Abstract
The mannose receptor acts as a molecular scavenger by mediating Ca2+-dependent recognition and internalization of glycoconjugates terminating in mannose, N-acetylglucosamine or fucose. The receptor was identified when it was found that glycoproteins terminating in GlcNAc or mannose, including lysosomal enzymes, are rapidly cleared from the bloodstream by the liver (Schlesinger et al. 1976). The mannose receptor was found to be located on hepatic endothelial cells and Kupffer cells but not on hepatocytes (Schlesinger et al. 1978). The receptor has since been found on most types of tissue macrophages, including those of the placenta, but not on circulating monocytes (Shepherd et al. 1982). The retinal pigmented epithelium, a phagocytic cell layer, also expresses the mannose receptor (Shepherd et al. 1991). More recently, the mannose receptor has been identified on CD1-positive dendritic cells and Langerhan’s cells (Sallusto et al. 1995; Condaminet et al. 1998).
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References
Banyai L, Patthy L (1991) Evidence for the involvement of type II domains in collagen binding by 72-kDa type IV procollagenase. FEBS Lett 282: 23–25
Biessen EAL, Noorman F, van Teijlingen ME, Kuiper J, Barret-Bergshoeff M, Rijken DC, van Berkel TJC (1996) Lysine-based cluster mannosides that inhibit ligand binding to the human mannose receptor at nanomolar concentration. J Biol Chem 271: 28024–28030
Biessen EAL, van Teijlingen M, Vietsch H, Barret-Bergshoeff MM, Bijsterbosch MK, Rijken DC, van Berkel TIC, Kuiper J (1997) Antagonists of the mannose receptor and the LDL-receptorrelated protein dramatically delay the clearance of tissue-type plasminogen activator. Circulation 95: 46–52
Chakraborty P, Das PK (1988) Role of mannose/GIcNAc receptors in blood clearance and cellular attachment of Leishmania donovani. Mol Biochem Parasitol 28: 55–62
Chen WI, Goldstein JL, Brown MS (1990) NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor. J Biol Chem 265: 3116–3123
Condaminet B, Peguet-Navarro J, Stahl PD, Dalbiez-Gauthier C, Schmitt D, Berthier-Vergnes O (1998) Human epidermal Langerhans cells express the mannose-fucose binding receptor. Eur J Immunol 28: 3541–3551
Cool DE, Edgell CJ, Louie GV, Zoller MJ, Brayer GD, MacGillivray RT (1985) Characterization of human blood coagulation factor XII cDNA. Prediction of the primary structure of factor XII and the tertiary structure of beta-factor XIIa. J Biol Chem 260: 13666–13676
Drickamer K (1993) Increasing diversity of animal lectin structures. Curr Opin Struct Biol 3: 393–400
Drickamer K, Taylor ME (1993) Biology of animal lectins. Annu Rev Cell Biol 9:237–264
Engering AJ, Cella M, Fluisma D, Brockhaus M, Hoefsmit ECM, Lanzavecchia A, Pieters J (1997) The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cells. Eur J Immunol 27:2417–2425
Ezekowitz RAB, Sastry K, Bailly P, Warner A (1990) Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells. J Exp Med 172: 1785–1794
Ezekowitz RAB, Williams DJ, Koziel H, Armstrong MYK, Warner A, Richards FF, Rose RM (1991) Uptake of Pneumocystis carinii mediated by the macrophage mannose receptor. Nature 351: 155–158
Fiete D, Beranek MC, Baenziger JU (1997) The macrophage/endothelial cell mannose receptor cDNA encodes a protein that binds oligosaccharides terminating with SO4–4-GalNAc 31, 4G1cNAc(3 or Man at independent sites. Proc Natl Acad Sci USA 94: 11256–11261
Fiete D, Beranek MC, Baenziger JU (1998) A cysteine-rich domain of the “mannose” receptor mediates Ga1NAc-4-SO4 binding. Proc Natl Acad Sci USA 95: 2089–2093
Graves BJ, Crowther RL, Chandran C, Rumberger JM, Li-S, Huang KS, Presky-DH, Familletti PC, Wolitzky BA, Burns DK (1994) Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains. Nature 367: 532–538
Haltiwanger RS, Hill RL (1986) Isolation of a rat alveolar macrophage lectin. J Biol Chem 261: 7440–7444
Hitchen PG, Mullin NP, Taylor ME (1998) Orientation of sugars bound to the principal C-type carbohydrate-recognition domain of the macrophage mannose receptor. Biochem J 333: 601–608
Iobst ST, Wormald MR, Weis WI, Dwek RA, Drickamer K (1994) Binding of sugar ligands to Ca (2+)-dependent animal lectins. I. Analysis of mannose binding by site-directed mutagenesis and NMR. J Biol Chem 269: 15505–15511
Ishizaki J, Hanasaki K, Higashino K, Kishino J, Kikuchi N, Ohara O, Arita H (1994) Molecular cloning of pancreatic group I phospholipase A2 receptor. J Biol Chem 269: 5897–5904
Jiang W, Swiggard WJ, Heufler C, Peng M, Mirza A, Steinman RM, Nussenzweig MC (1995) The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature 375: 151–155
Kornblihtt AR, Umezawa K, Vibe-Pedersen K, Baralle FE (1985) Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene. EMBO J 4: 1755–1759
Kruskal A, Sastry K, Warner A, Mathieu CE, Ezekowitz RAB (1992) Phagocytic chimeric receptors require both transmembrane and cytoplasmic domains from the mannose receptor. J Exp Med 176: 1673–1680
Lambeau G, Ancian P, Barhanin J, Lazdunski M (1994) Cloning and expression of a membrane receptor for secretory phospholipases A2. J Biol Chem 269: 1575–1578
Lambeau G, Ancian P, Mattei M-G, Lazdunski M (1995) The human 180-kDa receptor for secretory phospholipases A2. J Biol Chem 270: 8963–8970
Lennartz MR, Cole FS, Shepherd VL, Wileman TE, Stahl PD (1987) Isolation and characterization of a mannose-specific endocytosis receptor from human placenta. J Biol Chem 262: 9943–9944
Lennartz MR, Cole FS, Stahl PD (1989) Biosynthesis and processing of the mannose receptor in human macrophages. J Biol Chem 264: 2385–2390
Lobel P, Dahms NM, Kornfeld S (1988) Cloning and sequence analysis of the cation-independent mannose 6-phosphate receptor. J Biol Chem 263: 2563–2570
Mullin NP, Hall KT, Taylor ME (1994) Characterization of ligand binding to a carbohydrate-recognition domain of the macrophage mannose receptor. J Biol Chem 269: 28405–28413
Mullin NP, Hitchen PG, Taylor ME (1997) Mechanism of Ca’- and monosaccharide-binding to a C-type carbohydrate-recognition domain of the macrophage mannose receptor. J Biol Chem 272: 5668–5681
Ng K K-S, Drickamer K, Weis WI (1996) Structural analysis of monosaccharide recognition by rat liver mannose-binding protein. J Biol Chem 271: 663–674
Nicolas J-P, Lambeau G, Lazdunski M (1995) Identification of the binding domain for secretory phospholipases A2 on their M-type 180-kDa membrane receptor. J Biol Chem 270: 28869–28873
Otter M, Barrett-Bergshoeff MM, Rijken DC (1991) Binding of tissue-type plasminogen activator by the mannose receptor. J Biol Chem 266: 13931–13935
Otter M, Zockova P, Kuiper J, van-Berkel TJ, Barrett-Bergshoeff MM, Rijken DC (1992) Isolation and characterization of the mannose receptor from human liver potentially involved in the plasma clearance of tissue-type plasminogen activator. Hepatology 16: 54–59
Prigozy TI, Sieling PA, Clemens D, Stewart PL, Behar SM, Porcelli SA, Brenner MB, Modlin RL, Kronnenberg M (1997) The mannose receptor delivers lipoglycan antigens to endosomes for presentation to T cells by CD1b molecules. Immunity 6: 187–197
Sallusto F, Cella M, Danieli C, Lanzavecchia A (1995) Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J Exp Med 182: 389–400
Schlesinger LS (1993) Macrophage phagocytosis of virulent but not attenuated strains of Mycobacterium tuberculosis is mediated by mannose receptors in addition to complement receptors. J Immunol 150: 2920–2930
Schlesinger P, Rodman JS, Frey M, Lang S, Stahl P (1976) Clearance of lysosomal hydrolases following intravenous infusion. The role of the liver in the clearance of ß-glucuronidase and N-acetyl-(3-D-glucosaminidase. Arch Biochem Biophys 177: 606–614
Schlesinger P, Doebber TW, Mandell BF, White R, DeSchryver C, Rodman JS, Miller MJ, Stahl P (1978) Plasma clearance of glycoproteins with terminal mannose and G1cNAc by liver non-parenchymal cells. Biochem J 176: 103–109
Shepherd VL, Hoidal JR (1990) Clearance of neutrophil-derived myeloperoxidase by the macrophage mannose receptor. Am J Respir Cell Mol Biol 2: 335–340
Shepherd VL, Cambell TJ, Senior RM, Stahl PD (1982) Characterization of the mannose/fucose receptor on human mononuclear phagocytes. J Retic Endothel Soc 32: 423–421
Shepherd VL, Tarnowski BI, McLaughlin BJ (1991) Isolation and characterization of a mannose receptor from human pigment epithelium. Invest Opthalmol Vis Sci 32: 1779–17784
Smedsrod B, Melkko J, Risteli L, Risteli J (1990) Circulating C-terminal propeptide of type I collagen is cleared mainly via the mannose receptor in liver endothelial cells. Biochem J 271: 345–350
Stahl PD, Schlesinger PH (1980) Receptor mediated-pinocytosis of mannose/G1cNAc-terminated glycoproteins and lysosomal enzymes by macrophages. Trends Biochem Sci 5: 194–196
Tan MCAA, Momaas AM, Drihout JW, Jordens R, Onderwater JJM, Verwoerd D, Mulder AA, van der Heiden AN, Scheidegger D, Oomen LCJM, Ottenhoff THM, Tulp A, Neefjes JJ, Koning F (1997) Mannose receptor-mediated uptake of antigens strongly enhances HLA class II-restricted antigen presentation by cultured dendritic cells. Eur J Immunol 27: 2426–2435
Taylor ME (1997) Evolution of a family of receptors containing multiple C-type carbohydrate-recognition domains. Glycobiology 7: R5 - R8
Taylor ME, Drickamer K (1993) Structural requirements for high affinity binding of complex ligands by the macrophage mannose receptor. J Biol Chem 268: 399–404
Taylor ME, Conary JT, Lennarz MR, Stahl PD, Drickamer K (1990) Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains. J Biol Chem 265: 12156–12162
Taylor ME, Bezouska K, Drickamer K (1992) Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor. J Biol Chem 267: 1719–1726
Weis WI, Drickamer K (1996) Structural basis of lectin-carbohydrate-recognition. Annu Rev Biochem 65: 441–473
Weis WI, Taylor ME, Drickamer K (1998) The C-type lectin superfamily in the immune system. Immunol Rev 163: 19–34
Weis WI, Drickamer K, Hendrickson WA (1992) Structure of a C-type mannose-binding protein complexed with an oligosaccharide. Nature 360: 127–134
Wileman T, Boshans R, Stahl PD (1984) Uptake and transport of mannosylated ligands by alveolar macrophages. Studies on ATP-dependent receptor ligand dissociation. J Biol Chem 260: 7387–7393
Wu K, Yuan J, Lasky LA (1996) Characterization of a novel member of the macrophage mannose receptor type C lectin family. J Biol Chem 271: 21323–21330
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Taylor, M.E. (2001). Structure and Function of the Macrophage Mannose Receptor. In: Crocker, P.R. (eds) Mammalian Carbohydrate Recognition Systems. Results and Problems in Cell Differentiation, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-46410-5_6
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DOI: https://doi.org/10.1007/978-3-540-46410-5_6
Publisher Name: Springer, Berlin, Heidelberg
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