Abstract
Implementation of thermal dosimetry requires three steps. First, it is necessary to use accurate thermometers. This subject is covered in Chap. 15 of this volume. Second, it is necessary to use a measure of treatment effect that has biological significance (i.e., there is a quantitative relationship between the measure of treatment delivered and the cytotoxic effect of the treatment). A large database from in vitro and in vivo models has provided useful concepts for this aspect of dosimetry, although recent data from human cells suggest that some key revisions to the concepts may be necessary. In this chapter the relations between temperature, time at temperature, and cytotoxicity will be reviewed. In addition, factors that are known to influence the accuracy of these measures of effect will be presented, along with an emphasis on their clinical relevance.
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© 1995 Springer-Verlag Berlin Heidelberg
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Dewhirst, M.W. (1995). Thermal Dosimetry. In: Seegenschmiedt, M.H., Fessenden, P., Vernon, C.C. (eds) Thermoradiotherapy and Thermochemotherapy. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57858-8_6
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DOI: https://doi.org/10.1007/978-3-642-57858-8_6
Publisher Name: Springer, Berlin, Heidelberg
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