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Roles of the Extracellular Matrix in Retinal Development and Maintenance

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Vertebrate Eye Development

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 31))

Abstract

The extracellular matrix (ECM) is a highly organized meshwork of secreted macromolecules that consists of proteins, proteoglycans, and polysaccharides. Components of the ECM provide cells with different signals that are involved in many aspects of the development of multicellular organisms, such as: (1) when to start, continue, or stop dividing; (2) when to differentiate; (3) where to migrate; (4) how to polarize; (5) where to form a synapse; and (6) whether to die or survive. Thus, ECM molecules may be playing many different roles in the development of a complex tissue such as the retina.

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References

  • Aberdam D, Galliano MF, Vailly J, Pulkkinen L, Bonifas J, Christiano AM, Tryggvason K, Uitto J, Epstein EH Jr, Ortonne JP et al. (1994) Herlitz’s junctional epidermolysis bullosa is linked to mutations in the gene (LAMC2) for the gamma 2 subunit of nicein/kalinin (LAMININ-5). Nat Genet 6: 299–304

    Article  PubMed  CAS  Google Scholar 

  • Acharya S, Rayborn ME, Hollyfield JG (1998) Characterization of SPACR, a sialoprotein associated with cones and rods present in the interphotoreceptor matrix of the human retina: immunological and lectin binding analysis. Glycobiol 8: 997–1006

    Article  CAS  Google Scholar 

  • Acharya S, Rodriguez IR, Moreira EF, Midura RJ, Misono K, Todres E, Hollyfield JG (1998) SPACR, a novel interphotoreceptor matrix glycoprotein in human retina that interacts with hyaluronan. J Biol Chem 273: 31599–31606

    Article  PubMed  CAS  Google Scholar 

  • Adler AJ, Klucznik KM (1982) Proteins and glycoproteins of the bovine interphotoreceptor matrix: composition and fractionation. Exp Eye Res 34: 423–434

    Article  PubMed  CAS  Google Scholar 

  • Altshuler D, Lo Turco JJ, Rush J, Cepko C (1993) Taurine promotes the differentiation of a vertebrate retinal cell type in vitro. Development 119: 1317–1328

    PubMed  CAS  Google Scholar 

  • Anchan RM, Reh TA (1995) Transforming growth factor-β-3 is mitogenic for rat retinal progenitor cells in vitro. J Neurobiol 28: 133–145

    Article  PubMed  CAS  Google Scholar 

  • Anderson DH, Johnson LV, Hageman GS (1995) Vitronectin receptor expression and distribution at the photoreceptor-retinal pigment epithelial interface. J Comp Neurol 360: 1–16

    Article  PubMed  CAS  Google Scholar 

  • Aumailley M, Gimond C, Patricia R (1996) Integrin-mediated cellular interactions with laminins. In: Ekblom P, Timpl R (eds) The laminins. Harwood Academic Publishers, Amsterdam, pp 127–158

    Google Scholar 

  • Austin CP, Feldman DE, Ida JA, Jr, Cepko CL (1995) Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch. Development 121: 3637–3650

    PubMed  CAS  Google Scholar 

  • Bach G, Berman ER (1971) Amino sugar-containing compounds of the retina. I. Isolation and identification. Biochim Biophys Acta 252: 453–461

    Article  PubMed  CAS  Google Scholar 

  • Baudoin C, Miguel C, Gagnoux Palacios L, Pulkkinen L, Christiano AM, Uitto J, Tadini G, Ortonne JP, Meneguzzi G (1994) A novel homozygous nonsense mutation in the LAMC2 gene in patients with the Herlitz junctional epidermolysis bullosa. Hum Mol Genet 3:1909–1910

    Article  PubMed  CAS  Google Scholar 

  • Belliveau MJ, Cepko CL (1999) Extrinsic and intrinsic factors control the genesis of amacrine and cone cells in the rat retina. Development 126: 555–566

    PubMed  CAS  Google Scholar 

  • Berman ER, Bach G (1968) The acid mucopolysaccharides of cattle retina. Biochem J 108: 75–88

    PubMed  CAS  Google Scholar 

  • Bermingham-McDonogh O, McCabe KL, Reh TA (1996) Effects of GGF/neuregulins on neuronal survival and neurite outgrowth correlate with erbB2/neu expression in developing rat retina. Development 122: 1427–1438

    PubMed  CAS  Google Scholar 

  • Blank M, Koulen P, Blake DJ, Kröger S (1999) Dystrophin and beta-dystroglycan in photoreceptor terminals from normal and mdx3Cv mouse retinae. Eur J Neurosci 11: 2121–2133

    Article  PubMed  CAS  Google Scholar 

  • Blanks JC, Adinolfi AM, Lolley RN (1974) Synaptogenesis in the photoreceptor terminal of the mouse retina. J Comp Neurol 156: 81–93

    Article  PubMed  CAS  Google Scholar 

  • Burgeson RE, Chiquet M, Deutzmann R, Ekblom P, Engel J, Kleinman H, Martin GR, Meneguzzi G, Paulsson M, Sanes J, Timpl R, Tryggvason K, Yamada Y, Yurcheno PD (1994) A new nomenclature for the laminins. Matrix Biol 14:209–211

    Article  PubMed  CAS  Google Scholar 

  • Campbell M, Chader GJ (1988) Retinoblastoma cells in tissue culture. Ophthalmic Paediatr Genet 9: 171–199

    Article  PubMed  CAS  Google Scholar 

  • Campochiaro PA, Chang M, Ohsato M, Vinores SA, Nie Z, Hjelmeland L, Mansukhani A, Basilico C, Zack DJ (1996) Retinal degeneration in transgenic mice with photoreceptorspecific expression of a dominant-negative fibroblast growth factor receptor. J Neurosci 16: 1679–1688

    PubMed  CAS  Google Scholar 

  • Carwile ME, Culbert RB, Sturdivant RL, Kraft TW (1998) Rod outer segment maintenance is enhanced in the presence of bFGF, CNTF and GDNF. Exp Eye Res 66: 791–805

    Article  PubMed  CAS  Google Scholar 

  • Cepko CL (1999) The roles of intrinsic and extrinsic cues and bHLH genes in the determination of retinal cell fates. Curr Opin Neurobiol 9: 37–46

    Article  PubMed  CAS  Google Scholar 

  • Chaitin MH, Wortham HS, Brun-Zinkernagel AM (1994) Immunocytochemical localization of CD44 in the mouse retina. Exp Eye Res 58: 359–365

    Article  PubMed  CAS  Google Scholar 

  • Champliaud MF, Lunstrum GP, Rousselle P, Nishiyama T, Keene DR, Burgeson RE (1996) Human amnion contains a novel laminin variant, laminin 7, which like laminin 6, covalently associates with laminin 5 to promote stable epithelial-stromal attachment. J Cell Biol 132:1189–1198

    Article  PubMed  CAS  Google Scholar 

  • Chen W, Joos TO, Defoe DM (1997) Evidence for beta 1-integrins on both apical and basal surfaces of Xenopus retinal pigment epithelium. Exp Eye Res 64: 73–84

    Article  PubMed  CAS  Google Scholar 

  • Claudepierre T, Rodius F, Frasson M, Fontaine V, Picaud S, Dreyfus H, Mornet D, Rendon A (1999) Differential distribution of dystrophins in rat retina. Invest Ophthalmol Visual Sci 40:1520–1529

    CAS  Google Scholar 

  • De Roberts E (1956) Electron microscope observations on the submicroscopic organization of retinal rods. J Biophys Biochem Cytol 2: 319–334

    Article  Google Scholar 

  • De Roberts E (1960) Some observations on the ultrastructure and morphogenesis of photoreceptors. J Gen Physiol 43: 1–13

    Article  Google Scholar 

  • Désiré L, Courtois Y, Jeanny JC (1998) Suppression of fibroblast growth factors 1 and 2 by antisense oligonucleotides in embryonic chick retinal cells in vitro inhibits neuronal differentiation and survival. Exp Cell Res 241: 210–221

    Article  PubMed  Google Scholar 

  • D’Souza VN, Nguyen TM, Morris GE, Karges W, Pillers DA, Ray PN (1995) A novel dystrophin isoform is required for normal retinal electrophysiology. Hum Mol Genet 4: 837–842

    Article  PubMed  Google Scholar 

  • Dong LJ, Chung AE (1991) The expression of the genes for entactin, laminin A, laminin B1 and laminin B2 in murine lens morphogenesis and eye development. Differentiation 48: 157–172

    Article  PubMed  CAS  Google Scholar 

  • Drenckhahn D, Holbach M, Ness W, Schmitz F, Anderson LV (1996) Dystrophin and the dystrophin-associated glycoprotein, beta-dystroglycan, co-localize in photoreceptor synaptic complexes of the human retina. Neuroscience 73: 605–612

    Article  PubMed  CAS  Google Scholar 

  • Engvall E, Earwicker D, Haaparanta T, Ruoslahti E, Sanes JR (1990) Distribution and isolation of four laminin variants; tissue-restricted distribution of heterotrimers assembled from five different subunits. Cell Regul 1: 731–740

    PubMed  CAS  Google Scholar 

  • Eudy JD, Weston MD, Yao S, et al (1998) Mutation of a gene encoding a protein with extracellular matrix motifs in Usher syndrome type IIa. Science 280: 1753–1757

    Article  PubMed  CAS  Google Scholar 

  • Ezzeddine ZD, Yang X, DeChiara T, Yancopoulos G, Cepko CL (1997) Postmitotic cells fated to become rod photoreceptors can be respecified by CNTF treatment of the retina. Development 124: 1055–1067

    PubMed  CAS  Google Scholar 

  • Faham S, Linhardt RJ, Rees DC (1998) Diversity does make a difference: fibroblast growth factor-heparin interactions. Curr Opin Struct Biol 8: 578–586

    Article  PubMed  CAS  Google Scholar 

  • Faktorovich EG, Steinberg RH, Yasumura D, Matthes MT, LaVail MM (1990) Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor. Nature 347:83–86

    Article  PubMed  CAS  Google Scholar 

  • Faktorovich EG, Steinberg RH, Yasumura D, Matthes MT, LaVail MM (1992) Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat. J Neurosci 12: 3554–3567

    PubMed  CAS  Google Scholar 

  • Farber DB, Danciger M (1997) Identification of genes causing photoreceptor degenerations leading to blindness. Curr Opin Neurobiol 7: 666–673

    Article  PubMed  CAS  Google Scholar 

  • Fariss RN, Apte SS, Luthert PJ, Bird AC, Milam AH (1998) Accumulation of tissue inhibitor of metalloproteinases-3 in human eyes with Sorsby’s fundus dystrophy or retinitis pigmentosa. Br j Ophthalmol 82: 1329–1334

    Article  PubMed  CAS  Google Scholar 

  • Fitzgerald KM, Cibis GW, Giambrone SA, Harris DJ (1994) Retinal signal transmission in Duchenne muscular dystrophy: evidence for dysfunction in the photoreceptor/deplorizing bipolar cell pathway. J Clin Invest 93: 2425–2430

    Article  PubMed  CAS  Google Scholar 

  • Fontaine V, Kinkl N, Sahel J, Dreyfus H, Hicks D (1998) Survival of purified rat photoreceptors in vitro is stimulated directly by fibroblast growth factor-2. J Neurosci 18: 9662–9672

    PubMed  CAS  Google Scholar 

  • Frade JM, Martinez Morales JR, Rodriguez Tebar A (1996) Laminin-1 selectively stimulates neuron generation from cultured retinal neuroepithelial cells. Exp Cell Res 222: 140–149

    Article  PubMed  CAS  Google Scholar 

  • Fuhrmann S, Kirsch M, Hofmann HD (1995) Ciliary neurotrophic factor promotes chick photoreceptor development in vitro. Development 121: 2695–2706

    PubMed  CAS  Google Scholar 

  • Galbavy ES, Olson MD (1979) Morphogenesis of rod cells in the retina of the albino rat: a scanning electron microscopic study. Anat Rec 195: 707–717

    Article  PubMed  CAS  Google Scholar 

  • Gao H, Hollyfield JG (1992) Basic fibroblast growth factor (bFGF) immunolocalization in the rodent outer retina demonstrated with an anti-rodent bFGF antibody. Brain Res 585: 355–360

    Article  PubMed  CAS  Google Scholar 

  • Gautam M, Noakes PG, Moscoso L, Rupp F, Scheller RH, Merlie JP, Sanes JR (1996) Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell 85: 525–535

    Article  PubMed  CAS  Google Scholar 

  • Gensburger C, Labourdette G, Sensenbrenner M (1987) Brain basic fibroblast growth factor stimulates the proliferation of rat neuronal precursor cells in vitro. FEBS Lett 217: 1–5

    Article  PubMed  CAS  Google Scholar 

  • Georges-Labouesse E, Mark M, Messaddeq N, Gansmüller A (1998) Essential role of alpha 6 integrins in cortical and retinal lamination. Curr Biol 8: 983–986

    Article  PubMed  CAS  Google Scholar 

  • Girlanda P, Quartarone A, Buceti R, Sinicropi S, Macaione V, Saad FA, Messina L, Danieli GA, Ferreri G, Vita G (1997) Extra-muscle involvement in dystrophinopathies: an electroretinography and evoked potential study. J Neurol Sci 146: 127–132

    Article  PubMed  CAS  Google Scholar 

  • Guillemot F, Cepko CL (1992) Retinal fate and ganglion cell differentiation are potentiated by acidic FGF in an in vitro assay of early retinal development. Development 114: 743–754

    PubMed  CAS  Google Scholar 

  • Gundersen D, Powell SK, Rodriguez Boulan E (1993) Apical polarization of N-CAM in retinal pigment epithelium is dependent on contact with the neural retina. J Cell Biol 121: 335–343

    Article  PubMed  CAS  Google Scholar 

  • Haas TA, Plow EF (1994) Integrin-ligand interactions: a year in review. Curr Opin Cell Biol 6:656–662

    Article  PubMed  CAS  Google Scholar 

  • Hageman GS, Johnson LV (1987) Chondroitin 6-sulfate glycosaminoglycan is a major constituent of primate cone photoreceptor matrix sheaths. Curr Eye Res 6: 639–646

    Article  PubMed  CAS  Google Scholar 

  • Hageman GS, Kirchoff Rempe MA, Lewis GP, Fisher SK, Anderson DH (1991) Sequestration of basic fibroblast growth factor in the primate retinal interphotoreceptor matrix. Proc Natl Acad Sci USA 88: 6706–6710

    Article  PubMed  CAS  Google Scholar 

  • Hankin MH, Lagenaur CF (1994) Cell adhesion molecules in the early developing mouse retina: retinal neurons show preferential outgrowth in vitro on L1 but not N-CAM. J Neurobiol 25:472–487

    Article  PubMed  CAS  Google Scholar 

  • Helbling-Leclerc A, Zhang X, Topaloglu H, Cruaud C, Tesson F, Weissenbach J, Tome FM, Schwartz K, Fardeau M, Tryggvason K, et al. (1995) Mutations in the laminin alpha 2-chain gene (LAMA2) cause merosin-deficient congenital muscular dystrophy. Nat Genet 11:216–218

    Article  PubMed  CAS  Google Scholar 

  • Henrique D, Hirsinger E, Adam J, Le Roux I, Pourquie O, Ish-Horowicz D, Lewis J (1997) Maintenance of neuroepithelial progenitor cells by delta-notch singalling in the embryonic chick retina. Curr Biol 7: 661–670

    Article  PubMed  CAS  Google Scholar 

  • Hewitt AT, Lindsey JD, Carbott D, Adler R (1990) Photoreceptor survival-promoting activity in interphotoreceptor matrix preparations: characterization and partial purification. Exp Eye Res 50:79–88

    Article  PubMed  CAS  Google Scholar 

  • Hicks D, Courtois Y (1992) Fibroblast growth factor stimulates photoreceptor differentiation in vitro. J Neurosci 12: 2022–2033

    PubMed  CAS  Google Scholar 

  • Hinds JW, Hinds PL (1979) Differentiation of photoreceptors and horizontal cells in the embryonic mouse retina: an electron microscopic, serial section analysis. J Comp Neurol 187:495–511

    Article  PubMed  CAS  Google Scholar 

  • Hoffman EP, Brown RH, Jr, Kunkel LM (1987) Dystrophin: the protein product of the Duchenne muscular dystrophy locus. Cell 51: 919–928

    Article  PubMed  CAS  Google Scholar 

  • Hollyfield JG, Rayborn ME, Tammi M, Tammi R (1998) Hyaluronan in the interphotoreceptor matrix of the eye: species differences in content, distribution, ligand binding and degradation. Exp Eye Res 66: 241–248

    Article  PubMed  CAS  Google Scholar 

  • Holt CE, Bertsch TW, Ellis HM, Harris WA (1988) Cellular determination in the Xenopus retina is independent of lineage and birth date. Neuron 1: 15–26

    Article  PubMed  CAS  Google Scholar 

  • Howard PL, Dally GY, Wong MH, Ho A, Weleber RG, Pillers DA, Ray PN (1998) Localization of dystrophin isoform Dp71 to the inner limiting membrane of the retina suggests a unique functional contribution of Dp71 in the retina. Hum Mol Genet 7: 1385–1391

    Article  PubMed  CAS  Google Scholar 

  • Humayun MS, deJaun E, Weiland JD, Dagnelie G, Katona S, Greenberg R, Suzuke S (1999) Pattern electrical stimulation of the human retina. Vision Res 39: 2569–2576

    Article  PubMed  CAS  Google Scholar 

  • Hunter DD, Brunken WJ (1997) Beta 2 laminins modulate neuronal phenotype in the rat retina. Mol Cell Neurosci 10: 7–15

    Article  PubMed  CAS  Google Scholar 

  • Hunter DD, Murphy MD, Olsson CV, Brunken WJ (1992) S-laminin expression in adult and developing retinae: a potential cue for photoreceptor morphogenesis. Neuron 8: 399–413

    Article  PubMed  CAS  Google Scholar 

  • Hyatt GA, Schmitt EA, Fadool JM, Dowling JE (1996) Retinoic acid alters photoreceptor development in vivo. Proc Natl Acad Sci USA 93: 13298–13303

    Article  PubMed  CAS  Google Scholar 

  • Hyatt GA, Schmit, EA, Marsh Armstrong NR, Dowling JE (1992) Retinoic acid-induced duplication of the zebrafish retina. Proc Natl Acad Sci USA 89: 8293–8297

    Article  PubMed  CAS  Google Scholar 

  • Hyatt GA, Schmitt EA, Marsh Armstrong N, McCaffery P, Drager UC, Dowling JE (1996) Retinoic acid establishes ventral retinal characteristics. Development 122: 195–204

    PubMed  CAS  Google Scholar 

  • Hyer J, Mima T, Mikawa T (1998) FGF1 patterns the optic vesicle by directing the placement of the neural retina domain. Development 125: 869–877

    PubMed  CAS  Google Scholar 

  • Kameya S, Araki E, Katsuki M, Mizota A, Adachi E, Nakahara K, Nonaka I, Sakuragi S, Takeda S, Nabeshima Y (1997) Dp260 disrupted mice revealed prolonged implicit time of the b-wave in ERG and loss of accumulation of beta-dystroglycan in the outer plexiform layer of the retina. Hum Mol Genet 6: 2195–2203

    Article  PubMed  CAS  Google Scholar 

  • Kelley MW, Turner JK, Reh TA (1994) Retinoic acid promotes differentiation of photoreceptors in vitro. Development 120: 2091–2102

    PubMed  CAS  Google Scholar 

  • Kivirikko S, McGrath JA, Baudoin C, Aberdam D, Ciatti S, Dunnill MG, McMillan JR, Eady RA, Ortonne JP, Meneguzzi G, et al. (1995) A homozygous nonsense mutation in the alpha 3 chain gene of laminin 5 (LAMA3) in lethal (Herlitz) junctional epidermolysis bullosa. Hum Mol Genet 4: 959–962

    Article  PubMed  CAS  Google Scholar 

  • Koch M, Olson PF, Albus A, Jin W, Hunter DD, Brunken WJ, Burgeson RE, Champliaud MF (1999) Characterization and expression of the laminin gamma3 chain: a novel, non-basement membrane-associated, laminin chain. J Cell Biol 145: 605–618

    Article  PubMed  CAS  Google Scholar 

  • Koulen P, Blank M, Kröger S (1998) Differential distribution of beta-dystroglycan in rabbit and rat retina. J Neurosci Res 51: 735–747

    Article  PubMed  CAS  Google Scholar 

  • Kröger S (1997) Differential distribution of agrin isoforms in the developing and adult avian retina. Mol Cell Neurosci 10: 149–161

    Article  PubMed  Google Scholar 

  • Kröger S, Horton SE, Honig LS (1996) The developing avian retina expresses agrin isoforms during synaptogenesis. J Neurobiol 29: 165–182

    Article  PubMed  Google Scholar 

  • LaVail MM, Unoki K, Yasumura D, Matthes MT, Yancopoulos GD, Steinberg RH (1992) Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc Nat Acad Sci USA 89: 11249–11253

    Article  PubMed  CAS  Google Scholar 

  • Lazarus HS, Hageman GS (1992) Xyloside-induced disruption of interphotoreceptor matrix proteoglycans results in retinal detachment. Invest Ophthalmol Visual Sci 33: 364–376

    CAS  Google Scholar 

  • Lenk U, Oexle K, Voit T, Ancker U, Hellner KA, Speer A, Hubner C (1996) A cysteine 3340 substitution in the dystroglycan-binding domain of dystrophin associated with Duchenne muscular dystrophy, mental retardation and absence of the ERG b-wave. Hum Mol Genet 5: 973–975

    Article  PubMed  CAS  Google Scholar 

  • Lentz SI, Miner JH, Sanes JR, Snider WD (1997) Distribution of the ten known laminin chains in the pathways and targets of developing sensory axons. J Comp Neurol 378: 547–561

    Article  PubMed  CAS  Google Scholar 

  • Lesley J, Hyman R (1998) CD44 structure and function. Front Biosci 3: D616–630

    PubMed  CAS  Google Scholar 

  • Li A, Lane WS, Johnson LV, Chader GJ, Tombran-Tink J (1995) Neuron-specific enolase: a neuronal survival factor in the retinal extracellular matrix? J Neurosci 15: 385–393

    PubMed  CAS  Google Scholar 

  • Libby RT, Hunter DD, Brunken WJ (1996) Developmental expression of laminin β32 in rat retina. Further support for a role in rod morphogenesis. Invest Ophthalmol Visual Sci 37: 1651–1661

    CAS  Google Scholar 

  • Libby RT, Yin X, Selfors LM, Brunken WJ, Hunter DD (1997) Identification of the cellular source of laminin 32 in adult and developing vertebrate retinae. J Comp Neurol 389: 355–367

    Article  Google Scholar 

  • Libby RT, Lavallee CR, Balkema GW, Brunken WJ, Hunter DD (1999) Disruption laminin beta 2 chain production causes alterations in morphology and function in the cns. J Neurosci 19:9399–9411

    PubMed  CAS  Google Scholar 

  • Lillien L (1995) Changes in retinal cell fate induced by overexpression of EGF receptor. Nature 377:158–162

    Article  PubMed  CAS  Google Scholar 

  • Lillien L, Cepko C (1992) Control of proliferation in the retina: temporal changes in responsiveness to FGF and TGF alpha. Development 115: 253–266

    PubMed  CAS  Google Scholar 

  • Lin H, Clegg DO (1998) Integrin alphavbeta5 participates in the binding of photoreceptor rod outer segments during phagocytosis by cultured human retinal pigment epithelium. Invest Ophthalmol Visual Sci 39: 1703–1712

    CAS  Google Scholar 

  • Marinkovich MP, Lunstrum GP, Keene DR, Burgeson RE (1992) The dermal-epidermal junction of human skin contains a novel laminin variant. J Cell Biol 119: 695–703

    Article  PubMed  CAS  Google Scholar 

  • Masuda K, Watanabe I, Unoki K, Ohba N, Muramatsu T (1995) Functional Rescue of photoreceptors from the damaging effects of constant light by survival-promoting factors in the rat. Invest Ophthalmol Visual Sci 36: 2142–2146

    CAS  Google Scholar 

  • Matsunaga M, Hatta K, Takeichi M (1988) Role of N-cadherin cell adhesion molecules in the histogenesis of neural retina. Neuron 1: 289–295

    Article  PubMed  CAS  Google Scholar 

  • McFarlane S, Zuber ME, Holt CE (1998) A role for the fibroblast growth factor receptor in cell fate decisions in the developing vertebrate retina. Development 125: 3967–3975

    PubMed  CAS  Google Scholar 

  • McKeehan WL, Wang F, Kan M (1998) The heparan sulfate-fibroblast growth factor family: diversity of structure and function. Prog Nucleic Acid Res Mol Biol 59: 135–176

    Article  PubMed  CAS  Google Scholar 

  • McLoon SC, McLoon LK, Palm SL, Furcht LT (1988) Transient expression of laminin in the optic nerve of the developing rat. J Neurosci 8: 1981–1990

    PubMed  CAS  Google Scholar 

  • Mieziewska K, Szel A, Van Veen T, Aguirre GD, Philp N (1994) Redistribution of insoluble interphotoreceptor matrix components during photoreceptor differentiation in the mouse retina. J Comp Neurol 345: 115–124

    Article  PubMed  CAS  Google Scholar 

  • Millaruelo AI, Nieto Sampedro M, Cotman CW (1988) Cooperation between nerve growth factor and laminin or fibronectin in promoting sensory neuron survival and neurite outgrowth. Brain Res 466: 219–228

    PubMed  CAS  Google Scholar 

  • Miner JH, Cunningham J, Sanes JR (1998) Roles for laminin in embryogenesis: exencephaly, syndactyly, and placentopathy in mice lacking the laminin alpha5 chain. J Cell Biol 143:1713–1723

    Article  PubMed  CAS  Google Scholar 

  • Miner JH, Patton BL, Lentz SI, Gilbert DJ, Snider WD, Jenkins NA, Copeland NG, Sanes JR (1997) The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha 1–5, identification of heterotrimeric laminins 8–11, and cloning of a novel alpha3 isoform. J Cell Biol 137: 685–701

    Article  PubMed  CAS  Google Scholar 

  • Miyagoe Y, Hanaoka K, Nonaka I, Hayasaka M, Nabeshima Y, Arahata K, Takeda S (1997) Laminin alpha2 chain-null mutant mice by targeted disruption of the Lama2 gene: a new model of merosin (laminin 2)-deficient congenital muscular dystrophy. FEBS Lett 415: 33–39

    Article  PubMed  CAS  Google Scholar 

  • Montanaro F, Carbonetto S, Campbell KP, Lindenbaum M (1995) Dystroglycan expression in the wild type and mdx mouse neural retina: synaptic colocalization with dystrophin, dystrophin-related protein but not laminin. J Neurosci Res 42: 528–538

    Article  PubMed  CAS  Google Scholar 

  • Morimoto A, Matsuda S, Uryu K, Fujita H, Okumura N, Sakanaka M (1993) Light- and electronmicroscopic localization of basic fibroblast growth factor in adult rat retina. Okajimas Folia Anat Jpn 70:7–12

    PubMed  CAS  Google Scholar 

  • Morissette N, Carbonetto S (1995) Laminin α2 chain (M chain) is found within the pathway of avian and murine retinal projections. J Neurosci 15: 8067–8082

    PubMed  CAS  Google Scholar 

  • Morrow EM, Belliveau MJ, Cepko CL (1998) Two phases of rod photoreceptor differentiation during rat retinal development. J Neurosci 18: 3738–3748

    PubMed  CAS  Google Scholar 

  • Neophytou C, Vernallis AB, Smith A, Raff MC (1997) Muller-cell-derived leukaemia inhibitory factor arrests rod photoreceptor differentiation at a postmitotic pre-rod stage of development. Development 124: 2345–2354

    PubMed  CAS  Google Scholar 

  • Nir I, Cohen D, Papermaster DS (1984) Immunocytochemical localization of opsin in the cell membrane of developing rat retinal photoreceptors. J Cell Biol 98: 1788–1795

    Article  PubMed  CAS  Google Scholar 

  • Noakes PG, Gautam M, Mudd J, Sanes JR, Merlie JP (1995) Aberrant differentiation of neuromuscular junctions in mice lacking s-laminin/laminin 32. Nature 374: 258–262

    Article  PubMed  CAS  Google Scholar 

  • Noakes PG, Miner JH, Gautam M, Cunningham JM, Sanes JR, Merlie JP (1995) The renal glomerulus of mice lacking s-laminin/laminin β 2: nephrosis despite molecular compensation by laminin β1. Nat Genet 10: 400–406

    Article  PubMed  CAS  Google Scholar 

  • Obata S, Usukura J (1992) Morphogenesis of the photoreceptor outer segment during postnatal development in the mouse (BALB/c) retina. Cell Tissue Res 269: 39–48

    Article  PubMed  CAS  Google Scholar 

  • Olney JW (1968) An electron microscopic study of synapse formation, receptor outer segment development, and other aspects of developing mouse retina. Invest Ophthalmol 7: 250–268

    PubMed  CAS  Google Scholar 

  • Olney JW (1968) Centripetal sequence of appearance of receptor-bipolar synaptic structures in developing mouse retina. Nature 218:281–282

    Article  PubMed  CAS  Google Scholar 

  • Pilkers DA, Weleber RG, Green DG, Rash SM, Dally GY, Howard PL, Powers MR, Hood DC, Chapman VM, Ray PN, Woodward WR (1999) Effects of dystrophin isoforms on signal transduction through neural retina: genotype-phenotype analysis of duchenne muscular dystrophy mouse mutants. Mol Genet Metab 66: 100–110

    Article  Google Scholar 

  • Pillers DM, Bulman DE, Weleber RG, Sigesmund DA, Musarella MA, Powell BR, Murphey WH, Westall C, Panton C, Becker LE et al. (1993) Dystrophin expression in the human retina is required for normal function as defined by electroretinography. Nat Genet 4: 82–86

    Article  PubMed  CAS  Google Scholar 

  • Pillers DM, Weleber RG, Woodward WR, Green DG, Chapman VM, Ray PN (1995) mdxCv3 mouse is a model for electroretinography of Duchenne/Becker muscular dystrophy. Invest Ophthalmol Visual Sci 36: 462–466

    CAS  Google Scholar 

  • Pittack C, Grunwald GB, Reh TA (1997) Fibroblast growth factors are necessary for neural retina but not pigmented epithelium differentiation in chick embryos. Development 124:805–816

    PubMed  CAS  Google Scholar 

  • Pulkkinen L, Christiano AM, Airenne T, Haakana H, Tryggvason K, Uitto J (1994) Mutations in the gamma 2 chain gene (LAMC2) of kalinin/laminin 5 in the junctional forms of epidermolysis bullosa. Nat Genet 6: 293–297

    Article  PubMed  CAS  Google Scholar 

  • Pulkkinen L, Christiano AM, Airenne T, Haakana H, Tryggvason K, Uitto J (1994) Mutations in the γ2 chain gene (LAMC2) of kalinin/laminin 5 in the junctional forms of epidermolysis bullosa. Nat Genet 6: 293–297

    Article  PubMed  CAS  Google Scholar 

  • Pulkkinen L, Christiano AM, Gerecke D, Wagman DW, Burgeson RE, Pittelkow MR, Uitto, J. (1994) A homozygous nonsense mutation in the β3 chain gene of laminin 5 (LAMB3) in Herlitz junctional epidermolysis bullosa. Genomics 24: 357–360

    Article  PubMed  CAS  Google Scholar 

  • Pulkkinen L, Christiano AM, Gerecke D, Wagman DW, Burgeson RE, Pittelkow MR, Uitto J (1994) A homozygous nonsense mutation in the beta 3 chain gene of laminin 5 (LAMB3) in Herlitz junctional epidermolysis bullosa. Genomics 24: 357–360

    Article  PubMed  CAS  Google Scholar 

  • Reh TA (1992) Cellular interactions determine neuronal phenotypes in rodent retinal cultures. J Neurobiol 23: 1067–1083

    Article  PubMed  CAS  Google Scholar 

  • Rousselle P, Lunstrum GP, Keene DR, Burgeson RE (1991) Kalinin: an epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments. J Cell Biol 114: 567–576

    Article  PubMed  CAS  Google Scholar 

  • Ryan MC, Lee K, Miyashita Y, Carter WG (1999) Targeted disruption of the LAMA3 gene in mice reveals abnormalities in survival and late stage differentiation of epithelial cells. J Cell Biol 145: 1309–1324

    Article  PubMed  CAS  Google Scholar 

  • Sarthy PV, Fu M (1990) Localization of laminin B1 mRNA in retinal ganglion cells by in situ hybridization. J Cell Biol 110:2099–2108

    Article  PubMed  CAS  Google Scholar 

  • Schmitz F, Drenckhahn D (1997) Localization of dystrophin and beta-dystroglycan in bovine retinal photoreceptor processes extending into the postsynaptic dendritic complex. Histochem Cell Biol 108: 249–255

    Article  PubMed  CAS  Google Scholar 

  • Schmitz F, Holbach M, Drenckhahn D (1993) Colocalization of retinal dystrophin and actin in postsynaptic dendrites of rod and cone photoreceptor synapses. Histochemistry 100:473–479

    Article  PubMed  CAS  Google Scholar 

  • Schmidt MF, Kater SB (1995) Depolarization and laminin independently enable bFGF to promote neuronal survival through different second messenger pathways. Dev Biol 168:235–246

    Article  PubMed  CAS  Google Scholar 

  • Smyth N, Vatansever HS, Murray P, Meyer M, Frie C, Paulsson M, Edgar D (1999) Absence of basement membranes after targeting the LAMC1 gene results in embryonic lethality due to failure of endoderm differentiation. J Cell Biol 144: 151–160

    Article  PubMed  CAS  Google Scholar 

  • Sunada Y, Campbell P (1996) Dystroglycan: a novel laminin receptor and its involvement in the pathogenesis of muscular dystrophy. In: Ekblom P, Timpl R (eds) The laminins. Harwood Academic Publishers, Amsterdam, pp 291–316

    Google Scholar 

  • Terranova VP, Rao CN, Kalebic T, Margulies IM, Liotta LA (1983) Laminin receptor on human breast carcinoma cells. Proc Natl Acad Sci USA 80: 444–448

    Article  PubMed  CAS  Google Scholar 

  • Tien L, Rayborn ME, Hollyfield JG (1992) Characterization of the interphotoreceptor matrix surrounding rod photoreceptors in the human retina. Exp Eye Res 55: 297–306

    Article  PubMed  CAS  Google Scholar 

  • Timpl R, Johansson S, van Delden V, Oberbaumer I, Hook M (1983) Characterization of protease-resistant fragments of laminin mediating attachment and spreading of rat hepatocytes. J Biol Chem 258: 8922–8927

    PubMed  CAS  Google Scholar 

  • Timpl R, Rohde H, Robey PG, Rennard SI, Foidart JM, Martin GR (1979) Laminin — a glycoprotein from basement membranes. J Biol Chem 254: 9933–9937

    PubMed  CAS  Google Scholar 

  • Tombran Tink J, Li A, Johnson MA, Johnson LV, Chader GJ (1992) Neurotrophic activity of interphotoreceptor matrix on human Y79 retinoblastoma cells. J Comp Neurol 317: 175–186

    Article  Google Scholar 

  • Tsukamoto Y, Taira E, Yamate J, Nakane Y, Kajimura K, Tsudzuki M, Kiso Y, Kotani T, Miki N, Sakuma S (1997) Gicerin, a cell adhesion molecule, participates in the histogenesis of retina. J Neurobiol 33: 769–780

    Article  PubMed  CAS  Google Scholar 

  • Turner DL, Cepko CL (1987) A common progenitor for neurons and glia persists in rat retina late in development. Nature 328: 131–136

    Article  PubMed  CAS  Google Scholar 

  • Turner DL, Snyder EY, Cepko CL (1990) Lineage-independent determination of cell type in the embryonic mouse retina. Neuron 4: 833–845

    Article  PubMed  CAS  Google Scholar 

  • Ueda H, Gohdo T, Ohno S (1998) Beta-dystroglycan localization in the photoreceptor and Müller cells in the rat retina revealed by immunoelectron microscopy. J Histochem Cytochem 46: 185–191

    Article  PubMed  CAS  Google Scholar 

  • Ueda H, Kato Y, Baba T, Terada N, Fujii Y, Tsukahara S, Ohno S (1997) Immunocytochemical study of dystrophin localization in cone cells of mouse retinas. Invest Ophthalmol Visual Sci 38: 1627–1630

    CAS  Google Scholar 

  • Ueda H, Kobayashi T, Mitsui K, Tsurugi K, Tsukahara S, Ohno S (1995) Dystrophin localization at presynapse in rat retina revealed by immunoelectron microscopy (see comments). Invest Ophthalmol Visual Sci 36:2318–2322

    CAS  Google Scholar 

  • Uteza Y, Rouillot JS, Kobetz A, Marchant D, Pecqueur S, Arnaud E, Prats H, Honiger J, Dufier JL, Abitbol M, Neuner-Jehle M (1999) Intravitreous transplantation of encapsulated fibroblasts secreting the human fibroblast growth factor 2 delays photoreceptor cell degeneration in Royal College of Surgeons rats. Proc Natl Acad Sci USA 96: 3126–3131

    Article  PubMed  CAS  Google Scholar 

  • Varner HH, Rayborn ME, Osterfeld AM, Hollyfield JG (1987) Localization of proteoglycan within the extracellular matrix sheath of cone photoreceptors. Exp Eye Res 44: 633–642

    Article  PubMed  CAS  Google Scholar 

  • Vidal F, Baudoin C, Miguel C, Galliano MF, Christiano AM, Uitto J, Ortonne JP, Meneguzzi G (1995) Cloning of the laminin alpha 3 chain gene (LAMA3) and identification of a homozygous deletion in a patient with Herlitz junctional epidermolysis bullosa. Genomics 30: 273–280

    Article  PubMed  CAS  Google Scholar 

  • Weidman TA, Kuwabara T (1969) Development of the rat retina. Invest Ophthalmol 8: 60–69

    PubMed  CAS  Google Scholar 

  • Weidman TA, Kuwabara T (1968) Postnatal development of the rat retina. An electron microscopic study. Arch Ophthalmol 79: 470–484

    Article  PubMed  CAS  Google Scholar 

  • Wetts R, Fraser SE (1988) Multipotent precursors can give rise to all major cell types of the frog retina. Science 239: 1142–1145

    Article  PubMed  CAS  Google Scholar 

  • Wetts R, Serbedzija GN, Fraser SE (1989) Cell lineage analysis reveals multipotent precursors in the ciliary margin of the frog retina. Dev Biol 136: 254–263

    Article  PubMed  CAS  Google Scholar 

  • Xu H, Christmas P, Wu XR, Wewer UM, Engvall E (1994) Defective muscle basement membrane and lack of M-laminin in the dystrophic dy/dy mouse. Proc Natl Acad Sci USA 91: 5572–5576

    Article  PubMed  CAS  Google Scholar 

  • Xu H, Wu XR, Wewer UM, Engvall E (1994) Murine muscular dystrophy caused by a mutation in the laminin alpha 2 (Lama2) gene. Nat Genet 8: 297–302

    Article  PubMed  CAS  Google Scholar 

  • Yao XY, Hageman GS, Marmor MF (1992) Recovery of retinal adhesion after enzymatic perturbation of the interphotoreceptor matrix. Invest Ophthalmol Visual Sci 33: 498–503

    CAS  Google Scholar 

  • Yao XY, Hageman GS, Marmor MF (1994) Retinal adhesiveness in the monkey. Invest Ophthalmol Visual Sci 35: 744–748

    CAS  Google Scholar 

  • Ying SY, Li S, Ishikawa M, Johnson LV (1995) Immunohistochemical localization of inhibin in the retinal interphotoreceptor matrix [letter]. Exp Eye Res 60: 585–590

    Article  PubMed  CAS  Google Scholar 

  • Yurchenco PD, Cheng YS, Colognato H (1992) Laminin forms an independent network in basement membranes. J Cell Biol 117: 1119–1133

    Article  PubMed  CAS  Google Scholar 

  • Zhao S, Barnstable CJ (1996) Differential effects of bFGF on development of the rat retina. Brain Res 723: 169–176

    Article  PubMed  CAS  Google Scholar 

  • Zrenner E, Stett A, Weiss S, Aramant RB, Guenther E, Kohler K, Miliczek KD, Seiler MJ, Haemmerle H (1999) Can subretinal microphotodiodes successfully replace degenerated photoreceptors? Vision Res 39: 2555–2567

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. MRC Institute of Hearing Research, Nottingham, UK

    Richard T. Libby

  2. Department of Biology, Boston College, Chestnut Hill, Massachusetts, USA

    William J. Brunken

  3. Cutaneous Biology Research Center, Massachussetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA

    William J. Brunken

  4. Departments of Neuroscience, Anatomy and Cell Biology, and Ophthalmology, Tufts University School of Medicine, Boston, Massachussetts, 02111, USA

    Dale D. Hunter

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  1. Richard T. Libby
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  2. William J. Brunken
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  3. Dale D. Hunter
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Editors and Affiliations

  1. Vision Research Laboratories, New England Eye Center, Tufts University School of Medicine, 750 Washington Street, Box 450, Boston, MA, 02111, USA

    M. Elizabeth Fini Ph. D.

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Libby, R.T., Brunken, W.J., Hunter, D.D. (2000). Roles of the Extracellular Matrix in Retinal Development and Maintenance. In: Fini, M.E. (eds) Vertebrate Eye Development. Results and Problems in Cell Differentiation, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-46826-4_7

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  • DOI: https://doi.org/10.1007/978-3-540-46826-4_7

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