ätherischen Öles in Flores Chamomillae. Planta med. 23, 132–144(1973)
Schwabe, K.-P., Flohé, L.: Catechol-O-Methyltransferase, III. Beziehungen zwischen der Struktur von Flavonoiden und deren Eignung als Inhibitoren der Catechol-O-Methyltransferase. Hoppe-Seylers Z. physiol. Chem. 353, 476–482 (1972)
Selye, H.: Use of “Granuloma Pouch” technique in the study of antiphlogistic corticosteroids. Proc. Soc. exp. Biol. (N.Y.) 82, 328–333 (1953)
Sharma, J.N., Sharma,J.N.: Comparison of the anti-inflammatory activity of Commiphora mukul, an indigenous drug, with those of phenylbutazone and ibuprofen in experimental arthritis induced by mycobacterial adjuvant. Arzneimittel-Forsch. (Drug Res.) 27, 1455–1457 (1977)
Shils, M.E., Goodhart, R.S.: The Flavonoids in Biology and Medicine. A Critical Review. New York: The National Vitamin Foundation 1956
Shimamoto, K., Takaori, S.: Pharmakologische Untersuchungen mit einem Melilotus-Extrakt. Arzneimittel-Forsch. 15, 897–899 (1965)
Sokoloff, B., Eddy, W.H., Redd, J.B.: The biological activity of a flavonoid (Vitamin “P”) compound. J. clin. Invest. 30, 395–400 (1951)
Somers, G.F.: Glycyrrhetinic acid. Brit. med. J. I, 463 (1957)
Southern, E. M., Ed.: The Prostaglandins. Clinical Applications in Human Reproduction. Mount Kisco, New York: Futura Publ. Co. Inc. 1972
Spector, W.G., Willoughby, D.A.: Chemical mediators. In: The Inflammatory Process, Zweifach, B.W., Grant, L., McCluskey, R.T. (Eds.). New York-London: Academic Press 1965, pp. 427–448
Spector, W.G., Willoughby, D.A.: The Pharmacology of Inflammation. London: English Universities Press 1968
Stern, P.: Antiallergische Wirkung der Azulene. In: Premier Congrês International d’Allergie, Zürich-Basel-New York: Karger 1951, pp.542–545
Stern, P.: Beitrag zur Wirkungsweise der Azulene. Arzneimittel-Forsch. 9, 551–553 (1959)
Stern, P., Milin, R.: Die antiallergische und antiphlogistische Wirkung der Azulene. Arzneimittel-Forsch. 6, 445–450 (1956)
Strandberg, K., Tuvemo, T.: Reduction of the tone of the isolated human umbilical artery by Indomethacin, Eicosa-5,8,11,14-tetraynoic acid and polyphloretin phosphate. Acta physiol. scand. 94, 319–326 (1975)
Tarayre, J.P., Lauressergues, H.: Preuve pharmacologiques de l’activité de l’hespéridine méthyl chalcone. Angéiologie 27, 197–203 (1975)
Tarayre, J.P., Lauressergues, H.: Etude de quelques propriétés pharmacologiques d’une association vasculotrope. Ann. Pharm. Fr. 34, 375–382 (1976)
Tarayre, J.P., Lauressergues, H.: Advantages of a combination of proteolytic enzymes, flavonoids and ascorbic acid in comparison with non-steroid anti-inflammatory agents. Arzneimittel-Forsch. (Drug Res.) 27, 1144–1149 (1977)
Texl, A.: The Effect of Catechol Complexes from Tea Leafs on Experimental Inflammation 19, 515–519(1963)
Thiele, K., Jakovlev, V., Isaac, O., Schuler, W.A.: Äther und von (-)-α-Bisabolol und analogen Mono- und Sesquiterpenoiden mit antiphlogistischer Wirkung. Arzneimittel-Forsch. 19, 1878–1882 (1969)
Thiemer, K., Stadler, R., Isaac, O.: Biochemische Untersuchungen von Kamillen-Inhaltstoffen. II. Einfluß von Kamillenextrakt auf die oxydative Phosphorylierung und den Hautstoffwechsel des Meerschweinchens. Arzneimittel-Forsch. 23, 756–759 (1973)
Uda, T.: The mode of inhibiting action of guaiazulene and some other antiinflammatory agents on anaphylactoid edemas. Nippon Yakurigaku Zasshi 56, 1151–1163 (1960). See Chem. Abst. 56, 4058h (1962)
Van Caneghem, P.: Influence of some hydrosoluble substances with vitamin P activity on the fragility of lysosomes in vitro. Biochem. Pharmacol. 21, 1543–1548 (1972)
Van Cauwenberge, H., Franchimont, P.: Action du Z 6000 (trihydroxyethylrutoside) sur divers tests d’inflammation expérimentale réalisés chez le rat. Arch. int. Pharmacodyn. 170, 74–80 (1967)
Van Cauwenberge, H., Franchimont, P.: Untersuchung der antiphlogistischen Eigenschaften von Trihydroxyäthylrutosid. Zbl. Phlebol. 7,110–121 (1968)
Van Cauwenberge, H., Lecomte, J., Cession-Fossion, A.: Sur quelques activités pharmacologiques de la (+)-catechine chez le rat. CR. Soc. Biol. (Paris) 165, 1195–1198 (1971)
Van Cauwenberge, H., Lecomte, J., Franchimont, P.: De la recherche expérimentale à la recherche clinique dans le domaine des affections capillaro-veineuses. Vie méd. 50, 108–116 (1969)
Vane, J.R.: Prostaglandins in the inflammatory response. In: Lepow, J.-H., Ward, P.A. (Eds.): Inflammation Mechanisms and Control, pp.261–279. London: Academic Press 1972
Vane, J.R.: Prostaglandins as mediators of inflammation. In: Samuelsson, B., Paoletti, R. (Eds.): Advances in Prostaglandin and Thromboxane Research, pp.791–801. New York: Raven Press 1976
Villanueva, R., Hinds, L., Katz, R.L., Eakins, K.E.: The effect of polyphloretin phosphate on smooth muscle actions of prostaglandins in the cat. J. Pharmacol. exp. Ther. 180, 78–85 (1972)
Vogel, G., Marek, M.L.: Rattenpfoten-Ödem durch Polyvinylpyrrolidon und seine pharmakologische Beeinflußbarkeit. Eine einfache Methode zur Beurteilung der Kapillarpermeabilität für Flüssigkeit und definierte Makromoleküle. Arzneimittel-Forsch. 11, 356–362 (1961)
Vogel, G., Marek, M.L., Oertner, R.: Untersuchungen zum Mechanismus der therapeutischen und toxischen Wirkung des Roßkastanien-Saponins Aescin. Arzneimittel-Forsch. 20, 699–703 (1970)
Vogel, G., Marek, M.L., Stoeckert, I.: Weitere Untersuchungen zum Wirkungsmechanismus des Roßkastanien-Saponins Aescin. Arzneimittel-Forsch. 13, 59–64 (1963)
Vogel, G., Uebel,H.: Das therapeutisch wirksame Prinzip der Roßkastanie (Aesculus hippocastanum). 3. Mitt: Zur Frage von Angriffspunkt und Wirkungsmechanismus. Arzneimittel-Forsch. 10, 275–280 (1960)
Vogin, E.E., Rossi, G.V.: Radiometrie quantitation of the inhibition of 5-hydroxytryptamine-induced edema in mice. Arch. int. Pharmacodyn. 144, 151–160 (1963)
Weissmann, G.: The role of lysosomes in inflammation and disease. Ann. Rev. Med. 18, 97–112 (1967)
Whitehouse, M.W.: Some biochemical and pharmacological properties of anti-inflammatory drugs. In: Jucker, E. (Ed.): Progress in Drug Research, Vol.VIII, pp.321–429. Basel-Stuttgart: Birkhäuser 1965
Wilhelm, D.L.: Chemical Mediators. In: Zweifach, B.W., Grant, L., McCluskey, R.T. (Eds.): The Inflammatory Process, pp. 389–425. New York-London: Academic Press 1965
Wilhelm, D.L.: Chemical Mediators,In: Zweifach, B.W., Grant, L., McCluskey, R.T. (Eds.): The Inflammatory Process, Vol.11, pp.251–301. New York-London: Academic Press 1973
Williams, T.J., Morley, J.: Prostaglandins as potentiators of increased vascular permeability in inflammation. Nature (Lond.) 246, 215–217 (1973)
Winder, C.V., Wax, J., Burr, V., Been, M., Rosière, C.E.: A study of pharmacological influences on ultraviolet erythema in guinea pigs. Arch. int. Pharmacodyn. 116, 261–292 (1958)
Winter, G.A.: Nonsteroid antiinflammatory agents. In: Jucker, E. (Ed.): Progress in Drug Research, Vol. 10, pp. 139–203. Basel-Stuttgart: Birkhäuser 1966a
Winter, C.A.: Nonsteroid anti-inflammatory agents. Ann. Rev. Pharmacol. 6, 157–174 (1966b)
Wolstenholme, G.E.W., O’Connor, C.M., (Eds.): Histamine. CIBA Foundation Symposium. London: J. & A. Churchill Ltd 1956
Yamasaki, H., Irino, S., Saito, N., Kondo, K., Jinzenji, K., Yamamoto, T.: Pharmacology of guaiazulene with special reference to anti-inflammatory effect due to inhibition of histamine release. Nippon Yakurigaku Zasshi 54, 362–377 (1958). See Chem. Abst. 53, 10525d (1959)
Yegnanarayan, R., Saraf, A.P., Balwani, J.H.: Comparison of anti-inflammatory activity of various extracts of Curcuma longa. Linn. Indian J. Med. Res. 64, 601–608 (1976)
Zierz, P., Lehmann, A., Craemer, R.: Die Beeinflußbarkeit akuter Entzündungsvorgänge durch Azulene. Hautarzt 8, 552–556 (1957)
Zweifach, B.W., Grant, L., McCluskey, R.T.: The Inflammatory Process, 2nd Ed., New York-London: Academic Press 1973, Vol.11
Zweig, M.H., Maling, H.M., Webster, M.E.: Inhibition of sodium urate-induced rat hindpaw edema by colchicine derivatives: correlation with antimitotic activity. J. Pharmacol. exp. Ther. 182, 344–350(1972)
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Gábor, M. (1979). Anti-Inflammatory Substances of Plant Origin. In: Vane, J.R., Ferreira, S.H. (eds) Anti-Inflammatory Drugs. Handbook of Experimental Pharmacology, vol 50 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66891-3_21
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