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Interaction Between Iron-Regulatory Proteins and Their RNA Target Sequences, Iron-Responsive Elements

  • Chapter
Cytoplasmic fate of messenger RNA

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 18))

Abstract

Iron is perhaps the most essential inorganic element necessary for cell growth, and, acting as both donor and acceptor of electrons, has evolved as an integral cofactor and component of many proteins (Crichton and Ward 1992; Aisen 1994). Indeed, variability in the protein ligands coordinating iron can evoke a wide-ranging flexibility in redox potentials. Regulation of the amount of free intracellular iron is critical, and in mammals is mediated at several steps, including the uptake of iron by endocytosis of receptor-bound transferrin, and the storage of iron by ferritin within the cell (Baker and Morgan 1994). Insufficient iron will prevent cell division, whereas iron overload is toxic, due in large part to the potential for oxidative damage (Crichton 1991).

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Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK

    B. R. Henderson

  2. Genetics Unit, Swiss Institute for experimental Cancer Research (ISREC), Chemin des Boveresses 155, 1066, Epalinges s/Lausanne, Switzerland

    L. C. Kühn

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  1. B. R. Henderson
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  2. L. C. Kühn
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  1. Institut de Génétique Moléculaire, C.N.R.S., 1919 route de Mende, B.P. 5051, 34033, Montpellier Cedex 01, France

    Philippe Jeanteur

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© 1997 Springer-Verlag Berlin Heidelberg

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Henderson, B.R., Kühn, L.C. (1997). Interaction Between Iron-Regulatory Proteins and Their RNA Target Sequences, Iron-Responsive Elements. In: Jeanteur, P. (eds) Cytoplasmic fate of messenger RNA. Progress in Molecular and Subcellular Biology, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60471-3_6

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  • DOI: https://doi.org/10.1007/978-3-642-60471-3_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64420-7

  • Online ISBN: 978-3-642-60471-3

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