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Mechanisms of Organophosphate Resistance in Insects

  • Chapter
Biochemical Sites of Insecticide Action and Resistance

Abstract

The organophosphate (OP) insecticides were first introduced as pest control agents over 50 years ago. These compounds still account for approximately 30% of the registered synthetic insecticides and acaricides in the US, and are used in a variety of agriculture, public hygiene and medical settings (Ware 1994). Organophosphate insecticides cause toxicity through inhibition of acetylcholinesterase (AChE), which is responsible for the degradation of the excitatory neurotransmitter, acetylcholine, thereby terminating transmission of nerve impulses at cholinergic synapses. Inhibition of this enzyme prolongs the residence time of acetylcholine at synapses resulting in hyper-excitation and eventual death.

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  1. Department of Entomology, 202 Plant Industry Bldg. University of Nebraska, Lincoln, NE, 68583-0816, USA

    Blair D. Siegfried & Michael E. Scharf

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  1. Blair D. Siegfried
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  1. Department of Entomology Agricultural Research Organization, The Volcani Center, Bet Dagan, 50250, Isarael

    Isaac Ishaaya

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Siegfried, B.D., Scharf, M.E. (2001). Mechanisms of Organophosphate Resistance in Insects. In: Ishaaya, I. (eds) Biochemical Sites of Insecticide Action and Resistance. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59549-3_13

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  • DOI: https://doi.org/10.1007/978-3-642-59549-3_13

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